Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia

Background: Altered glutamate transmission has been found in the medial temporal lobe in severe psychiatric illnesses, including major depressive disorder (MDD) and bipolar disorder (BD). The vesicular glutamate transporters (VGLUTs) have a pivotal role in presynaptic release of glutamate into the...

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Veröffentlicht in:	Bipolar disorders 2009-11, Vol.11 (7), p.711-725
Hauptverfasser:	Uezato, Akihito, Meador-Woodruff, James H, McCullumsmith, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis of Variance Animals Antidepressive Agents, Tricyclic - pharmacology Antipsychotic Agents - pharmacology Bipolar Disorder - pathology Clozapine - pharmacology Depressive Disorder, Major - pathology entorhinal cortex Female Gene Expression Regulation - drug effects Haloperidol - pharmacology hippocampus Hippocampus - drug effects Hippocampus - metabolism Humans Imipramine - pharmacology in situ hybridization inferior temporal gyrus Male Middle Aged middle temporal gyrus mood disorders Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Schizophrenia - pathology Statistics as Topic Temporal Lobe - metabolism Vesicular Glutamate Transport Proteins - classification Vesicular Glutamate Transport Proteins - genetics Vesicular Glutamate Transport Proteins - metabolism VGLUT
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