Perinatal risk factors for childhood obesity and metabolic dysregulation

BACKGROUND: Childhood obesity has increased significantly in recent decades. OBJECTIVE: The objective was to examine the perinatal risk factors related to childhood obesity. DESIGN: In a prospective study, 89 women with normal glucose tolerance (NGT) or gestational diabetes mellitus (GDM) and their...

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Veröffentlicht in:The American journal of clinical nutrition 2009-11, Vol.90 (5), p.1303-1313
Hauptverfasser: Catalano, Patrick M, Farrell, Kristen, Thomas, Alicia, Huston-Presley, Larraine, Mencin, Patricia, de Mouzon, Sylvie Hauguel, Amini, Saeid B
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container_end_page 1313
container_issue 5
container_start_page 1303
container_title The American journal of clinical nutrition
container_volume 90
creator Catalano, Patrick M
Farrell, Kristen
Thomas, Alicia
Huston-Presley, Larraine
Mencin, Patricia
de Mouzon, Sylvie Hauguel
Amini, Saeid B
description BACKGROUND: Childhood obesity has increased significantly in recent decades. OBJECTIVE: The objective was to examine the perinatal risk factors related to childhood obesity. DESIGN: In a prospective study, 89 women with normal glucose tolerance (NGT) or gestational diabetes mellitus (GDM) and their offspring were evaluated at birth and at 8.8 ± 1.8 y. At birth, obstetrical data, parental anthropometric measures, and neonatal body composition were assessed; at follow-up, diet and activity were assessed and laboratory studies were conducted. Weight was classified by using weight for age and sex, and body composition was measured by using dual-energy X-ray absorptiometry. In childhood, data were analyzed as tertiles and prediction models were developed by using logistic and stepwise regression. RESULTS: No significant differences in Centers for Disease Control and Prevention weight percentiles, body composition, and most metabolic measures were observed between children of mothers with NGT and GDM at follow-up. Children in the upper tertile for weight had greater energy intake (P = 0.02), skinfold thickness (P = 0.0001), and leptin concentrations (P < 0.0001) than did those in tertiles 1 and 2. Children in the upper tertile for percentage body fat had greater waist circumference (P = 0.0001), insulin resistance (P = 0.002), and triglyceride (P = 0.009) and leptin (P = 0.0001) concentrations than did children in tertiles 1 and 2. The correlation between body fat at birth and follow-up was r = 0.29 (P = 0.02). The strongest perinatal predictor for a child in the upper tertile for weight was maternal pregravid body mass index (BMI; kg/m²) >30 (odds ratio: 3.75; 95% CI: 1.39, 10.10; P = 0.009) and for percentage body fat was maternal pregravid BMI >30 (odds ratio: 5.45; 95% CI: 1.62, 18.41; P = 0.006). CONCLUSION: Maternal pregravid BMI, independent of maternal glucose status or birth weight, was the strongest predictor of childhood obesity.
doi_str_mv 10.3945/ajcn.2008.27416
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OBJECTIVE: The objective was to examine the perinatal risk factors related to childhood obesity. DESIGN: In a prospective study, 89 women with normal glucose tolerance (NGT) or gestational diabetes mellitus (GDM) and their offspring were evaluated at birth and at 8.8 ± 1.8 y. At birth, obstetrical data, parental anthropometric measures, and neonatal body composition were assessed; at follow-up, diet and activity were assessed and laboratory studies were conducted. Weight was classified by using weight for age and sex, and body composition was measured by using dual-energy X-ray absorptiometry. In childhood, data were analyzed as tertiles and prediction models were developed by using logistic and stepwise regression. RESULTS: No significant differences in Centers for Disease Control and Prevention weight percentiles, body composition, and most metabolic measures were observed between children of mothers with NGT and GDM at follow-up. Children in the upper tertile for weight had greater energy intake (P = 0.02), skinfold thickness (P = 0.0001), and leptin concentrations (P &lt; 0.0001) than did those in tertiles 1 and 2. Children in the upper tertile for percentage body fat had greater waist circumference (P = 0.0001), insulin resistance (P = 0.002), and triglyceride (P = 0.009) and leptin (P = 0.0001) concentrations than did children in tertiles 1 and 2. The correlation between body fat at birth and follow-up was r = 0.29 (P = 0.02). The strongest perinatal predictor for a child in the upper tertile for weight was maternal pregravid body mass index (BMI; kg/m²) &gt;30 (odds ratio: 3.75; 95% CI: 1.39, 10.10; P = 0.009) and for percentage body fat was maternal pregravid BMI &gt;30 (odds ratio: 5.45; 95% CI: 1.62, 18.41; P = 0.006). CONCLUSION: Maternal pregravid BMI, independent of maternal glucose status or birth weight, was the strongest predictor of childhood obesity.