HLA-DRB1 and -DQB1 loci in three west African ethnic groups: Genetic relationship with sub-Saharan African and European populations
Abstract The Fulani of west Africa have been shown to be less susceptible to malaria and to mount a stronger immune response to malaria than sympatric ethnic groups. The analysis of HLA diversity is useful for the assessment of the genetic distance between the Fulani and sympatric populations, which...
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| Veröffentlicht in: | Human immunology 2009-11, Vol.70 (11), p.903-909 |
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| creator | Lulli, Patrizia Mangano, Valentina D Onori, Annamaria Batini, Chiara Luoni, Gaia Sirima, Bienvenu S Nebie, Issa Chessa, Luciana Petrarca, Vincenzo Modiano, David |
| description | Abstract The Fulani of west Africa have been shown to be less susceptible to malaria and to mount a stronger immune response to malaria than sympatric ethnic groups. The analysis of HLA diversity is useful for the assessment of the genetic distance between the Fulani and sympatric populations, which represents the necessary theoretical background for the investigation of genetic determinants of susceptibility to malaria. We assessed the polymorphism of HLA-DRB1 and - DQB1 loci and analyzed the distribution of alleles/haplotypes in Fulani, Mossi, and Rimaibé from Burkina Faso. We then investigated the genetic relationship of these three ethnic groups with other sub-Saharan African populations as well as with Europeans. We confirmed that the Fulani from Burkina Faso are genetically distinct from sympatric Mossi and Rimaibé. Furthermore the Fulani from Burkina Faso are close to those from The Gambia and, intriguingly, share the distribution of specific alleles with east African populations (Amhara and Oromo). It is noteworthy that the HLA-DRB1*04 and - DQB1*02 alleles, which are implicated in the development of several autoimmune diseases, are present at high frequency in the Fulani, suggesting their potential involvement in the enhanced immune reactivity observed in this population. |
| doi_str_mv | 10.1016/j.humimm.2009.07.025 |
| format | Article |
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The analysis of HLA diversity is useful for the assessment of the genetic distance between the Fulani and sympatric populations, which represents the necessary theoretical background for the investigation of genetic determinants of susceptibility to malaria. We assessed the polymorphism of HLA-DRB1 and - DQB1 loci and analyzed the distribution of alleles/haplotypes in Fulani, Mossi, and Rimaibé from Burkina Faso. We then investigated the genetic relationship of these three ethnic groups with other sub-Saharan African populations as well as with Europeans. We confirmed that the Fulani from Burkina Faso are genetically distinct from sympatric Mossi and Rimaibé. Furthermore the Fulani from Burkina Faso are close to those from The Gambia and, intriguingly, share the distribution of specific alleles with east African populations (Amhara and Oromo). It is noteworthy that the HLA-DRB1*04 and - DQB1*02 alleles, which are implicated in the development of several autoimmune diseases, are present at high frequency in the Fulani, suggesting their potential involvement in the enhanced immune reactivity observed in this population.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2009.07.025</identifier><identifier>PMID: 19664674</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Africa South of the Sahara ; Africa, Western ; Aged ; Allergy and Immunology ; Autoimmunity ; Child ; Europe ; Genetic Loci ; Genetics, Population ; HLA ; HLA-DQ Antigens - genetics ; HLA-DQ Antigens - immunology ; HLA-DQ beta-Chains ; HLA-DR Antigens - genetics ; HLA-DR Antigens - immunology ; HLA-DRB1 Chains ; Humans ; Malaria ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - immunology ; Middle Aged ; west Africa ; Young Adult</subject><ispartof>Human immunology, 2009-11, Vol.70 (11), p.903-909</ispartof><rights>American Society for Histocompatibility and Immunogenetics</rights><rights>2009 American Society for Histocompatibility and