Treatment of recurrent aphthous stomatitis with clofazimine
Objective The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis. Study design In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three pa...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2009-11, Vol.108 (5), p.714-721 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | de Abreu, Marilda Aparecida Milanez Morgado, MD, MS Hirata, Cleonice Hitomi Watashi, MD, PhD Pimentel, Dalva Regina Neto, MD, MS Weckx, Luc Louis Maurice, MD, PhD |
| description | Objective The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis. Study design In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms. Results A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with ≤6% in the other groups). A significantly greater percentage of treatment interruption occurred in the colchicine group because of gastrointestinal effects (23%-45%). Individuals in the clofazimine group who continued to suffer from aphthous stomatitis presented with better results for the evaluated variables. Conclusion Clofazimine should be considered for the treatment of recurrent aphthous stomatitis. |
| doi_str_mv | 10.1016/j.tripleo.2009.05.009 |
| format | Article |
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Study design In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms. Results A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with ≤6% in the other groups). A significantly greater percentage of treatment interruption occurred in the colchicine group because of gastrointestinal effects (23%-45%). Individuals in the clofazimine group who continued to suffer from aphthous stomatitis presented with better results for the evaluated variables. Conclusion Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2009.05.009</identifier><identifier>PMID: 19699111</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Clofazimine - therapeutic use ; Colchicine - therapeutic use ; Dentistry ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Pain Measurement ; Pharmacology. Drug treatments ; Single-Blind Method ; Stomatitis, Aphthous - drug therapy ; Surgery ; Young Adult</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2009-11, Vol.108 (5), p.714-721</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-7bbddfd67576ba1beb8780a7b56caf39f6cef113bce6e92b967098dd04ad2e573</citedby><cites>FETCH-LOGICAL-c449t-7bbddfd67576ba1beb8780a7b56caf39f6cef113bce6e92b967098dd04ad2e573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1079210409002960$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22093228$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19699111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Abreu, Marilda Aparecida Milanez Morgado, MD, MS</creatorcontrib><creatorcontrib>Hirata, Cleonice Hitomi Watashi, MD, PhD</creatorcontrib><creatorcontrib>Pimentel, Dalva Regina Neto, MD, MS</creatorcontrib><creatorcontrib>Weckx, Luc Louis Maurice, MD, PhD</creatorcontrib><title>Treatment of recurrent aphthous stomatitis with clofazimine</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis. Study design In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms. Results A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with ≤6% in the other groups). A significantly greater percentage of treatment interruption occurred in the colchicine group because of gastrointestinal effects (23%-45%). Individuals in the clofazimine group who continued to suffer from aphthous stomatitis presented with better results for the evaluated variables. Conclusion Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Clofazimine - therapeutic use</subject><subject>Colchicine - therapeutic use</subject><subject>Dentistry</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pain Measurement</subject><subject>Pharmacology. Drug treatments</subject><subject>Single-Blind Method</subject><subject>Stomatitis, Aphthous - drug therapy</subject><subject>Surgery</subject><subject>Young Adult</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2L1TAQhoso7pc_QemNeNU6SdukQXCRZf2Ahb3YFbwLaTLh5Ng2xyRVdn-9KacoeOPVJPDMO8MzRfGSQE2AsLf7OgV3GNHXFEDU0NW5PClOSUf7qhHdt6f5DVxUlEB7UpzFuAcA1gjxvDghgglBCDkt3t0HVGnCOZXelgH1EsL6UYdd2vklljH5SSWXXCx_ubQr9eitenSTm_GieGbVGPHFVs-Lrx-v768-Vze3n75cfbipdNuKVPFhMMYaxjvOBkUGHHreg-JDx7SyjbBMoyWkGTQyFHQQjIPojYFWGYodb86LN8fcQ_A_FoxJTi5qHEc1Y15R8qYFQXjLMtkdSR18jAGtPAQ3qfAgCchVm9zLTZtctUnoZC6579U2YRkmNH-7Nk8ZeL0BKmo12qBm7eIfjtIcQmmfucsjh9nHT4dBRu1w1mhcdpuk8e6_q7z_J0GPbnZ56Hd8wLj3S5izbElkpBLk3Xrj9cQgAKhg0PwGj4GkcQ</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>de Abreu, Marilda Aparecida Milanez Morgado, MD, MS</creator><creator>Hirata, Cleonice Hitomi Watashi, MD, PhD</creator><creator>Pimentel, Dalva Regina Neto, MD, MS</creator><creator>Weckx, Luc Louis Maurice, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Treatment of recurrent aphthous stomatitis with clofazimine</title><author>de Abreu, Marilda Aparecida Milanez Morgado, MD, MS ; Hirata, Cleonice Hitomi Watashi, MD, PhD ; Pimentel, Dalva Regina Neto, MD, MS ; Weckx, Luc Louis Maurice, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-7bbddfd67576ba1beb8780a7b56caf39f6cef113bce6e92b967098dd04ad2e573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Clofazimine - therapeutic use</topic><topic>Colchicine - therapeutic use</topic><topic>Dentistry</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pain Measurement</topic><topic>Pharmacology. Drug treatments</topic><topic>Single-Blind Method</topic><topic>Stomatitis, Aphthous - drug therapy</topic><topic>Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Abreu, Marilda Aparecida Milanez Morgado, MD, MS</creatorcontrib><creatorcontrib>Hirata, Cleonice Hitomi Watashi, MD, PhD</creatorcontrib><creatorcontrib>Pimentel, Dalva Regina Neto, MD, MS</creatorcontrib><creatorcontrib>Weckx, Luc Louis Maurice, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Abreu, Marilda Aparecida Milanez Morgado, MD, MS</au><au>Hirata, Cleonice Hitomi Watashi, MD, PhD</au><au>Pimentel, Dalva Regina Neto, MD, MS</au><au>Weckx, Luc Louis Maurice, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of recurrent aphthous stomatitis with clofazimine</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>108</volume><issue>5</issue><spage>714</spage><epage>721</epage><pages>714-721</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis. Study design In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms. Results A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with ≤6% in the other groups). A significantly greater percentage of treatment interruption occurred in the colchicine group because of gastrointestinal effects (23%-45%). Individuals in the clofazimine group who continued to suffer from aphthous stomatitis presented with better results for the evaluated variables. Conclusion Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19699111</pmid><doi>10.1016/j.tripleo.2009.05.009</doi><tpages>8</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2009-11, Vol.108 (5), p.714-721 |
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| subjects | Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clofazimine - therapeutic use Colchicine - therapeutic use Dentistry Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Humans Male Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Pain Measurement Pharmacology. Drug treatments Single-Blind Method Stomatitis, Aphthous - drug therapy Surgery Young Adult |
| title | Treatment of recurrent aphthous stomatitis with clofazimine |
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