efflux transporter PbrA and a phosphatase PbrB cooperate in a lead-resistance mechanism in bacteria

The gene cluster pbrTRABCD from Cupriavidus metallidurans CH34 is thought to encode a unique, specific resistance mechanism for lead. However, the exact functions of these genes are unknown. In this study we examine the metal specificity and functions of pbrABCD by expressing these genes in differen...

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Veröffentlicht in:	Molecular microbiology 2009-10, Vol.74 (2), p.384-394
Hauptverfasser:	Hynninen, Anu, Touzé, Thierry, Pitkänen, Leena, Mengin-Lecreulx, Dominique, Virta, Marko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological and medical sciences Cupriavidus - drug effects Cupriavidus - enzymology Cupriavidus - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Bacterial Genes Genetic Complementation Test Lead Lead - pharmacology Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Microbiology Multigene Family Operon Pyrophosphatases - genetics Pyrophosphatases - metabolism Studies Substrate Specificity
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