Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients

Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardio...

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Veröffentlicht in:Journal of human hypertension 2009-11, Vol.23 (11), p.743-750
Hauptverfasser: Milan, A, Caserta, M A, Dematteis, A, Naso, D, Pertusio, A, Magnino, C, Puglisi, E, Rabbia, F, Pandian, N G, Mulatero, P, Veglio, F
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container_end_page 750
container_issue 11
container_start_page 743
container_title Journal of human hypertension
container_volume 23
creator Milan, A
Caserta, M A
Dematteis, A
Naso, D
Pertusio, A
Magnino, C
Puglisi, E
Rabbia, F
Pandian, N G
Mulatero, P
Veglio, F
description Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged (
doi_str_mv 10.1038/jhh.2009.15
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Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged (&lt;70 years old) essential hypertensive patients.We evaluated cardiac structure and function in 458 patients, 394 treated and untreated mild to moderate essential hypertensives patients (mean±s.d. age 48.4±11.1 years) with no associated clinical condition and 64 normotensive control participants (age 45.7±12.8 years; P =0.12). A multivariate analysis was performed to calculate the relative weight of each of the variables considered able to predict LAV. The LAV index (LAVi) was significantly increased in the essential hypertensive group vs the control group and was significantly dependent on blood pressure levels (SBP and DBP, P &lt;0.05 for both) and body mass index (BMI) ( P &lt;0.0001). Considering the left ventricular (LV) variables, the LV mass index (LVMI) ( R 2 =0.19, P &lt;0.001) and LAV were increased in essential hypertensive patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV showed lower systolic and diastolic function and an increased LVMI. The LAVi is dependent on blood pressure levels and anthropometric variables (age and BMI). Further structural (LVMI) and functional (systolic and diastolic) variables are related to the LAVi; LVMI is the most important variable associated with LAV in mild to moderate essential hypertensive adult patients. These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2009.15</identifier><identifier>PMID: 19262581</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Age ; Age Factors ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Atrial Fibrillation - diagnostic imaging ; Atrial Fibrillation - etiology ; Atrial Fibrillation - physiopathology ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Body Mass Index ; Cardiology. Vascular system ; Case-Control Studies ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Complications and side effects ; Control ; Diagnosis ; Drug therapy ; Echocardiography, Doppler ; Epidemiology ; Fibrillation ; Health Administration ; Heart ; Heart Atria - diagnostic imaging ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - diagnostic imaging ; Hypertension - drug therapy ; Hypertension - physiopathology ; Hypertrophy ; Hypertrophy, Left Ventricular - etiology ; Hypertrophy, Left Ventricular - physiopathology ; Linear Models ; Measurement ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Morbidity ; Multivariate analysis ; original-article ; Patients ; Predictive Value of Tests ; Public Health ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Structure-function relationships ; Variables ; Ventricle ; Ventricular Function, Left</subject><ispartof>Journal of human hypertension, 2009-11, Vol.23 (11), p.743-750</ispartof><rights>Macmillan Publishers Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2009</rights><rights>Macmillan Publishers Limited 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-51f536a8c4f49756ceebeb14a9f915d9b1e3bc9d225629ec65098da185101ac73</citedby><cites>FETCH-LOGICAL-c508t-51f536a8c4f49756ceebeb14a9f915d9b1e3bc9d225629ec65098da185101ac73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhh.2009.15$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhh.2009.15$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=21998178$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19262581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Milan, A</creatorcontrib><creatorcontrib>Caserta, M A</creatorcontrib><creatorcontrib>Dematteis, A</creatorcontrib><creatorcontrib>Naso, D</creatorcontrib><creatorcontrib>Pertusio, A</creatorcontrib><creatorcontrib>Magnino, C</creatorcontrib><creatorcontrib>Puglisi, E</creatorcontrib><creatorcontrib>Rabbia, F</creatorcontrib><creatorcontrib>Pandian, N G</creatorcontrib><creatorcontrib>Mulatero, P</creatorcontrib><creatorcontrib>Veglio, F</creatorcontrib><title>Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged (&lt;70 years old) essential hypertensive patients.We evaluated cardiac structure and function