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.2008.27416</identifier><identifier>PMID: 19759171</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adipose Tissue - anatomy &amp; histology ; Adult ; age ; Biological and medical sciences ; Birth weight ; Body Composition ; Centers for Disease Control and Prevention, U.S ; Child ; children ; Children &amp; youth ; Childrens health ; Diabetes, Gestational - blood ; disease incidence ; disease prevention ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; gestational diabetes ; Glucose Intolerance - epidemiology ; glucose tolerance ; health effects assessments ; high energy diet ; Humans ; Infant ; Infant, Newborn ; Male ; maternal effect ; Metabolic Diseases - epidemiology ; metabolic syndrome ; Mothers ; Obesity ; Obesity - epidemiology ; Odds Ratio ; Perinatal Care - standards ; perinatal period ; physical activity ; prediction ; Pregnancy ; Risk Factors ; United States ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight control ; Weight Gain - physiology</subject><ispartof>The American journal of clinical nutrition, 2009-11, Vol.90 (5), p.1303-1313</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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OBJECTIVE: The objective was to examine the perinatal risk factors related to childhood obesity. DESIGN: In a prospective study, 89 women with normal glucose tolerance (NGT) or gestational diabetes mellitus (GDM) and their offspring were evaluated at birth and at 8.8 ± 1.8 y. At birth, obstetrical data, parental anthropometric measures, and neonatal body composition were assessed; at follow-up, diet and activity were assessed and laboratory studies were conducted. Weight was classified by using weight for age and sex, and body composition was measured by using dual-energy X-ray absorptiometry. In childhood, data were analyzed as tertiles and prediction models were developed by using logistic and stepwise regression. RESULTS: No significant differences in Centers for Disease Control and Prevention weight percentiles, body composition, and most metabolic measures were observed between children of mothers with NGT and GDM at follow-up. Children in the upper tertile for weight had greater energy intake (P = 0.02), skinfold thickness (P = 0.0001), and leptin concentrations (P &lt; 0.0001) than did those in tertiles 1 and 2. Children in the upper tertile for percentage body fat had greater waist circumference (P = 0.0001), insulin resistance (P = 0.002), and triglyceride (P = 0.009) and leptin (P = 0.0001) concentrations than did children in tertiles 1 and 2. The correlation between body fat at birth and follow-up was r = 0.29 (P = 0.02). The strongest perinatal predictor for a child in the upper tertile for weight was maternal pregravid body mass index (BMI; kg/m²) &gt;30 (odds ratio: 3.75; 95% CI: 1.39, 10.10; P = 0.009) and for percentage body fat was maternal pregravid BMI &gt;30 (odds ratio: 5.45; 95% CI: 1.62, 18.41; P = 0.006). 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Psychology</subject><subject>gestational diabetes</subject><subject>Glucose Intolerance - epidemiology</subject><subject>glucose tolerance</subject><subject>health effects assessments</subject><subject>high energy diet</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>maternal effect</subject><subject>Metabolic Diseases - epidemiology</subject><subject>metabolic syndrome</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Odds Ratio</subject><subject>Perinatal Care - standards</subject><subject>perinatal period</subject><subject>physical activity</subject><subject>prediction</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>United States</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weight control</subject><subject>Weight Gain - physiology</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M9rFDEUwPEgSrutPXvTQRBPs30vPybJsRRtCwUF7Tlk8qPNOjupycxh_3tn3UWhp1w-ebz3JeQdwpppLi7txo1rCqDWVHLsXpEVaqZaRkG-JisAoK3GTpySs1o3AEi56k7IKWopNEpckdvvoaTRTnZoSqq_mmjdlEttYi6Ne0qDf8rZN7kPNU27xo6-2YbJ9nlIrvG7WsLjPNgp5fEteRPtUMPF8T0nD1-__Ly-be-_3dxdX923jis-tV52KgQfwHWxF-gd9F3vY1QMuqhopzijTLnoELWgCpWUUWiPGrlkSCU7J58Pc59L_j2HOpltqi4Mgx1DnquRjIMWyNkiP76QmzyXcVnOUIaag9CwoMsDciXX5Zxonkva2rIzCGaf2OwTm31i8zfx8uP9cezcb4P_749NF_DpCGx1dojFji7Vf45S4IBiv9-Hg4s2G_u45DcPPyggA-w05yDZHw77jKU</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Catalano, Patrick M</creator><creator>Farrell, Kristen</creator><creator>Thomas, Alicia</creator><creator>Huston-Presley, Larraine</creator><creator>Mencin, Patricia</creator><creator>de Mouzon, Sylvie Hauguel</creator><creator>Amini, Saeid B</creator><general>American Society for Clinical Nutrition</general><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Perinatal risk factors for childhood obesity and metabolic dysregulation</title><author>Catalano, Patrick M ; Farrell, Kristen ; Thomas, Alicia ; Huston-Presley, Larraine ; Mencin, Patricia ; de Mouzon, Sylvie Hauguel ; Amini, Saeid B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-d768eede0c6fb51dc0b6bdff8306f826843238cfc1195281877f59d1914731273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adipose Tissue - anatomy &amp; histology</topic><topic>Adult</topic><topic>age</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Body Composition</topic><topic>Centers for Disease Control and Prevention, U.S</topic><topic>Child</topic><topic>children</topic><topic>Children &amp; youth</topic><topic>Childrens health</topic><topic>Diabetes, Gestational - blood</topic><topic>disease incidence</topic><topic>disease prevention</topic><topic>Feeding. 