Pyranocoumarins: A new class of anti-hyperglycemic and anti-dyslipidemic agents

A series of pyranocoumarin derivatives were synthesized and evaluated in vivo for their anti-hyperglycemic as well as anti-dyslipidemic activities. Compounds 7a, 7c, 8a, 8b, 8c, 8e and 8f have shown promising anti-hyperglycemic activities in sucrose loaded model (SLM) as well as sucrose challenged s...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-11, Vol.19 (22), p.6447-6451
Hauptverfasser:	Kumar, Atul, Maurya, Ram Awatar, Sharma, Siddharth, Ahmad, Pervez, Singh, A.B., Bhatia, Gitika, Srivastava, Arvind K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-dyslipidemic Anti-hyperglycemic Biological and medical sciences Blood Glucose Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Dyslipidemias - blood Dyslipidemias - drug therapy General and cellular metabolism. Vitamins Hypoglycemic Agents - classification Hypoglycemic Agents - therapeutic use Lipid Metabolism - drug effects Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments PPAR gamma - metabolism PTP 1B Pyranocoumarins Pyranocoumarins - metabolism Pyranocoumarins - therapeutic use Rats Rats, Wistar Structure-Activity Relationship
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