Reduction of gray matter density in the extrastriate body area in women with anorexia nervosa
Body processing has been associated functionally to the so called extrastriate body area (EBA) which is located in the lateral occipital cortex. As body image disturbance is one of the main diagnostic criteria in anorexia nervosa (AN) this study aimed at looking for alterations in gray matter densit...
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| Veröffentlicht in: | Behavioural brain research 2010-01, Vol.206 (1), p.63-67 |
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| creator | Suchan, Boris Busch, Martin Schulte, Dietmar Grönermeyer, Dietrich Herpertz, Stephan Vocks, Silja |
| description | Body processing has been associated functionally to the so called extrastriate body area (EBA) which is located in the lateral occipital cortex. As body image disturbance is one of the main diagnostic criteria in anorexia nervosa (AN) this study aimed at looking for alterations in gray matter density in women with (AN) especially in the EBA. High resolution T1 images from 15 women with AN and 15 age matched healthy controls women were contrasted using voxel based morphometry (VBM). Additionally functional localizer scans were used to determine functionally the EBA of each participant. In general, total gray matter volumes did differ between groups. VBM results yielded evidence for a reduction of gray matter density in the left EBA. This reduction, which resulted from whole brain analysis, was localised within the activation cluster of the EBA localizer scan. The current results provide for the first time evidence for structural alterations in the EBA in patients with AN which might suggest that body image distortion is related at least in part to structural alteration in the EBA. |
| doi_str_mv | 10.1016/j.bbr.2009.08.035 |
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As body image disturbance is one of the main diagnostic criteria in anorexia nervosa (AN) this study aimed at looking for alterations in gray matter density in women with (AN) especially in the EBA. High resolution T1 images from 15 women with AN and 15 age matched healthy controls women were contrasted using voxel based morphometry (VBM). Additionally functional localizer scans were used to determine functionally the EBA of each participant. In general, total gray matter volumes did differ between groups. VBM results yielded evidence for a reduction of gray matter density in the left EBA. This reduction, which resulted from whole brain analysis, was localised within the activation cluster of the EBA localizer scan. The current results provide for the first time evidence for structural alterations in the EBA in patients with AN which might suggest that body image distortion is related at least in part to structural alteration in the EBA.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2009.08.035</identifier><identifier>PMID: 19729041</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Anorexia nervosa ; Anorexia Nervosa - pathology ; Anorexia Nervosa - physiopathology ; Behavioral psychophysiology ; Biological and medical sciences ; Brain Mapping ; Eating behavior disorders ; Extrastriate body area (EBA) ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Medical sciences ; Neuropsychological Tests ; Occipital Lobe - pathology ; Occipital Lobe - physiopathology ; Organ Size ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. 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As body image disturbance is one of the main diagnostic criteria in anorexia nervosa (AN) this study aimed at looking for alterations in gray matter density in women with (AN) especially in the EBA. High resolution T1 images from 15 women with AN and 15 age matched healthy controls women were contrasted using voxel based morphometry (VBM). Additionally functional localizer scans were used to determine functionally the EBA of each participant. In general, total gray matter volumes did differ between groups. VBM results yielded evidence for a reduction of gray matter density in the left EBA. This reduction, which resulted from whole brain analysis, was localised within the activation cluster of the EBA localizer scan. The current results provide for the first time evidence for structural alterations in the EBA in patients with AN which might suggest that body image distortion is related at least in part to structural alteration in the EBA.