Liquid chromatography/positive ion electrospray tandem mass spectrometry method for the quantification of hydrochloride meptazinol in human plasma: Application to a pharmacokinetic study

A robust and validated liquid chromatography–tandem mass spectrometry (LC–MS/MS) method with positive electrospray ionization (ESI) was developed for the determination of hydrochloride meptazinol in human plasma. After liquid–liquid extraction of 200 μl of human plasma, HPLC separation was achieved...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2009-11, Vol.877 (30), p.3787-3791
Hauptverfasser:	Qiao, Jian, Tan, Zhirong, Li, Weiyong, Huang, Lu, Ge, Miaomiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - urine Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, Liquid - methods Female Fundamental and applied biological sciences. Psychology General pharmacology Humans Hydrochloride meptazinol LC–MS/MS Male Medical sciences Meptazinol - blood Meptazinol - pharmacokinetics Meptazinol - urine Pharmacokinetic Pharmacology. Drug treatments Spectrometry, Mass, Electrospray Ionization - methods
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