Global vitamin D status and determinants of hypovitaminosis D
Summary This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures. Introduction Vitamin D st...
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| Veröffentlicht in: | Osteoporosis international 2009-11, Vol.20 (11), p.1807-1820 |
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| creator | Mithal, A Wahl, D. A Bonjour, J.-P Burckhardt, P Dawson-Hughes, B Eisman, J. A El-Hajj Fuleihan, G Josse, R. G Lips, P Morales-Torres, J |
| description | Summary This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures. Introduction Vitamin D status has been linked to the pathogenesis of hip fractures as well as other skeletal and non-skeletal disorders. The purpose of this review is to provide a global perspective of vitamin D status across different regions of the world and to identify the common and significant determinants of hypovitaminosis D. Methods Six regions of the world were reviewed—Asia, Europe, Middle East and Africa, Latin America, North America, and Oceania—through a survey of published literature. Results The definition of vitamin D insufficiency and deficiency, as well as assay methodology for 25-hydroxyvitamin D or 25(OH)D, vary between studies. However, serum 25(OH)D levels below 75 nmol/L are prevalent in every region studied whilst levels below 25 nmol/L are most common in regions such as South Asia and the Middle East. Older age, female sex, higher latitude, winter season, darker skin pigmentation, less sunlight exposure, dietary habits, and absence of vitamin D fortification are the main factors that are significantly associated with lower 25(OH)D levels. Conclusion Reports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally. |
| doi_str_mv | 10.1007/s00198-009-0954-6 |
| format | Article |
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A ; Bonjour, J.-P ; Burckhardt, P ; Dawson-Hughes, B ; Eisman, J. A ; El-Hajj Fuleihan, G ; Josse, R. G ; Lips, P ; Morales-Torres, J</creator><creatorcontrib>Mithal, A ; Wahl, D. A ; Bonjour, J.-P ; Burckhardt, P ; Dawson-Hughes, B ; Eisman, J. A ; El-Hajj Fuleihan, G ; Josse, R. G ; Lips, P ; Morales-Torres, J ; IOF Committee of Scientific Advisors (CSA) Nutrition Working Group ; on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group</creatorcontrib><description>Summary This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures. Introduction Vitamin D status has been linked to the pathogenesis of hip fractures as well as other skeletal and non-skeletal disorders. The purpose of this review is to provide a global perspective of vitamin D status across different regions of the world and to identify the common and significant determinants of hypovitaminosis D. Methods Six regions of the world were reviewed—Asia, Europe, Middle East and Africa, Latin America, North America, and Oceania—through a survey of published literature. Results The definition of vitamin D insufficiency and deficiency, as well as assay methodology for 25-hydroxyvitamin D or 25(OH)D, vary between studies. However, serum 25(OH)D levels below 75 nmol/L are prevalent in every region studied whilst levels below 25 nmol/L are most common in regions such as South Asia and the Middle East. Older age, female sex, higher latitude, winter season, darker skin pigmentation, less sunlight exposure, dietary habits, and absence of vitamin D fortification are the main factors that are significantly associated with lower 25(OH)D levels. Conclusion Reports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-009-0954-6</identifier><identifier>PMID: 19543765</identifier><language>eng</language><publisher>London: London : Springer-Verlag</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Biological and medical sciences ; Child ; Child, Preschool ; Cross-Cultural Comparison ; Diseases of the osteoarticular system ; Endocrinology ; Female ; Fractures ; Genetic Predisposition to Disease ; Global Health ; Humans ; Infant ; Infant, Newborn ; International ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Orthopedics ; Osteoporosis ; Osteoporosis. Osteomalacia. Paget disease ; Pathology ; Prevalence ; Review ; Rheumatology ; Risk Factors ; Sex Factors ; Vitamin D ; Vitamin D - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - etiology ; Vitamin deficiency ; Young Adult</subject><ispartof>Osteoporosis international, 2009-11, Vol.20 (11), p.1807-1820</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-e3f4335062a3091db0a5e0d94b52093e41dca82ea57543aeef3a14f43f2b894d3</citedby><cites>FETCH-LOGICAL-c498t-e3f4335062a3091db0a5e0d94b52093e41dca82ea57543aeef3a14f43f2b894d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-009-0954-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-009-0954-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22076256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19543765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mithal, A</creatorcontrib><creatorcontrib>Wahl, D. A</creatorcontrib><creatorcontrib>Bonjour, J.-P</creatorcontrib><creatorcontrib>Burckhardt, P</creatorcontrib><creatorcontrib>Dawson-Hughes, B</creatorcontrib><creatorcontrib>Eisman, J. A</creatorcontrib><creatorcontrib>El-Hajj Fuleihan, G</creatorcontrib><creatorcontrib>Josse, R. G</creatorcontrib><creatorcontrib>Lips, P</creatorcontrib><creatorcontrib>Morales-Torres, J</creatorcontrib><creatorcontrib>IOF Committee of Scientific Advisors (CSA) Nutrition Working Group</creatorcontrib><creatorcontrib>on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group</creatorcontrib><title>Global vitamin D status and determinants of hypovitaminosis D</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures. Introduction Vitamin D status has been linked to the pathogenesis of hip fractures as well as other skeletal and non-skeletal disorders. The purpose of this review is to provide a global perspective of vitamin D status across different regions of the world and to identify the common and significant determinants of hypovitaminosis D. Methods Six regions of the world were reviewed—Asia, Europe, Middle East and Africa, Latin America, North America, and Oceania—through a survey of published literature. Results The definition of vitamin D insufficiency and deficiency, as well as assay methodology for 25-hydroxyvitamin D or 25(OH)D, vary between studies. However, serum 25(OH)D levels below 75 nmol/L are prevalent in every region studied whilst levels below 25 nmol/L are most common in regions such as South Asia and the Middle East. Older age, female sex, higher latitude, winter season, darker skin pigmentation, less sunlight exposure, dietary habits, and absence of vitamin D fortification are the main factors that are significantly associated with lower 25(OH)D levels. Conclusion Reports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Cultural Comparison</subject><subject>Diseases of the osteoarticular system</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fractures</subject><subject>Genetic Predisposition to Disease</subject><subject>Global Health</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>International</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Pathology</subject><subject>Prevalence</subject><subject>Review</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - etiology</subject><subject>Vitamin deficiency</subject><subject>Young Adult</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtr3TAQhUVpSG7S_oBuWlNIsnIzetiyFl2UvOFCF82F7sTYllMHX-tWYwfy7yNjk0AWWQlG3zlzpMPYFw4_OIA-IwBuihTApGAyleYf2IorKVNh8uwjW4GROjWK_z1gh0QPEDXG6H12wCMtdZ6t2M_rzpfYJY_tgNu2Ty4SGnAYKcG-Tmo3uBCn2A-U-Cb597TzC-ippeTiE9trsCP3eTmP2Obq8u78Jl3_vr49_7VOK2WKIXWyiakyyAVKMLwuATMHtVFlJmJGp3hdYSEcZjrmQucaiVxFTSPKwqhaHrHT2XcX_P_R0WC3LVWu67B3fiSrpQKjtYZInrxLCi5EYUwewe9vwAc_hj6-IjJFkUulJ4jPUBU8UXCN3YV2i-HJcrBTBXauwMYK7FSBnTRfF-Ox3Lr6VbH8eQSOFwCpwq4J2FctvXBCgM5FNhmJmaN41d-78Jrwve3fZlGD3uJ9iMabPwK4BJ5HAkA-A-4gpYU</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Mithal, A</creator><creator>Wahl, D. 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G</creator><creator>Lips, P</creator><creator>Morales-Torres, J</creator><general>London : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Global vitamin D status and determinants of hypovitaminosis D</title><author>Mithal, A ; Wahl, D. A ; Bonjour, J.