Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

Novel amide derivatives of non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity and the deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity. Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Som...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-11, Vol.19 (22), p.6303-6306
Hauptverfasser:	Jung, Mankil, Park, Namsoo, Moon, Hyung-In, Lee, Yongnam, Chung, Won-Yoon, Park, Kwang-Kyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals - chemistry Amides - chemical synthesis Amides - chemistry Animals Antiangiogenesis Anticancer activity Antineoplastic agents Apoptosis - drug effects Apoptosis - physiology Artemisinins - chemical synthesis Artemisinins - chemistry Biological and medical sciences Cell Proliferation Deoxoartemisinin Drug Design Drug Screening Assays, Antitumor - methods Endothelium, Vascular - drug effects Endothelium, Vascular - pathology General aspects Humans Inhibitory Concentration 50 Medical sciences Mice Mice, Nude Neoplasm Transplantation Non-acetal type Pharmacology. Drug treatments Structure-Activity Relationship
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