Structure of the Amyloid-β (1−42) Monomer Absorbed To Model Phospholipid Bilayers: A Molecular Dynamics Study

The amyloid-β (Aβ) peptide, the 39 to 43 amino acid peptide that plays a substantial role in Alzheimer’s disease, has been shown to interact strongly with lipids both in vitro and in vivo. Aβ−lipid interactions have been proposed as a considerable factor in accelerating Aβ aggregation through the te...

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Veröffentlicht in:	The journal of physical chemistry. B 2009-10, Vol.113 (43), p.14480-14486
Hauptverfasser:	Davis, Charles H, Berkowitz, Max L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - chemistry B: Biophysical Chemistry Lipid Bilayers - chemistry Models, Chemical Molecular Dynamics Simulation Peptide Fragments - chemistry Phospholipids - chemistry Protein Binding Protein Structure, Tertiary
Online-Zugang:	Volltext
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