in 458 patients, 394 treated and untreated mild to moderate essential hypertensives patients (mean±s.d. age 48.4±11.1 years) with no associated clinical condition and 64 normotensive control participants (age 45.7±12.8 years; P =0.12). A multivariate analysis was performed to calculate the relative weight of each of the variables considered able to predict LAV. The LAV index (LAVi) was significantly increased in the essential hypertensive group vs the control group and was significantly dependent on blood pressure levels (SBP and DBP, P &lt;0.05 for both) and body mass index (BMI) ( P &lt;0.0001). Considering the left ventricular (LV) variables, the LV mass index (LVMI) ( R 2 =0.19, P &lt;0.001) and LAV were increased in essential hypertensive patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV showed lower systolic and diastolic function and an increased LVMI. The LAVi is dependent on blood pressure levels and anthropometric variables (age and BMI). Further structural (LVMI) and functional (systolic and diastolic) variables are related to the LAVi; LVMI is the most important variable associated with LAV in mild to moderate essential hypertensive adult patients. These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Atrial Fibrillation - diagnostic imaging</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Complications and side effects</subject><subject>Control</subject><subject>Diagnosis</subject><subject>Drug therapy</subject><subject>Echocardiography, Doppler</subject><subject>Epidemiology</subject><subject>Fibrillation</subject><subject>Health Administration</subject><subject>Heart</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Linear Models</subject><subject>Measurement</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Multivariate analysis</subject><subject>original-article</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Public Health</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Structure-function relationships</subject><subject>Variables</subject><subject>Ventricle</subject><subject>Ventricular Function, Left</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhiMEokvhxB1ZVJQD3cVOYic-lqp8SJW4wNmadSaNV4692M6i_gV-NY52xVJU5MNInued8YzfonjJ6IrRqn2_GYZVSalcMf6oWLC6EUvOy-ZxsaCS06Usa3pSPItxQ-mcbJ8WJ0yWouQtWxS_PljvO7INGOMUkFjcoY0XOfaJ7NClYPRkIZARYiTgOtJPTifjHYGMax8CWkjYkZ8mDXsZZBFYsvN2GpEYR0ZjO5I8GX2HIcNkuNtiSOii2SHZQjK5UXxePOnBRnxxiKfF94_X364-L2--fvpydXmz1Jy2aclZzysBra77WjZcaMQ1rlkNspeMd3LNsFpr2ZUlF6VELTiVbQes5Ywy0E11Wrzd190G_2PCmNRookZrwaGfomqqmra85m0mz_4hN34KLj9OlaKmggvGeaZe_5diUgrR0OpY6hYsKuN6nwLoubG6LBnlkgkpM7V6gMqnw9Fo77A3-f6e4PwvwYBg0xDz3ucPivfBd3tQBx9jwF5tgxkh3ClG1WwjlW2kZhspNo_06jDStB6xO7IH32TgzQGAqMH2AZw28Q83z92yZt7gxZ6LOeVuMRx381Df31PZ3XQ</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Milan, A</creator><creator>Caserta, M A</creator><creator>Dematteis, A</creator><creator>Naso, D</creator><creator>Pertusio, A</creator><creator>Magnino, C</creator><creator>Puglisi, E</creator><creator>Rabbia, F</creator><creator>Pandian, N G</creator><creator>Mulatero, P</creator><creator>Veglio, F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients</title><author>Milan, A ; Caserta, M A ; Dematteis, A ; Naso, D ; Pertusio, A ; Magnino, C ; Puglisi, E ; Rabbia, F ; Pandian, N G ; Mulatero, P ; Veglio, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-51f536a8c4f49756ceebeb14a9f915d9b1e3bc9d225629ec65098da185101ac73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Atrial Fibrillation - diagnostic imaging</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. 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source MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals
subjects Adult
Age
Age Factors
Antihypertensive Agents - therapeutic use
Arterial hypertension. Arterial hypotension
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Mass Index
Cardiology. Vascular system
Case-Control Studies
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Complications and side effects
Control
Diagnosis
Drug therapy
Echocardiography, Doppler
Epidemiology
Fibrillation
Health Administration
Heart
Heart Atria - diagnostic imaging
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Hypertension
Hypertension - complications
Hypertension - diagnostic imaging
Hypertension - drug therapy
Hypertension - physiopathology
Hypertrophy
Hypertrophy, Left Ventricular - etiology
Hypertrophy, Left Ventricular - physiopathology
Linear Models
Measurement
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Morbidity
Multivariate analysis
original-article
Patients
Predictive Value of Tests
Public Health
Risk Assessment
Risk Factors
Severity of Illness Index
Structure-function relationships
Variables
Ventricle
Ventricular Function, Left
title Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients
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