Legume intake and the risk of cancer: a multisite case-control study in Uruguay
Background Previous studies have suggested that a high intake of legumes may decrease the risk of stomach and prostate cancer and some other cancers. However, the evidence is still limited. To further explore the association between legume intake and cancer risk we conducted a case-control study of...
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| Veröffentlicht in: | Cancer causes & control 2009-11, Vol.20 (9), p.1605-1615 |
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| description | Background Previous studies have suggested that a high intake of legumes may decrease the risk of stomach and prostate cancer and some other cancers. However, the evidence is still limited. To further explore the association between legume intake and cancer risk we conducted a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. Results The highest versus the lowest tertile of legume intake was associated with a significant decrease in the risk of cancers of the oral cavity and pharynx (OR = 0.48, 95% CI: 0.34-0.68), esophagus (OR = 0.54, 95% CI: 0.38-0.77), larynx (OR = 0.55, 95% CI: 0.40-0.77), upper aerodigestive tract (OR = 0.50, 95% CI: 0.40-0.63), stomach (OR = 0.69, 95% CI: 0.49-0.97), colorectum (OR = 0.43, 95% CI: 0.32-0.59), kidney (OR = 0.41, 95% CI: 0.24-0.71), and all sites combined (OR = 0.68, 95% CI: 0.59-0.78). No significant association was observed between legume intake and cancers of the lung (OR = 1.03, 95% CI: 0.83-1.27), breast (OR = 0.89, 95% CI: 0.65-1.20), prostate (OR = 0.87, 95% CI: 0.64-1.18) or bladder (OR = 0.82, 95% CI: 0.57-1.17). Similar results were found for both beans and lentils. Conclusion Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder. Further investigations of these associations in prospective cohort studies are warranted. |
| doi_str_mv | 10.1007/s10552-009-9406-z |
| format | Article |
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However, the evidence is still limited. To further explore the association between legume intake and cancer risk we conducted a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. Results The highest versus the lowest tertile of legume intake was associated with a significant decrease in the risk of cancers of the oral cavity and pharynx (OR = 0.48, 95% CI: 0.34-0.68), esophagus (OR = 0.54, 95% CI: 0.38-0.77), larynx (OR = 0.55, 95% CI: 0.40-0.77), upper aerodigestive tract (OR = 0.50, 95% CI: 0.40-0.63), stomach (OR = 0.69, 95% CI: 0.49-0.97), colorectum (OR = 0.43, 95% CI: 0.32-0.59), kidney (OR = 0.41, 95% CI: 0.24-0.71), and all sites combined (OR = 0.68, 95% CI: 0.59-0.78). No significant association was observed between legume intake and cancers of the lung (OR = 1.03, 95% CI: 0.83-1.27), breast (OR = 0.89, 95% CI: 0.65-1.20), prostate (OR = 0.87, 95% CI: 0.64-1.18) or bladder (OR = 0.82, 95% CI: 0.57-1.17). Similar results were found for both beans and lentils. Conclusion Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder. Further investigations of these associations in prospective cohort studies are warranted.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-009-9406-z</identifier><identifier>PMID: 19653110</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Beans ; Biomedical and Life Sciences ; Biomedicine ; Bladder ; Cancer Research ; Case control studies ; Cigarette smoking ; Cohort studies ; Diet ; Digestive System Neoplasms - epidemiology ; Epidemiology ; Esophagus ; Fabaceae ; Female ; Fruits ; Hematology ; Humans ; Interviews ; Larynx ; Legumes ; Lentils ; Male ; Medical research ; Middle Aged ; Neoplasms - epidemiology ; Nutrition research ; Oncology ; Original Paper ; Prostate cancer ; Public Health ; Questionnaires ; Response rates ; Risk Factors ; Smoking cessation ; Stomach ; Surveys and Questionnaires ; Vegetables</subject><ispartof>Cancer causes & control, 2009-11, Vol.20 (9), p.1605-1615</ispartof><rights>Copyright 2009 Springer</rights><rights>Springer Science+Business Media B.V. