Diverse Prognostic Roles of Akt Isoforms, PTEN and PI3K in Tumor Epithelial Cells and Stromal Compartment in Non-small Cell Lung Cancer

Aim: By tissue microarray methodology, the expression of altered Akt isoforms, PTEN and PI3K and their prognostic significance in 335 non-small cell lung cancer (NSCLC) tumors were investigated. Patients and Methods: Tumor tissue was sampled and immunohistochemicaly quantified in 335 tumors from sta...

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Veröffentlicht in:	Anticancer research 2009-10, Vol.29 (10), p.4175-4183
Hauptverfasser:	Al-Saad, Samer, Donnem, Tom, Al-Shibli, Khalid, Persson, Magnus, Bremnes, Roy M, Busund, Lill-Tove
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Epithelial Cells - enzymology Epithelial Cells - pathology Humans Immunohistochemistry Isoenzymes Lung Neoplasms - enzymology Lung Neoplasms - pathology Medical sciences Middle Aged Neoplasm Staging Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Pneumology Prognosis Proportional Hazards Models Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism Signal Transduction Stromal Cells - enzymology Stromal Cells - pathology Tumors Tumors of the respiratory system and mediastinum
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