Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosis
We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph n...
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| Veröffentlicht in: | International journal of clinical oncology 2009-10, Vol.14 (5), p.468-472 |
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| creator | Yamada, Tadaaki Ohtsubo, Koushiro Mouri, Hisatsugu Yamashita, Kaname Yasumoto, Kazuo Izumi, Kouji Zen, Yoh Watanabe, Hiroyuki Yano, Seiji |
| description | We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and hormonal therapy had been administered. Following an increase in the level of pro-gastrin-releasing peptide (ProGRP), combined chemotherapy with cisplatin plus etoposide was implemented and showed efficacy in targeting the small cell carcinoma. In March 2008, he presented with signs of meningeal irritation; his condition deteriorated quickly and multiple brain metastases were confirmed by magnetic resonance imaging (MRI). A sample of cerebrospinal fluid collected by lumbar puncture showed cancer cells and an elevated level of ProGRP. Small cell carcinoma of the prostate complicated with meningeal carcinomatosis was diagnosed. A different chemotherapy regimen was then administered, consisting of a combination of carboplatin plus irinotecan, which is one of the most common first-line treatments for extensive-stage small cell lung carcinoma. From day 20 after the initiation of this therapy, he gradually recovered from the signs of meningeal irritation, and brain MRI showed nearly normal findings; also, the serum level of ProGRP was reduced. In conclusion, we report the efficacy of combined treatment with carboplatin plus irinotecan for small cell carcinoma of the prostate complicated with meningeal carcinomatosis. Because this clinical condition is extremely rare, a gold standard treatment has yet to be established. |
| doi_str_mv | 10.1007/s10147-008-0869-9 |
| format | Article |
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In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and hormonal therapy had been administered. Following an increase in the level of pro-gastrin-releasing peptide (ProGRP), combined chemotherapy with cisplatin plus etoposide was implemented and showed efficacy in targeting the small cell carcinoma. In March 2008, he presented with signs of meningeal irritation; his condition deteriorated quickly and multiple brain metastases were confirmed by magnetic resonance imaging (MRI). A sample of cerebrospinal fluid collected by lumbar puncture showed cancer cells and an elevated level of ProGRP. Small cell carcinoma of the prostate complicated with meningeal carcinomatosis was diagnosed. A different chemotherapy regimen was then administered, consisting of a combination of carboplatin plus irinotecan, which is one of the most common first-line treatments for extensive-stage small cell lung carcinoma. From day 20 after the initiation of this therapy, he gradually recovered from the signs of meningeal irritation, and brain MRI showed nearly normal findings; also, the serum level of ProGRP was reduced. In conclusion, we report the efficacy of combined treatment with carboplatin plus irinotecan for small cell carcinoma of the prostate complicated with meningeal carcinomatosis. 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In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and hormonal therapy had been administered. Following an increase in the level of pro-gastrin-releasing peptide (ProGRP), combined chemotherapy with cisplatin plus etoposide was implemented and showed efficacy in targeting the small cell carcinoma. In March 2008, he presented with signs of meningeal irritation; his condition deteriorated quickly and multiple brain metastases were confirmed by magnetic resonance imaging (MRI). A sample of cerebrospinal fluid collected by lumbar puncture showed cancer cells and an elevated level of ProGRP. Small cell carcinoma of the prostate complicated with meningeal carcinomatosis was diagnosed. A different chemotherapy regimen was then administered, consisting of a combination of carboplatin plus irinotecan, which is one of the most common first-line treatments for extensive-stage small cell lung carcinoma. From day 20 after the initiation of this therapy, he gradually recovered from the signs of meningeal irritation, and brain MRI showed nearly normal findings; also, the serum level of ProGRP was reduced. In conclusion, we report the efficacy of combined treatment with carboplatin plus irinotecan for small cell carcinoma of the prostate complicated with meningeal carcinomatosis. Because this clinical condition is extremely rare, a gold standard treatment has yet to be established.