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-758143dbb041b9793371ca7e398a583a22484de9c1f43eca5f25359b4824ec1e3</citedby><cites>FETCH-LOGICAL-c447t-758143dbb041b9793371ca7e398a583a22484de9c1f43eca5f25359b4824ec1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25621270$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25621270$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27929,27930,41493,42562,51324,58022,58255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19653110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>De Stefani, Eduardo</creatorcontrib><creatorcontrib>Ronco, Alvaro</creatorcontrib><creatorcontrib>Boffetta, Paolo</creatorcontrib><creatorcontrib>Deneo-Pellegrini, Hugo</creatorcontrib><creatorcontrib>Acosta, Giselle</creatorcontrib><creatorcontrib>Mendilaharsu, Maria</creatorcontrib><title>Legume intake and the risk of cancer: a multisite case-control study in Uruguay</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description>Background Previous studies have suggested that a high intake of legumes may decrease the risk of stomach and prostate cancer and some other cancers. However, the evidence is still limited. To further explore the association between legume intake and cancer risk we conducted a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. Results The highest versus the lowest tertile of legume intake was associated with a significant decrease in the risk of cancers of the oral cavity and pharynx (OR = 0.48, 95% CI: 0.34-0.68), esophagus (OR = 0.54, 95% CI: 0.38-0.77), larynx (OR = 0.55, 95% CI: 0.40-0.77), upper aerodigestive tract (OR = 0.50, 95% CI: 0.40-0.63), stomach (OR = 0.69, 95% CI: 0.49-0.97), colorectum (OR = 0.43, 95% CI: 0.32-0.59), kidney (OR = 0.41, 95% CI: 0.24-0.71), and all sites combined (OR = 0.68, 95% CI: 0.59-0.78). No significant association was observed between legume intake and cancers of the lung (OR = 1.03, 95% CI: 0.83-1.27), breast (OR = 0.89, 95% CI: 0.65-1.20), prostate (OR = 0.87, 95% CI: 0.64-1.18) or bladder (OR = 0.82, 95% CI: 0.57-1.17). Similar results were found for both beans and lentils. Conclusion Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder. Further investigations of these associations in prospective cohort studies are warranted.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Beans</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bladder</subject><subject>Cancer Research</subject><subject>Case control studies</subject><subject>Cigarette smoking</subject><subject>Cohort studies</subject><subject>Diet</subject><subject>Digestive System Neoplasms - epidemiology</subject><subject>Epidemiology</subject><subject>Esophagus</subject><subject>Fabaceae</subject><subject>Female</subject><subject>Fruits</subject><subject>Hematology</subject><subject>Humans</subject><subject>Interviews</subject><subject>Larynx</subject><subject>Legumes</subject><subject>Lentils</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Neoplasms - epidemiology</subject><subject>Nutrition research</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Prostate cancer</subject><subject>Public Health</subject><subject>Questionnaires</subject><subject>Response rates</subject><subject>Risk Factors</subject><subject>Smoking cessation</subject><subject>Stomach</subject><subject>Surveys and Questionnaires</subject><subject>Vegetables</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtv1DAURi0EokPhB7AALBawMvgZx-xQxUsaqQuYteU4N0OmSVz8WEx_PR5lRCUWXVnyPd9nXR-EXjL6gVGqPyZGleKEUkOMpA25e4Q2TGlBNOfqMdpQozRRXIoL9CylA6VUNZw-RRfMNEowRjfoegv7MgMel-xuALulx_k34DimGxwG7N3iIX7CDs9lymMaM9S7BMSHJccw4ZRLf6xpvItlX9zxOXoyuCnBi_N5iXZfv_y6-k62199-XH3eEi-lzkSrlknRdx2VrDPaCKGZdxqEaZ1qheNctrIH49kgBXinBq6EMp1suQTPQFyi92vvbQx_CqRs5zF5mCa3QCjJaiHrFzVaVvLdgyRnQnLWiAq-_Q88hBKXusWJoZorbirEVsjHkFKEwd7GcXbxaBm1Jyl2lWKrFHuSYu9q5vW5uHQz9PeJs4UK8BVIdbTsId6__FDrqzV0SDnEf6W8KmZcn0rfrPPBBev21ajd_eS0bsIaYwxtxF-9UKhI</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Aune, Dagfinn</creator><creator>De Stefani, Eduardo</creator><creator>Ronco, Alvaro</creator><creator>Boffetta, Paolo</creator><creator>Deneo-Pellegrini, Hugo</creator><creator>Acosta, Giselle</creator><creator>Mendilaharsu, Maria</creator><general>Dordrecht : Springer Netherlands</general><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Legume intake and the risk of cancer: a multisite