Green tea polyphenols ameliorate pancreatic injury in cerulein-induced murine acute pancreatitis

Green tea polyphenols (GTPs) are naturally occurring antioxidants acting through pathways that include reactive oxygen species and nuclear factor kappa B (NF-kappaB). This study investigates the effect of GTPs in a cerulein-induced murine model of acute pancreatitis (AP). Male CD mice (median weight...

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Veröffentlicht in:	Pancreas 2009-11, Vol.38 (8), p.954-967
Hauptverfasser:	Babu, Benoy I, Malleo, Giuseppe, Genovese, Tiziana, Mazzon, Emanuela, Di Paola, Rosanna, Crisafulli, Concetta, Caminiti, Rocco, Siriwardena, Ajith K, Cuzzocrea, Salvatore
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Apoptosis - drug effects Blotting, Western Ceruletide I-kappa B Proteins - metabolism Immunohistochemistry In Situ Nick-End Labeling Injections, Intraperitoneal Intercellular Adhesion Molecule-1 - metabolism Lipid Peroxidation - drug effects Male Mice Neutrophil Infiltration - drug effects NF-kappa B - metabolism P-Selectin - metabolism Pancreas - drug effects Pancreas - metabolism Pancreas - pathology Pancreatitis - chemically induced Pancreatitis - prevention & control Phenol - administration & dosage Phenol - pharmacology Poly(ADP-ribose) Polymerases - metabolism Tea - chemistry Time Factors Transforming Growth Factor beta - metabolism Tumor Necrosis Factor-alpha - metabolism Vascular Endothelial Growth Factor A - metabolism
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