</description><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biomarkers, Tumor - blood</subject><subject>Brain cancer</subject><subject>Camptothecin - administration & dosage</subject><subject>Camptothecin - analogs & derivatives</subject><subject>Cancer Research</subject><subject>Carboplatin - administration & dosage</subject><subject>Carcinoma, Small Cell - cerebrospinal fluid</subject><subject>Carcinoma, Small Cell - drug therapy</subject><subject>Carcinoma, Small Cell - metabolism</subject><subject>Carcinoma, Small Cell - secondary</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Chemotherapy</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningeal Carcinomatosis - cerebrospinal fluid</subject><subject>Meningeal Carcinomatosis - drug therapy</subject><subject>Meningeal Carcinomatosis - metabolism</subject><subject>Meningeal Carcinomatosis - secondary</subject><subject>Metastasis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Oncology</subject><subject>Peptide Fragments - blood</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - cerebrospinal fluid</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Recombinant Proteins - blood</subject><subject>Spinal Puncture</subject><subject>Surgical Oncology</subject><subject>Treatment Outcome</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU2L1TAUhosozjj6A9xIcKGraj7apFnKZfyAATe6Dkl66s3QNjVJHe5f89d5ai-MCLpJAnne93y8VfWc0TeMUvU2M8oaVVPa1bSTutYPqkvWCFUrpfhDfIuG1Vry9qJ6kvMtpUzJlj-uLpjuWkklvax-HuLkwgw98UeYYjlCssuJ3IVyJN4mF5fRljCTZVwzCSnMsYC3M8nHeIeiwf6IyboRCAxD8NafCMKWLCiCuew-CUa7ZKTzZMeReNgOmzyaTZbEgWBVsqSYiy1AfJyWEa0KCn7LJ5jD_A3sH6ISc8hPq0eDHTM8O99X1df3118OH-ubzx8-Hd7d1L5lvNQN8N451XqgLW2sbHzDpNZq4FYPVDihpehZ34mudV72wrPeUk0H4WBoXQfiqnq9-2KL31fIxUwhb0PYGeKajcItUyoFR_LVf0nOONcdZwi-_Au8jWuacQrDqdAcG9_c2A55XE1OMJglhcmmk2HUbPmbPX-D-Zstf6NR8-JsvLoJ-nvFOXAE-A5k_MKtpvvK_3b9BQ6kv_0</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Yamada, Tadaaki</creator><creator>Ohtsubo, Koushiro</creator><creator>Mouri, Hisatsugu</creator><creator>Yamashita, Kaname</creator><creator>Yasumoto, Kazuo</creator><creator>Izumi, Kouji</creator><creator>Zen, Yoh</creator><creator>Watanabe, Hiroyuki</creator><creator>Yano, Seiji</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosis</title><author>Yamada, Tadaaki ; Ohtsubo, Koushiro ; Mouri, Hisatsugu ; Yamashita, Kaname ; Yasumoto, Kazuo ; Izumi, Kouji ; Zen, Yoh ; Watanabe, Hiroyuki ; Yano, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-4e2dbb75ce0504a64c416997f2a9f03b3963d1d8385bc6d3c1da090f3bef5b8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - 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blood</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - cerebrospinal fluid</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Recombinant Proteins - blood</topic><topic>Spinal Puncture</topic><topic>Surgical Oncology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Tadaaki</creatorcontrib><creatorcontrib>Ohtsubo, Koushiro</creatorcontrib><creatorcontrib>Mouri, Hisatsugu</creatorcontrib><creatorcontrib>Yamashita, Kaname</creatorcontrib><creatorcontrib>Yasumoto, Kazuo</creatorcontrib><creatorcontrib>Izumi, Kouji</creatorcontrib><creatorcontrib>Zen, Yoh</creatorcontrib><creatorcontrib>Watanabe, Hiroyuki</creatorcontrib><creatorcontrib>Yano, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Tadaaki</au><au>Ohtsubo, Koushiro</au><au>Mouri, Hisatsugu</au><au>Yamashita, Kaname</au><au>Yasumoto, Kazuo</au><au>Izumi, Kouji</au><au>Zen, Yoh</au><au>Watanabe, Hiroyuki</au><au>Yano, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosis</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><addtitle>Int J Clin Oncol</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>14</volume><issue>5</issue><spage>468</spage><epage>472</epage><pages>468-472</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and hormonal therapy had been administered. Following an increase in the level of pro-gastrin-releasing peptide (ProGRP), combined chemotherapy with cisplatin plus etoposide was implemented and showed efficacy in targeting the small cell carcinoma. In March 2008, he presented with signs of meningeal irritation; his condition deteriorated quickly and multiple brain metastases were confirmed by magnetic resonance imaging (MRI). A sample of cerebrospinal fluid collected by lumbar puncture showed cancer cells and an elevated level of ProGRP. Small cell carcinoma of the prostate complicated with meningeal carcinomatosis was diagnosed. A different chemotherapy regimen was then administered, consisting of a combination of carboplatin plus irinotecan, which is one of the most common first-line treatments for extensive-stage small cell lung carcinoma. From day 20 after the initiation of this therapy, he gradually recovered from the signs of meningeal irritation, and brain MRI showed nearly normal findings; also, the serum level of ProGRP was reduced. In conclusion, we report the efficacy of combined treatment with carboplatin plus irinotecan for small cell carcinoma of the prostate complicated with meningeal carcinomatosis. Because this clinical condition is extremely rare, a gold standard treatment has yet to be established.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>19856060</pmid><doi>10.1007/s10147-008-0869-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - blood Brain cancer Camptothecin - administration & dosage Camptothecin - analogs & derivatives Cancer Research Carboplatin - administration & dosage Carcinoma, Small Cell - cerebrospinal fluid Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - secondary Case Report Case studies Chemotherapy Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Meningeal Carcinomatosis - cerebrospinal fluid Meningeal Carcinomatosis - drug therapy Meningeal Carcinomatosis - metabolism Meningeal Carcinomatosis - secondary Metastasis Neoplasm Recurrence, Local Oncology Peptide Fragments - blood Prostate cancer Prostatic Neoplasms - cerebrospinal fluid Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Recombinant Proteins - blood Spinal Puncture Surgical Oncology Treatment Outcome |
| title | Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosis |
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