Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde

The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reac...

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Veröffentlicht in:	BioEssays 2009-11, Vol.31 (11), p.1161-1171
Hauptverfasser:	Belogurov, Alexey Jr, Kozyr, Arina, Ponomarenko, Natalia, Gabibov, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	abzymes Alzheimer Disease - immunology Animals anti-DNA antibodies Antibodies, Catalytic - chemistry Antibodies, Catalytic - physiology Autoimmunity Biochemistry - methods catalytic vaccines Diabetes Mellitus - immunology Factor VIII - physiology Humans Immunoglobulins - chemistry Models, Biological Multiple Sclerosis - immunology Protein Engineering - methods Sepsis - immunology Thyroiditis - immunology transition state Vaccines
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