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - pathology</subject><subject>Anorexia Nervosa - physiopathology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Eating behavior disorders</subject><subject>Extrastriate body area (EBA)</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Neuropsychological Tests</subject><subject>Occipital Lobe - pathology</subject><subject>Occipital Lobe - physiopathology</subject><subject>Organ Size</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Voxel based morphometry (VBM)</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtuFDEQRS0EIpPAB7BB3gCrbqq67X6IFYogRIqEFMESWX5UE4-m28H2hMzfx8OMyC6bqkWde1U6jL1BqBGw-7iujYl1AzDWMNTQymdshUPfVL0U43O2KkxXibYZTthpSmsAECDxJTvBsW9GELhiv67JbW32YeFh4r-j3vFZ50yRO1qSzzvuF55viNN9jjrl6HUmboLbcR1J769_w0xl-nzD9RIi3XvNF4p3IelX7MWkN4leH_cZ-_n1y4_zb9XV94vL889XlRXY5mpsnezQCWvB6L63VhgjsTV6HHucQAOaXkrbUGscElgnwIqpxZFQiq6Z2jP24dB7G8OfLaWsZp8sbTZ6obBNqm8FFj0wFPL9k2SDKGTfiQLiAbQxpBRpUrfRzzruFILa21drVeyrvX0Fgyr1JfP2WL41M7nHxFF3Ad4dAZ2s3kxRL9an_1zTiE7Cvy8_HTgq0u48RZWsp8WS85FsVi74J954AGJ0ooU</recordid><startdate>20100105</startdate><enddate>20100105</enddate><creator>Suchan, Boris</creator><creator>Busch, Martin</creator><creator>Schulte, Dietmar</creator><creator>Grönermeyer, Dietrich</creator><creator>Herpertz, Stephan</creator><creator>Vocks, Silja</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20100105</creationdate><title>Reduction of gray matter density in the extrastriate body area in women with anorexia nervosa</title><author>Suchan, Boris ; Busch, Martin ; Schulte, Dietmar ; Grönermeyer, Dietrich ; Herpertz, Stephan ; Vocks, Silja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-93d561d4cc0ba77cc4bb513ba9971f0a01b755c2e3bd1e0cd40c4f319e15462f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Anorexia nervosa</topic><topic>Anorexia Nervosa - pathology</topic><topic>Anorexia Nervosa - physiopathology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Eating behavior disorders</topic><topic>Extrastriate body area (EBA)</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Neuropsychological Tests</topic><topic>Occipital Lobe - pathology</topic><topic>Occipital Lobe - physiopathology</topic><topic>Organ Size</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Voxel based morphometry (VBM)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suchan, Boris</creatorcontrib><creatorcontrib>Busch, Martin</creatorcontrib><creatorcontrib>Schulte, Dietmar</creatorcontrib><creatorcontrib>Grönermeyer, Dietrich</creatorcontrib><creatorcontrib>Herpertz, Stephan</creatorcontrib><creatorcontrib>Vocks, Silja</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suchan, Boris</au><au>Busch, Martin</au><au>Schulte, Dietmar</au><au>Grönermeyer, Dietrich</au><au>Herpertz, Stephan</au><au>Vocks, Silja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of gray matter density in the extrastriate body area in women with anorexia nervosa</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2010-01-05</date><risdate>2010</risdate><volume>206</volume><issue>1</issue><spage>63</spage><epage>67</epage><pages>63-67</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Body processing has been associated functionally to the so called extrastriate body area (EBA) which is located in the lateral occipital cortex. As body image disturbance is one of the main diagnostic criteria in anorexia nervosa (AN) this study aimed at looking for alterations in gray matter density in women with (AN) especially in the EBA. High resolution T1 images from 15 women with AN and 15 age matched healthy controls women were contrasted using voxel based morphometry (VBM). Additionally functional localizer scans were used to determine functionally the EBA of each participant. In general, total gray matter volumes did differ between groups. VBM results yielded evidence for a reduction of gray matter density in the left EBA. This reduction, which resulted from whole brain analysis, was localised within the activation cluster of the EBA localizer scan. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adult and adolescent clinical studies Analysis of Variance Anorexia nervosa Anorexia Nervosa - pathology Anorexia Nervosa - physiopathology Behavioral psychophysiology Biological and medical sciences Brain Mapping Eating behavior disorders Extrastriate body area (EBA) Female Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Medical sciences Neuropsychological Tests Occipital Lobe - pathology Occipital Lobe - physiopathology Organ Size Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Voxel based morphometry (VBM) |
| title | Reduction of gray matter density in the extrastriate body area in women with anorexia nervosa |
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