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Psychology</topic><topic>gestational diabetes</topic><topic>Glucose Intolerance - epidemiology</topic><topic>glucose tolerance</topic><topic>health effects assessments</topic><topic>high energy diet</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>maternal effect</topic><topic>Metabolic Diseases - epidemiology</topic><topic>metabolic syndrome</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Odds Ratio</topic><topic>Perinatal Care - standards</topic><topic>perinatal period</topic><topic>physical activity</topic><topic>prediction</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>United States</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Weight control</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catalano, Patrick M</creatorcontrib><creatorcontrib>Farrell, Kristen</creatorcontrib><creatorcontrib>Thomas, Alicia</creatorcontrib><creatorcontrib>Huston-Presley, Larraine</creatorcontrib><creatorcontrib>Mencin, Patricia</creatorcontrib><creatorcontrib>de Mouzon, Sylvie Hauguel</creatorcontrib><creatorcontrib>Amini, Saeid B</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catalano, Patrick M</au><au>Farrell, Kristen</au><au>Thomas, Alicia</au><au>Huston-Presley, Larraine</au><au>Mencin, Patricia</au><au>de Mouzon, Sylvie Hauguel</au><au>Amini, Saeid B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perinatal risk factors for childhood obesity and metabolic dysregulation</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>90</volume><issue>5</issue><spage>1303</spage><epage>1313</epage><pages>1303-1313</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>BACKGROUND: Childhood obesity has increased significantly in recent decades. OBJECTIVE: The objective was to examine the perinatal risk factors related to childhood obesity. DESIGN: In a prospective study, 89 women with normal glucose tolerance (NGT) or gestational diabetes mellitus (GDM) and their offspring were evaluated at birth and at 8.8 ± 1.8 y. At birth, obstetrical data, parental anthropometric measures, and neonatal body composition were assessed; at follow-up, diet and activity were assessed and laboratory studies were conducted. Weight was classified by using weight for age and sex, and body composition was measured by using dual-energy X-ray absorptiometry. In childhood, data were analyzed as tertiles and prediction models were developed by using logistic and stepwise regression. RESULTS: No significant differences in Centers for Disease Control and Prevention weight percentiles, body composition, and most metabolic measures were observed between children of mothers with NGT and GDM at follow-up. Children in the upper tertile for weight had greater energy intake (P = 0.02), skinfold thickness (P = 0.0001), and leptin concentrations (P &lt; 0.0001) than did those in tertiles 1 and 2. Children in the upper tertile for percentage body fat had greater waist circumference (P = 0.0001), insulin resistance (P = 0.002), and triglyceride (P = 0.009) and leptin (P = 0.0001) concentrations than did children in tertiles 1 and 2. The correlation between body fat at birth and follow-up was r = 0.29 (P = 0.02). The strongest perinatal predictor for a child in the upper tertile for weight was maternal pregravid body mass index (BMI; kg/m²) &gt;30 (odds ratio: 3.75; 95% CI: 1.39, 10.10; P = 0.009) and for percentage body fat was maternal pregravid BMI &gt;30 (odds ratio: 5.45; 95% CI: 1.62, 18.41; P = 0.006). CONCLUSION: Maternal pregravid BMI, independent of maternal glucose status or birth weight, was the strongest predictor of childhood obesity.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>19759171</pmid><doi>10.3945/ajcn.2008.27416</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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subjects Adipose Tissue - anatomy & histology
Adult
age
Biological and medical sciences
Birth weight
Body Composition
Centers for Disease Control and Prevention, U.S
Child
children
Children & youth
Childrens health
Diabetes, Gestational - blood
disease incidence
disease prevention
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
gestational diabetes
Glucose Intolerance - epidemiology
glucose tolerance
health effects assessments
high energy diet
Humans
Infant
Infant, Newborn
Male
maternal effect
Metabolic Diseases - epidemiology
metabolic syndrome
Mothers
Obesity
Obesity - epidemiology
Odds Ratio
Perinatal Care - standards
perinatal period
physical activity
prediction
Pregnancy
Risk Factors
United States
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weight control
Weight Gain - physiology
title Perinatal risk factors for childhood obesity and metabolic dysregulation
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