The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus
Researchers have extensively used animal models to study diabetes mellitus. In this study, the authors determined the susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. For 8 months, the researchers fed Nongda control minipigs ( n = 4) a normal diet and fed...
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| Veröffentlicht in: | Lab animal 2009-11, Vol.38 (11), p.355-363 |
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| creator | Chen, Hua Liu, Ya-qian Li, Chun-hai Guo, Xiong-ming Huang, Li-jie |
| description | Researchers have extensively used animal models to study diabetes mellitus. In this study, the authors determined the susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. For 8 months, the researchers fed Nongda control minipigs (
n
= 4) a normal diet and fed Bama, Wuzhishan and Nongda minipigs (
n
= 6 per group) a high-sucrose, high-fat diet. They measured the minipigs' body weights, fasting serum glucose concentrations and insulin concentrations each month. Every 2 months, they measured serum triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and carried out intravenous glucose tolerance tests (IVGTTs). The Bama and Wuzhishan minipigs were relatively susceptible to diabetes induced by the high-sucrose, high-fat diet, though susceptibility differed among individual animals in the same strain. On the other hand, Nongda minipigs were relatively resistant to diet-induced diabetes. These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes. |
| doi_str_mv | 10.1038/laban1109-355 |
| format | Article |
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n
= 4) a normal diet and fed Bama, Wuzhishan and Nongda minipigs (
n
= 6 per group) a high-sucrose, high-fat diet. They measured the minipigs' body weights, fasting serum glucose concentrations and insulin concentrations each month. Every 2 months, they measured serum triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and carried out intravenous glucose tolerance tests (IVGTTs). The Bama and Wuzhishan minipigs were relatively susceptible to diabetes induced by the high-sucrose, high-fat diet, though susceptibility differed among individual animals in the same strain. On the other hand, Nongda minipigs were relatively resistant to diet-induced diabetes. These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes.</description><identifier>ISSN: 0093-7355</identifier><identifier>EISSN: 1548-4475</identifier><identifier>DOI: 10.1038/laban1109-355</identifier><identifier>PMID: 19847179</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animal Models ; Animals ; Biomedical and Life Sciences ; Blood Glucose - metabolism ; Body Weight - physiology ; Cholesterol - blood ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - metabolism ; Diet ; Disease Models, Animal ; Disease susceptibility ; Female ; Genetic Predisposition to Disease ; Glucose Tolerance Test ; Health aspects ; Insulin - blood ; Insulin Resistance - physiology ; Life Sciences ; Male ; research-note ; Risk factors ; Swine ; Swine, Miniature - genetics ; Swine, Miniature - metabolism ; Triglycerides - blood ; Type 2 diabetes ; Veterinary Medicine/Veterinary Science</subject><ispartof>Lab animal, 2009-11, Vol.38 (11), p.355-363</ispartof><rights>Springer Nature America, Inc. 2009</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-d5d265765175c6acd850c6b3c387fa29ec376f1e197ae6c1cf0eed14eaf11b703</citedby><cites>FETCH-LOGICAL-c520t-d5d265765175c6acd850c6b3c387fa29ec376f1e197ae6c1cf0eed14eaf11b703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/laban1109-355$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/laban1109-355$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19847179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hua</creatorcontrib><creatorcontrib>Liu, Ya-qian</creatorcontrib><creatorcontrib>Li, Chun-hai</creatorcontrib><creatorcontrib>Guo, Xiong-ming</creatorcontrib><creatorcontrib>Huang, Li-jie</creatorcontrib><title>The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus</title><title>Lab animal</title><addtitle>Lab Anim</addtitle><addtitle>Lab Anim (NY)</addtitle><description>Researchers have extensively used animal models to study diabetes mellitus. In this study, the authors determined the susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. For 8 months, the researchers fed Nongda control minipigs (
n
= 4) a normal diet and fed Bama, Wuzhishan and Nongda minipigs (
n
