Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients
Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardio...
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description | Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged ( |
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P
=0.12). A multivariate analysis was performed to calculate the relative weight of each of the variables considered able to predict LAV. The LAV index (LAVi) was significantly increased in the essential hypertensive group vs the control group and was significantly dependent on blood pressure levels (SBP and DBP,
P
<0.05 for both) and body mass index (BMI) (
P
<0.0001). Considering the left ventricular (LV) variables, the LV mass index (LVMI) (
R
2
=0.19,
P
<0.001) and LAV were increased in essential hypertensive patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV showed lower systolic and diastolic function and an increased LVMI. The LAVi is dependent on blood pressure levels and anthropometric variables (age and BMI). Further structural (LVMI) and functional (systolic and diastolic) variables are related to the LAVi; LVMI is the most important variable associated with LAV in mild to moderate essential hypertensive adult patients. These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2009.15</identifier><identifier>PMID: 19262581</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Age ; Age Factors ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Atrial Fibrillation - diagnostic imaging ; Atrial Fibrillation - etiology ; Atrial Fibrillation - physiopathology ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Body Mass Index ; Cardiology. Vascular system ; Case-Control Studies ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Complications and side effects ; Control ; Diagnosis ; Drug therapy ; Echocardiography, Doppler ; Epidemiology ; Fibrillation ; Health Administration ; Heart ; Heart Atria - diagnostic imaging ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - diagnostic imaging ; Hypertension - drug therapy ; Hypertension - physiopathology ; Hypertrophy ; Hypertrophy, Left Ventricular - etiology ; Hypertrophy, Left Ventricular - physiopathology ; Linear Models ; Measurement ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Morbidity ; Multivariate analysis ; original-article ; Patients ; Predictive Value of Tests ; Public Health ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Structure-function relationships ; Variables ; Ventricle ; Ventricular Function, Left</subject><ispartof>Journal of human hypertension, 2009-11, Vol.23 (11), p.743-750</ispartof><rights>Macmillan Publishers Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2009</rights><rights>Macmillan Publishers Limited 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-51f536a8c4f49756ceebeb14a9f915d9b1e3bc9d225629ec65098da185101ac73</citedby><cites>FETCH-LOGICAL-c508t-51f536a8c4f49756ceebeb14a9f915d9b1e3bc9d225629ec65098da185101ac73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhh.2009.15$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhh.2009.15$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21998178$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19262581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Milan, A</creatorcontrib><creatorcontrib>Caserta, M A</creatorcontrib><creatorcontrib>Dematteis, A</creatorcontrib><creatorcontrib>Naso, D</creatorcontrib><creatorcontrib>Pertusio, A</creatorcontrib><creatorcontrib>Magnino, C</creatorcontrib><creatorcontrib>Puglisi, E</creatorcontrib><creatorcontrib>Rabbia, F</creatorcontrib><creatorcontrib>Pandian, N G</creatorcontrib><creatorcontrib>Mulatero, P</creatorcontrib><creatorcontrib>Veglio, F</creatorcontrib><title>Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged (<70 years old) essential hypertensive patients.We evaluated cardiac structure and function in 458 patients, 394 treated and untreated mild to moderate essential hypertensives patients (mean±s.d. age 48.4±11.1 years) with no associated clinical condition and 64 normotensive control participants (age 45.7±12.8 years;
P
=0.12). A multivariate analysis was performed to calculate the relative weight of each of the variables considered able to predict LAV. The LAV index (LAVi) was significantly increased in the essential hypertensive group vs the control group and was significantly dependent on blood pressure levels (SBP and DBP,
P
<0.05 for both) and body mass index (BMI) (
P
<0.0001). Considering the left ventricular (LV) variables, the LV mass index (LVMI) (
R
2
=0.19,
P
<0.001) and LAV were increased in essential hypertensive patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV showed lower systolic and diastolic function and an increased LVMI. The LAVi is dependent on blood pressure levels and anthropometric variables (age and BMI). Further structural (LVMI) and functional (systolic and diastolic) variables are related to the LAVi; LVMI is the most important variable associated with LAV in mild to moderate essential hypertensive adult patients. These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Atrial Fibrillation - diagnostic imaging</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Complications and side effects</subject><subject>Control</subject><subject>Diagnosis</subject><subject>Drug therapy</subject><subject>Echocardiography, Doppler</subject><subject>Epidemiology</subject><subject>Fibrillation</subject><subject>Health Administration</subject><subject>Heart</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Linear Models</subject><subject>Measurement</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Multivariate analysis</subject><subject>original-article</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Public Health</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Structure-function relationships</subject><subject>Variables</subject><subject>Ventricle</subject><subject>Ventricular