Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients

Aim The pathophysiology of delirium remains elusive though neurotransmitters and their precursor large neutral amino acids (LNAAs) may play a role. This pilot study investigated whether alterations of tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) plasma levels were associated with a high...

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Veröffentlicht in:	Intensive care medicine 2009-11, Vol.35 (11), p.1886-1892
Hauptverfasser:	Pandharipande, P. P., Morandi, A., Adams, J. R., Girard, T. D., Thompson, J. L., Shintani, A. K., Ely, E. Wesley
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amino Acid Transport System L - blood Amino acids Analysis of Variance Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Biological and medical sciences Blood-brain barrier Brain research Clinical death. Palliative care. Organ gift and preservation Clinical trials Cognitive ability Critical care Critical Care Medicine Critical Illness Delirium Delirium - blood Delirium - diagnosis Delirium - etiology Disease Progression Emergency Medicine Female Humans Intensive Intensive care Intensive care medicine Logistic Models Male Markov Chains Medical sciences Medicine Medicine & Public Health Middle Aged Neurotransmitters Original Pain Medicine Pathophysiology Pediatrics Phenylalanine - blood Pilot Projects Plasma Pneumology/Respiratory System Predictive Value of Tests Ratios Regression Analysis Risk Assessment Risk Factors Serotonin Severity of Illness Index Tennessee Time Factors Tryptophan - blood Tryptophan - deficiency Tyrosine - blood Tyrosine - deficiency
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