= 6 per group) a high-sucrose, high-fat diet. They measured the minipigs' body weights, fasting serum glucose concentrations and insulin concentrations each month. Every 2 months, they measured serum triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and carried out intravenous glucose tolerance tests (IVGTTs). The Bama and Wuzhishan minipigs were relatively susceptible to diabetes induced by the high-sucrose, high-fat diet, though susceptibility differed among individual animals in the same strain. On the other hand, Nongda minipigs were relatively resistant to diet-induced diabetes. These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes.</description><subject>Animal Models</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight - physiology</subject><subject>Cholesterol - blood</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>Disease susceptibility</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Glucose Tolerance Test</subject><subject>Health aspects</subject><subject>Insulin - blood</subject><subject>Insulin Resistance - physiology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>research-note</subject><subject>Risk factors</subject><subject>Swine</subject><subject>Swine, Miniature - genetics</subject><subject>Swine, Miniature - metabolism</subject><subject>Triglycerides - blood</subject><subject>Type 2 diabetes</subject><subject>Veterinary Medicine/Veterinary Science</subject><issn>0093-7355</issn><issn>1548-4475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UkGP1CAYJUbjzq4evZomHjx15SsFynEzUddkEy_rGSl8nWHT0gr0MP9eJjvZcY2GA8njfY_3eBDyDug1UNZ9Gk1vAgBVNeP8BdkAb7u6bSV_STaUKlbLgl-Qy5QeKGUAir4mF6C6VoJUG_Lzfo9VWpPFJfvejz4fqnmo8j5iwXM0PqQjsN37gAmryQe_-F2q8lw5j7n2wa0WXZUPC1ZNwUyPGVM14VjE1vSGvBrMmPDtab8iP758vt_e1nffv37b3tzVljc01467RnApOEhuhbGu49SKnlnWycE0Ci2TYgAEJQ0KC3agiA5aNANALym7Ih8fdZc4_1oxZT35kmocTcB5TVqylirRSVaYH_5iPsxrDMWcBtlJqngnxJm1MyNqH4a5PIY9auqbBmgnit7x1ut_sMpyOHk7Bxx8wZ8N1I8DNs4pRRz0Ev1k4kED1cdC9VOhuhRX-O9PZtd-Qndmnxo8O0jlKOww_pHmP4qnYMHkNeKT4rOPxH4Dkaq2MA</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Chen, Hua</creator><creator>Liu, Ya-qian</creator><creator>Li, Chun-hai</creator><creator>Guo, Xiong-ming</creator><creator>Huang, Li-jie</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus</title><author>Chen, Hua ; Liu, Ya-qian ; Li, Chun-hai ; Guo, Xiong-ming ; Huang, Li-jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-d5d265765175c6acd850c6b3c387fa29ec376f1e197ae6c1cf0eed14eaf11b703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animal Models</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight - physiology</topic><topic>Cholesterol - blood</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diet</topic><topic>Disease Models, Animal</topic><topic>Disease susceptibility</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Glucose Tolerance Test</topic><topic>Health aspects</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - physiology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>research-note</topic><topic>Risk factors</topic><topic>Swine</topic><topic>Swine, Miniature - genetics</topic><topic>Swine, Miniature - metabolism</topic><topic>Triglycerides - blood</topic><topic>Type 2 diabetes</topic><topic>Veterinary Medicine/Veterinary Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hua</creatorcontrib><creatorcontrib>Liu, Ya-qian</creatorcontrib><creatorcontrib>Li, Chun-hai</creatorcontrib><creatorcontrib>Guo, Xiong-ming</creatorcontrib><creatorcontrib>Huang, Li-jie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lab animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hua</au><au>Liu, Ya-qian</au><au>Li, Chun-hai</au><au>Guo, Xiong-ming</au><au>Huang, Li-jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus</atitle><jtitle>Lab animal</jtitle><stitle>Lab Anim</stitle><addtitle>Lab Anim (NY)</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>38</volume><issue>11</issue><spage>355</spage><epage>363</epage><pages>355-363</pages><issn>0093-7355</issn><eissn>1548-4475</eissn><abstract>Researchers have extensively used animal models to study diabetes mellitus. In this study, the authors determined the susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. For 8 months, the researchers fed Nongda control minipigs (
n
= 4) a normal diet and fed Bama, Wuzhishan and Nongda minipigs (
n
= 6 per group) a high-sucrose, high-fat diet. They measured the minipigs' body weights, fasting serum glucose concentrations and insulin concentrations each month. Every 2 months, they measured serum triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and carried out intravenous glucose tolerance tests (IVGTTs). The Bama and Wuzhishan minipigs were relatively susceptible to diabetes induced by the high-sucrose, high-fat diet, though susceptibility differed among individual animals in the same strain. On the other hand, Nongda minipigs were relatively resistant to diet-induced diabetes. These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>19847179</pmid><doi>10.1038/laban1109-355</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| subjects | Animal Models Animals Biomedical and Life Sciences Blood Glucose - metabolism Body Weight - physiology Cholesterol - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diet Disease Models, Animal Disease susceptibility Female Genetic Predisposition to Disease Glucose Tolerance Test Health aspects Insulin - blood Insulin Resistance - physiology Life Sciences Male research-note Risk factors Swine Swine, Miniature - genetics Swine, Miniature - metabolism Triglycerides - blood Type 2 diabetes Veterinary Medicine/Veterinary Science |
| title | The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus |
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