Function, Left</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhiMEokvhxB1ZVJQD3cVOYic-lqp8SJW4wNmadSaNV4692M6i_gV-NY52xVJU5MNInued8YzfonjJ6IrRqn2_GYZVSalcMf6oWLC6EUvOy-ZxsaCS06Usa3pSPItxQ-mcbJ8WJ0yWouQtWxS_PljvO7INGOMUkFjcoY0XOfaJ7NClYPRkIZARYiTgOtJPTifjHYGMax8CWkjYkZ8mDXsZZBFYsvN2GpEYR0ZjO5I8GX2HIcNkuNtiSOii2SHZQjK5UXxePOnBRnxxiKfF94_X364-L2--fvpydXmz1Jy2aclZzysBra77WjZcaMQ1rlkNspeMd3LNsFpr2ZUlF6VELTiVbQes5Ywy0E11Wrzd190G_2PCmNRookZrwaGfomqqmra85m0mz_4hN34KLj9OlaKmggvGeaZe_5diUgrR0OpY6hYsKuN6nwLoubG6LBnlkgkpM7V6gMqnw9Fo77A3-f6e4PwvwYBg0xDz3ucPivfBd3tQBx9jwF5tgxkh3ClG1WwjlW2kZhspNo_06jDStB6xO7IH32TgzQGAqMH2AZw28Q83z92yZt7gxZ6LOeVuMRx381Df31PZ3XQ</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Milan, A</creator><creator>Caserta, M A</creator><creator>Dematteis, A</creator><creator>Naso, D</creator><creator>Pertusio, A</creator><creator>Magnino, C</creator><creator>Puglisi, E</creator><creator>Rabbia, F</creator><creator>Pandian, N G</creator><creator>Mulatero, P</creator><creator>Veglio, F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients</title><author>Milan, A ; Caserta, M A ; Dematteis, A ; Naso, D ; Pertusio, A ; Magnino, C ; Puglisi, E ; Rabbia, F ; Pandian, N G ; Mulatero, P ; Veglio, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-51f536a8c4f49756ceebeb14a9f915d9b1e3bc9d225629ec65098da185101ac73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Atrial Fibrillation - diagnostic imaging</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Complications and side effects</topic><topic>Control</topic><topic>Diagnosis</topic><topic>Drug therapy</topic><topic>Echocardiography, Doppler</topic><topic>Epidemiology</topic><topic>Fibrillation</topic><topic>Health Administration</topic><topic>Heart</topic><topic>Heart Atria - diagnostic imaging</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - diagnostic imaging</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Linear Models</topic><topic>Measurement</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Multivariate analysis</topic><topic>original-article</topic><topic>Patients</topic><topic>Predictive Value of Tests</topic><topic>Public Health</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Structure-function relationships</topic><topic>Variables</topic><topic>Ventricle</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Milan, A</creatorcontrib><creatorcontrib>Caserta, M A</creatorcontrib><creatorcontrib>Dematteis, A</creatorcontrib><creatorcontrib>Naso, D</creatorcontrib><creatorcontrib>Pertusio, A</creatorcontrib><creatorcontrib>Magnino, C</creatorcontrib><creatorcontrib>Puglisi, E</creatorcontrib><creatorcontrib>Rabbia, F</creatorcontrib><creatorcontrib>Pandian, N G</creatorcontrib><creatorcontrib>Mulatero, P</creatorcontrib><creatorcontrib>Veglio, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milan, A</au><au>Caserta, M A</au><au>Dematteis, A</au><au>Naso, D</au><au>Pertusio, A</au><au>Magnino, C</au><au>Puglisi, E</au><au>Rabbia, F</au><au>Pandian, N G</au><au>Mulatero, P</au><au>Veglio, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>23</volume><issue>11</issue><spage>743</spage><epage>750</epage><pages>743-750</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged (<70 years old) essential hypertensive patients.We evaluated cardiac structure and function in 458 patients, 394 treated and untreated mild to moderate essential hypertensives patients (mean±s.d. age 48.4±11.1 years) with no associated clinical condition and 64 normotensive control participants (age 45.7±12.8 years;
P
=0.12). A multivariate analysis was performed to calculate the relative weight of each of the variables considered able to predict LAV. The LAV index (LAVi) was significantly increased in the essential hypertensive group vs the control group and was significantly dependent on blood pressure levels (SBP and DBP,
P
<0.05 for both) and body mass index (BMI) (
P
<0.0001). Considering the left ventricular (LV) variables, the LV mass index (LVMI) (
R
2
=0.19,
P
<0.001) and LAV were increased in essential hypertensive patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV showed lower systolic and diastolic function and an increased LVMI. The LAVi is dependent on blood pressure levels and anthropometric variables (age and BMI). Further structural (LVMI) and functional (systolic and diastolic) variables are related to the LAVi; LVMI is the most important variable associated with LAV in mild to moderate essential hypertensive adult patients. These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19262581</pmid><doi>10.1038/jhh.2009.15</doi><tpages>8</tpages></addata></record> |
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subjects | Adult Age Age Factors Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Atrial Fibrillation - diagnostic imaging Atrial Fibrillation - etiology Atrial Fibrillation - physiopathology Biological and medical sciences Blood and lymphatic vessels Blood Pressure Body Mass Index Cardiology. Vascular system Case-Control Studies Clinical manifestations. Epidemiology. Investigative techniques. Etiology Complications and side effects Control Diagnosis Drug therapy Echocardiography, Doppler Epidemiology Fibrillation Health Administration Heart Heart Atria - diagnostic imaging Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Hypertension Hypertension - complications Hypertension - diagnostic imaging Hypertension - drug therapy Hypertension - physiopathology Hypertrophy Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - physiopathology Linear Models Measurement Medical sciences Medicine Medicine & Public Health Middle Aged Morbidity Multivariate analysis original-article Patients Predictive Value of Tests Public Health Risk Assessment Risk Factors Severity of Illness Index Structure-function relationships Variables Ventricle Ventricular Function, Left |
title | Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients |
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