Indoleamine 2,3-Dioxygenase in Lung Allograft Tolerance

Background Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the degradation of tryptophan (Try) to kynurenine (Kyn), is thought to suppress T-cell activity. Although a few experimental studies have suggested a role for IDO in graft acceptance, human data are scarce and inconclusive. We sough...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2009-11, Vol.28 (11), p.1185-1192
Hauptverfasser:	Meloni, Federica, MD, PhD, Giuliano, Serena, ScD, Solari, Nadia, ScD, PhD, Draghi, Paola, ScD, Miserere, Simona, ScD, Bardoni, Anna Maria, ScD, Salvini, Roberta, ScD, Bini, Francesco, MD, Fietta, Anna Maria, ScD
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers - blood Bronchiolitis Obliterans - blood Bronchiolitis Obliterans - enzymology Cardiology. Vascular system Chromatography, High Pressure Liquid Enzyme-Linked Immunosorbent Assay Flow Cytometry Follow-Up Studies Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - blood Interleukin-8 - blood Kynurenine - blood Lung Transplantation - physiology Medical sciences Postoperative Complications - blood Postoperative Complications - enzymology Reference Values Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart T-Lymphocyte Subsets - enzymology Time Factors Transplantation Tolerance - physiology Transplantation, Homologous - physiology Tryptophan - blood
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