Chemoselective Staudinger-Phosphite Reaction of Azides for the Phosphorylation of Proteins

Extending the toolbox: The title reaction was identified as a chemoselective means to modify azides in peptides and proteins in high yields at room temperature in various solvents including aqueous buffers at physiological pH. In combination with nonnatural protein translation the Staudinger‐phosphi...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-10, Vol.48 (44), p.8234-8239
Hauptverfasser:	Serwa, Remigiusz, Wilkening, Ina, Del Signore, Giuseppe, Mühlberg, Michaela, Claußnitzer, Iris, Weise, Christoph, Gerrits, Michael, Hackenberger, Christian P.R
Format:	Artikel
Sprache:	eng
Schlagworte:	azides Azides - chemistry Bacterial Proteins - chemistry Bacterial Proteins - metabolism chemoselectivity phosphites Phosphites - chemistry Phosphorylation Staudinger reaction Tyrosine - chemistry
Online-Zugang:	Volltext
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