Immunogenetics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-d747eab316662c2f3a32010d9d8f368499c700d27f9e52d2244f407e16a9f3a63</citedby><cites>FETCH-LOGICAL-c447t-d747eab316662c2f3a32010d9d8f368499c700d27f9e52d2244f407e16a9f3a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0198885909002006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19664674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lulli, Patrizia</creatorcontrib><creatorcontrib>Mangano, Valentina D</creatorcontrib><creatorcontrib>Onori, Annamaria</creatorcontrib><creatorcontrib>Batini, Chiara</creatorcontrib><creatorcontrib>Luoni, Gaia</creatorcontrib><creatorcontrib>Sirima, Bienvenu S</creatorcontrib><creatorcontrib>Nebie, Issa</creatorcontrib><creatorcontrib>Chessa, Luciana</creatorcontrib><creatorcontrib>Petrarca, Vincenzo</creatorcontrib><creatorcontrib>Modiano, David</creatorcontrib><title>HLA-DRB1 and -DQB1 loci in three west African ethnic groups: Genetic relationship with sub-Saharan African and European populations</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Abstract The Fulani of west Africa have been shown to be less susceptible to malaria and to mount a stronger immune response to malaria than sympatric ethnic groups. The analysis of HLA diversity is useful for the assessment of the genetic distance between the Fulani and sympatric populations, which represents the necessary theoretical background for the investigation of genetic determinants of susceptibility to malaria. We assessed the polymorphism of HLA-DRB1 and - DQB1 loci and analyzed the distribution of alleles/haplotypes in Fulani, Mossi, and Rimaibé from Burkina Faso. We then investigated the genetic relationship of these three ethnic groups with other sub-Saharan African populations as well as with Europeans. We confirmed that the Fulani from Burkina Faso are genetically distinct from sympatric Mossi and Rimaibé. Furthermore the Fulani from Burkina Faso are close to those from The Gambia and, intriguingly, share the distribution of specific alleles with east African populations (Amhara and Oromo). It is noteworthy that the HLA-DRB1*04 and - DQB1*02 alleles, which are implicated in the development of several autoimmune diseases, are present at high frequency in the Fulani, suggesting their potential involvement in the enhanced immune reactivity observed in this population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Africa South of the Sahara</subject><subject>Africa, Western</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Autoimmunity</subject><subject>Child</subject><subject>Europe</subject><subject>Genetic Loci</subject><subject>Genetics, Population</subject><subject>HLA</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ Antigens - immunology</subject><subject>HLA-DQ beta-Chains</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR Antigens - immunology</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Malaria</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Middle Aged</subject><subject>west Africa</subject><subject>Young Adult</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxS0EokvhGyDkE5yyjB3HjjkgLW1pkVZCUDhbXmdCvORf7YSq537xOtpFSBzgZI_0e28084aQlwzWDJh8u183c-e7bs0B9BrUGnjxiKxYqXTGmJSPyQqYLrOyLPQJeRbjHgAUKPGUnDAtpZBKrMj91XaTnX_9wKjtK5qdf0m_dnCe-p5OTUCktxgnuqmDd7anODW9d_RHGOYxvqOX2OOU6oCtnfzQx8aP9NZPDY3zLru2jQ1J9Fu8dLiYwzBiKsZhnI-i5-RJbduIL47vKfn-8eLb2VW2_Xz56WyzzZwQasoqJRTaXZ5mk9zxOrc5BwaVrso6l6XQ2imAiqtaY8ErzoWoBShk0uoEy_yUvDn4jmG4mdNYpvPRYdvaHoc5GpUL0HlRLOTrf5KcMcZzWSRQHEAXhhgD1mYMvrPhzjAwS0xmbw4xmSUmA8qkmJLs1dF_3nVY_REdc0nA-wOAaR-_PAYTncfeYeUDuslUg_9fh78NXOtTdLb9iXcY98Mc-rRrw0zkBsz1cirLpYAGSD4yfwBMoLl7</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Lulli, Patrizia</creator><creator>Mangano, Valentina D</creator><creator>Onori, Annamaria</creator><creator>Batini, Chiara</creator><creator>Luoni, Gaia</creator><creator>Sirima, Bienvenu S</creator><creator>Nebie, Issa</creator><creator>Chessa, Luciana</creator><creator>Petrarca, Vincenzo</creator><creator>Modiano, David</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>HLA-DRB1 and -DQB1 loci in three west African ethnic groups: Genetic relationship with sub-Saharan African and European populations</title><author>Lulli, Patrizia ; Mangano, Valentina D ; Onori, Annamaria ; Batini, Chiara ; Luoni, Gaia ; Sirima, Bienvenu S ; Nebie, Issa ; Chessa, Luciana ; Petrarca, Vincenzo ; Modiano, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-d747eab316662c2f3a32010d9d8f368499c700d27f9e52d2244f407e16a9f3a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Africa South of the Sahara</topic><topic>Africa, Western</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Autoimmunity</topic><topic>Child</topic><topic>Europe</topic><topic>Genetic Loci</topic><topic>Genetics, Population</topic><topic>HLA</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ Antigens - immunology</topic><topic>HLA-DQ beta-Chains</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR Antigens - immunology</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Malaria</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Middle Aged</topic><topic>west Africa</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lulli, Patrizia</creatorcontrib><creatorcontrib>Mangano, Valentina D</creatorcontrib><creatorcontrib>Onori, Annamaria</creatorcontrib><creatorcontrib>Batini, Chiara</creatorcontrib><creatorcontrib>Luoni, Gaia</creatorcontrib><creatorcontrib>Sirima, Bienvenu S</creatorcontrib><creatorcontrib>Nebie, Issa</creatorcontrib><creatorcontrib>Chessa, Luciana</creatorcontrib><creatorcontrib>Petrarca, Vincenzo</creatorcontrib><creatorcontrib>Modiano, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lulli, Patrizia</au><au>Mangano, Valentina D</au><au>Onori, Annamaria</au><au>Batini, Chiara</au><au>Luoni, Gaia</au><au>Sirima, Bienvenu S</au><au>Nebie, Issa</au><au>Chessa, Luciana</au><au>Petrarca, Vincenzo</au><au>Modiano, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-DRB1 and -DQB1 loci in three west African ethnic groups: Genetic relationship with sub-Saharan African and European populations</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>70</volume><issue>11</issue><spage>903</spage><epage>909</epage><pages>903-909</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>Abstract The Fulani of west Africa have been shown to be less susceptible to malaria and to mount a stronger immune response to malaria than sympatric ethnic groups. The analysis of HLA diversity is useful for the assessment of the genetic distance between the Fulani and sympatric populations, which represents the necessary theoretical background for the investigation of genetic determinants of susceptibility to malaria. We assessed the polymorphism of HLA-DRB1 and - DQB1 loci and analyzed the distribution of alleles/haplotypes in Fulani, Mossi, and Rimaibé from Burkina Faso. We then investigated the genetic relationship of these three ethnic groups with other sub-Saharan African populations as well as with Europeans. We confirmed that the Fulani from Burkina Faso are genetically distinct from sympatric Mossi and Rimaibé. Furthermore the Fulani from Burkina Faso are close to those from The Gambia and, intriguingly, share the distribution of specific alleles with east African populations (Amhara and Oromo). It is noteworthy that the HLA-DRB1*04 and - DQB1*02 alleles, which are implicated in the development of several autoimmune diseases, are present at high frequency in the Fulani, suggesting their potential involvement in the enhanced immune reactivity observed in this population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19664674</pmid><doi>10.1016/j.humimm.2009.07.025</doi><tpages>7</tpages></addata></record> |
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| ispartof | Human immunology, 2009-11, Vol.70 (11), p.903-909 |
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| subjects | Adolescent Adult Africa South of the Sahara Africa, Western Aged Allergy and Immunology Autoimmunity Child Europe Genetic Loci Genetics, Population HLA HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology HLA-DQ beta-Chains HLA-DR Antigens - genetics HLA-DR Antigens - immunology HLA-DRB1 Chains Humans Malaria Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Middle Aged west Africa Young Adult |
| title | HLA-DRB1 and -DQB1 loci in three west African ethnic groups: Genetic relationship with sub-Saharan African and European populations |
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