microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases
microRNAs, small non-coding RNAs that regulate gene expression at the post-transcriptional level, are emerging as important regulatory molecules involved in the fine-tuning of gene expression during neuronal development and function. microRNAs have roles during neuronal stem cell commitment and earl...
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| Veröffentlicht in: | Neuroscience letters 2009-12, Vol.466 (2), p.55-62 |
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| container_title | Neuroscience letters |
| container_volume | 466 |
| creator | Christensen, Mette Schratt, Gerhard M. |
| description | microRNAs, small non-coding RNAs that regulate gene expression at the post-transcriptional level, are emerging as important regulatory molecules involved in the fine-tuning of gene expression during neuronal development and function. microRNAs have roles during neuronal stem cell commitment and early differentiation as well as in later stages of neuronal development, such as dendritogenesis and synaptic plasticity. A link between microRNAs and neurological diseases, such as neurodegeneration or synaptic dysfunction, is becoming increasingly clear. This review summarizes the current knowledge of the function of microRNAs in the developing and adult nervous system and their potential contribution to the etiology of neurological diseases. |
| doi_str_mv | 10.1016/j.neulet.2009.04.043 |
| format | Article |
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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2009-12, Vol.466 (2), p.55-62 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Differentiation Gene Expression Regulation, Developmental Humans microRNAs MicroRNAs - physiology Nervous system Nervous System - growth & development Nervous System - metabolism Nervous System Diseases - etiology Nervous System Diseases - genetics Nervous System Diseases - metabolism Neurological diseases Plasticity |
| title | microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases |
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