Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity

Abstract Aim : We have reported the in vitro and in vivo anticancer activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) derived from a Japanese spice, wasabi. In order to obtain some clues about the mechanism of the anticancer activity, we have studied the effect of alkyl isothiocyanates (...

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Veröffentlicht in:	Cancer epidemiology 2009-10, Vol.33 (3), p.288-292
Hauptverfasser:	Nomura, Takahiro, Uehara, Yoshimasa, Kawajiri, Hiroo, Ryoyama, Kazuo, Yamori, Takao, Fuke, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl isothiocyanates Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer Carcinoma, Squamous Cell - metabolism Cell Line, Tumor Cellular biology Dose-Response Relationship, Drug EGF receptor Electrophoresis, Polyacrylamide Gel Enzymes Epidemiology Epidermal growth factor Food component Hematology, Oncology and Palliative Medicine Humans Hydroquinones - pharmacology Internal Medicine Isothiocyanates - administration & dosage Isothiocyanates - chemistry Isothiocyanates - pharmacology K562 Cells Kinase Kinases Phosphorylation - drug effects Protein-Tyrosine Kinases - drug effects Protein-Tyrosine Kinases - metabolism Proteins Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - metabolism Wasabi
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