Synthesis of Pyridines and Pyrazines Using an Intramolecular Hydroamination-Based Reaction Sequence

A management issue! Various pyridines and pyrazines can be efficiently accessed from simple acyclic precursors using an intramolecular hydroamination/isomerization/aromatization sequence (see scheme). p‐Toluenesulfonic acid (2 mol %) is used to catalyze this novel alkyne annulation, in which the oxi...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-10, Vol.48 (44), p.8325-8327
Hauptverfasser:	Rizk, Toni, Bilodeau, Eric J.-F, Beauchemin, André M
Format:	Artikel
Sprache:	eng
Schlagworte:	alkynes Amination Cyclization homogeneous catalysis hydroamination Hydroxylamines - chemistry nitrogen heterocycles Pyrazines - chemical synthesis Pyrazines - chemistry Pyridines - chemical synthesis Pyridines - chemistry sustainable chemistry
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