case-control study in Uruguay</title><author>Aune, Dagfinn ; De Stefani, Eduardo ; Ronco, Alvaro ; Boffetta, Paolo ; Deneo-Pellegrini, Hugo ; Acosta, Giselle ; Mendilaharsu, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-758143dbb041b9793371ca7e398a583a22484de9c1f43eca5f25359b4824ec1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Beans</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bladder</topic><topic>Cancer Research</topic><topic>Case control studies</topic><topic>Cigarette smoking</topic><topic>Cohort studies</topic><topic>Diet</topic><topic>Digestive System Neoplasms - epidemiology</topic><topic>Epidemiology</topic><topic>Esophagus</topic><topic>Fabaceae</topic><topic>Female</topic><topic>Fruits</topic><topic>Hematology</topic><topic>Humans</topic><topic>Interviews</topic><topic>Larynx</topic><topic>Legumes</topic><topic>Lentils</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Neoplasms - epidemiology</topic><topic>Nutrition research</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Prostate cancer</topic><topic>Public Health</topic><topic>Questionnaires</topic><topic>Response rates</topic><topic>Risk Factors</topic><topic>Smoking cessation</topic><topic>Stomach</topic><topic>Surveys and Questionnaires</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>De Stefani, Eduardo</creatorcontrib><creatorcontrib>Ronco, Alvaro</creatorcontrib><creatorcontrib>Boffetta, Paolo</creatorcontrib><creatorcontrib>Deneo-Pellegrini, Hugo</creatorcontrib><creatorcontrib>Acosta, Giselle</creatorcontrib><creatorcontrib>Mendilaharsu, Maria</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aune, Dagfinn</au><au>De Stefani, Eduardo</au><au>Ronco, Alvaro</au><au>Boffetta, Paolo</au><au>Deneo-Pellegrini, Hugo</au><au>Acosta, Giselle</au><au>Mendilaharsu, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Legume intake and the risk of cancer: a multisite case-control study in Uruguay</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>20</volume><issue>9</issue><spage>1605</spage><epage>1615</epage><pages>1605-1615</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Background Previous studies have suggested that a high intake of legumes may decrease the risk of stomach and prostate cancer and some other cancers. However, the evidence is still limited. To further explore the association between legume intake and cancer risk we conducted a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. Results The highest versus the lowest tertile of legume intake was associated with a significant decrease in the risk of cancers of the oral cavity and pharynx (OR = 0.48, 95% CI: 0.34-0.68), esophagus (OR = 0.54, 95% CI: 0.38-0.77), larynx (OR = 0.55, 95% CI: 0.40-0.77), upper aerodigestive tract (OR = 0.50, 95% CI: 0.40-0.63), stomach (OR = 0.69, 95% CI: 0.49-0.97), colorectum (OR = 0.43, 95% CI: 0.32-0.59), kidney (OR = 0.41, 95% CI: 0.24-0.71), and all sites combined (OR = 0.68, 95% CI: 0.59-0.78). No significant association was observed between legume intake and cancers of the lung (OR = 1.03, 95% CI: 0.83-1.27), breast (OR = 0.89, 95% CI: 0.65-1.20), prostate (OR = 0.87, 95% CI: 0.64-1.18) or bladder (OR = 0.82, 95% CI: 0.57-1.17). Similar results were found for both beans and lentils. Conclusion Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder. Further investigations of these associations in prospective cohort studies are warranted.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>19653110</pmid><doi>10.1007/s10552-009-9406-z</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Beans Biomedical and Life Sciences Biomedicine Bladder Cancer Research Case control studies Cigarette smoking Cohort studies Diet Digestive System Neoplasms - epidemiology Epidemiology Esophagus Fabaceae Female Fruits Hematology Humans Interviews Larynx Legumes Lentils Male Medical research Middle Aged Neoplasms - epidemiology Nutrition research Oncology Original Paper Prostate cancer Public Health Questionnaires Response rates Risk Factors Smoking cessation Stomach Surveys and Questionnaires Vegetables |
| title | Legume intake and the risk of cancer: a multisite case-control study in Uruguay |
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