Infrared Photoactivation Reduces Peptide Folding and Hydrogen-Atom Migration following ETD Tandem Mass Spectrometry
Peptides see the light: The photoactivation of peptide precursor cations during electron transfer dissociation (ETD) led to the generation of isotopic cluster peaks that more closely resembled theoretically predicted product‐ion distributions. This method should enable the application of ETD to low‐...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2009-01, Vol.48 (45), p.8526-8528 |
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| container_issue | 45 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 48 |
| creator | Ledvina, Aaron R McAlister, Graeme C Gardner, Myles W Smith, Suncerae I Madsen, James A Schwartz, Jae C Stafford, George C. Jr Syka, John E.P Brodbelt, Jennifer S Coon, Joshua J |
| description | Peptides see the light: The photoactivation of peptide precursor cations during electron transfer dissociation (ETD) led to the generation of isotopic cluster peaks that more closely resembled theoretically predicted product‐ion distributions. This method should enable the application of ETD to low‐charge‐density peptide precursors, the gas‐phase secondary structure of which prevents the direct formation of c‐ and z.‐type fragment ions. |
| doi_str_mv | 10.1002/anie.200903557 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2009-01, Vol.48 (45), p.8526-8528 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | ionization of gases mass spectrometry peptides Peptides - chemistry photoactivation Photochemical Processes proteomics Tandem Mass Spectrometry - methods Ultraviolet Rays |
| title | Infrared Photoactivation Reduces Peptide Folding and Hydrogen-Atom Migration following ETD Tandem Mass Spectrometry |
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