Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors

Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors and the SAR requirements are reported. Secreted frizzled related protein-1 (sFRP-1) inhibitors have the potential to be used for the treatment of osteoporosis or other bone related disorders, since the level of...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-11, Vol.19 (22), p.6337-6339
Hauptverfasser:	Shi, Mengxiao, Stauffer, Barbara, Bhat, Ramesh, Billiard, Julia, Ponce-de-Leon, Helga, Seestaller-Wehr, Laura, Fukayama, Shoichi, Mangine, Annamarie, Moran, Robert, Krishnamurthy, Girija, Bodine, Peter, Gopalsamy, Ariamala
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Calcification, Physiologic Cell Differentiation - physiology Cells, Cultured Frizzled Receptors - antagonists & inhibitors Frizzled Receptors - isolation & purification Medical sciences Molecular Structure Osteogenesis - physiology Pharmacology. Drug treatments Proteins - antagonists & inhibitors Proteins - isolation & purification RANK Ligand sFRP1 inhibitor osteoporosis
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