-P ; Burckhardt, P ; Dawson-Hughes, B ; Eisman, J. A ; El-Hajj Fuleihan, G ; Josse, R. G ; Lips, P ; Morales-Torres, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-e3f4335062a3091db0a5e0d94b52093e41dca82ea57543aeef3a14f43f2b894d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Cultural Comparison</topic><topic>Diseases of the osteoarticular system</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fractures</topic><topic>Genetic Predisposition to Disease</topic><topic>Global Health</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>International</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Pathology</topic><topic>Prevalence</topic><topic>Review</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - etiology</topic><topic>Vitamin deficiency</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mithal, A</creatorcontrib><creatorcontrib>Wahl, D. A</creatorcontrib><creatorcontrib>Bonjour, J.-P</creatorcontrib><creatorcontrib>Burckhardt, P</creatorcontrib><creatorcontrib>Dawson-Hughes, B</creatorcontrib><creatorcontrib>Eisman, J. A</creatorcontrib><creatorcontrib>El-Hajj Fuleihan, G</creatorcontrib><creatorcontrib>Josse, R. G</creatorcontrib><creatorcontrib>Lips, P</creatorcontrib><creatorcontrib>Morales-Torres, J</creatorcontrib><creatorcontrib>IOF Committee of Scientific Advisors (CSA) Nutrition Working Group</creatorcontrib><creatorcontrib>on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mithal, A</au><au>Wahl, D. A</au><au>Bonjour, J.-P</au><au>Burckhardt, P</au><au>Dawson-Hughes, B</au><au>Eisman, J. A</au><au>El-Hajj Fuleihan, G</au><au>Josse, R. G</au><au>Lips, P</au><au>Morales-Torres, J</au><aucorp>IOF Committee of Scientific Advisors (CSA) Nutrition Working Group</aucorp><aucorp>on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Global vitamin D status and determinants of hypovitaminosis D</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>20</volume><issue>11</issue><spage>1807</spage><epage>1820</epage><pages>1807-1820</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures. Introduction Vitamin D status has been linked to the pathogenesis of hip fractures as well as other skeletal and non-skeletal disorders. The purpose of this review is to provide a global perspective of vitamin D status across different regions of the world and to identify the common and significant determinants of hypovitaminosis D. Methods Six regions of the world were reviewed—Asia, Europe, Middle East and Africa, Latin America, North America, and Oceania—through a survey of published literature. Results The definition of vitamin D insufficiency and deficiency, as well as assay methodology for 25-hydroxyvitamin D or 25(OH)D, vary between studies. However, serum 25(OH)D levels below 75 nmol/L are prevalent in every region studied whilst levels below 25 nmol/L are most common in regions such as South Asia and the Middle East. Older age, female sex, higher latitude, winter season, darker skin pigmentation, less sunlight exposure, dietary habits, and absence of vitamin D fortification are the main factors that are significantly associated with lower 25(OH)D levels. Conclusion Reports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally.</abstract><cop>London</cop><pub>London : Springer-Verlag</pub><pmid>19543765</pmid><doi>10.1007/s00198-009-0954-6</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Biological and medical sciences Child Child, Preschool Cross-Cultural Comparison Diseases of the osteoarticular system Endocrinology Female Fractures Genetic Predisposition to Disease Global Health Humans Infant Infant, Newborn International Male Medical sciences Medicine Medicine & Public Health Middle Aged Orthopedics Osteoporosis Osteoporosis. Osteomalacia. Paget disease Pathology Prevalence Review Rheumatology Risk Factors Sex Factors Vitamin D Vitamin D - blood Vitamin D Deficiency - epidemiology Vitamin D Deficiency - etiology Vitamin deficiency Young Adult |
| title | Global vitamin D status and determinants of hypovitaminosis D |
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