The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens
When antigen-presenting cells (APCs) encounter inflammatory stimuli, they up-regulate their expression of B7. A small amount of B7 is also constitutively expressed on resting APCs, but its function is unclear. Here we show that initiation of T cell responses requires the expression of B7 on immunizi...
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| Veröffentlicht in: | Nature immunology 2003-07, Vol.4 (7), p.664-669 |
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| creator | Abbas, Abul K Lohr, Jens Knoechel, Birgit Jiang, Shuwei Sharpe, Arlene H |
| description | When antigen-presenting cells (APCs) encounter inflammatory stimuli, they up-regulate their expression of B7. A small amount of B7 is also constitutively expressed on resting APCs, but its function is unclear. Here we show that initiation of T cell responses requires the expression of B7 on immunizing APCs, but the responses are much greater in the absence of basal B7 expression. Transfer of antigen-specific CD4
+
CD25
+
cells reverses the increased responsiveness, and tolerance to a self-protein is broken by immunization in the absence of basal B7, thereby inducing autoimmunity. Similar loss of self-tolerance is seen on depletion of CD25
+
cells. Thus, constitutively expressed B7 costimulators function to suppress T cell activation and maintain self-tolerance, principally by sustaining a population of regulatory T cells. |
| doi_str_mv | 10.1038/ni939 |
| format | Article |
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+
CD25
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+
CD25
+
cells reverses the increased responsiveness, and tolerance to a self-protein is broken by immunization in the absence of basal B7, thereby inducing autoimmunity. Similar loss of self-tolerance is seen on depletion of CD25
+
cells. Thus, constitutively expressed B7 costimulators function to suppress T cell activation and maintain self-tolerance, principally by sustaining a population of regulatory T cells.</description><subject>Abatacept</subject><subject>Animals</subject><subject>Antigens, CD</subject><subject>Antigens, Differentiation - physiology</subject><subject>Autoantigens - immunology</subject><subject>Autoimmunity</subject><subject>B7-1 Antigen - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CTLA-4 Antigen</subject><subject>Female</subject><subject>Immunization</subject><subject>Immunoconjugates</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Ovalbumin - immunology</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkdFr1TAUxoMobl73FwgSBAc-dCZp2iSPc0wdDAS9vgkhTU-7jDa5Jim4_97MXnbZXiSBhPP9zsc5fAidUHJGSS0_eqdq9Qwd04apiinaPn_4E3mEXqV0SwjlouUv0RFlom3LPUa_tjeAnb9xncsh3uFh8Ta74HEY8CeBbUjZzctkipgKh7fYwjThCGkXfIKEc8BDiOBGj43vcYJpqIzPbgSfXqMXg5kSnOzfDfr5-XJ78bW6_vbl6uL8urJc0Vwxwdum66lVLemlZNw0qietYILUVlKuOq5q26m-HQAIY1xaQQBaAX1XyrLeoNPVdxfD7wVS1rNL93MaD2FJWtScCFWT_4JUSiIb2hTw3RPwNizRlyU0Y4QKJctIG3S2QqOZQDs_hByNLaeH2dngYXClfl5MiysXojR8eNRQmAx_8miWlPTVj--P2fcra2NIKcKgd9HNJt5pSvR94vpf4oV7u5906WboD9Q-4sPOqUh-hHhY5anTmxX0Ji8RHpxW9S8Dc7oo</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Abbas, Abul K</creator><creator>Lohr, Jens</creator><creator>Knoechel, Birgit</creator><creator>Jiang, Shuwei</creator><creator>Sharpe, Arlene H</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens</title><author>Abbas, Abul K ; Lohr, Jens ; Knoechel, Birgit ; Jiang, Shuwei ; Sharpe, Arlene H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-27465bd1c960d8824a59d0672703c8149b493cb9d6fee02248c70ee67edbcb983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Abatacept</topic><topic>Animals</topic><topic>Antigens, CD</topic><topic>Antigens, Differentiation - physiology</topic><topic>Autoantigens - immunology</topic><topic>Autoimmunity</topic><topic>B7-1 Antigen - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CTLA-4 Antigen</topic><topic>Female</topic><topic>Immunization</topic><topic>Immunoconjugates</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Ovalbumin - immunology</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbas, Abul K</creatorcontrib><creatorcontrib>Lohr, Jens</creatorcontrib><creatorcontrib>Knoechel, Birgit</creatorcontrib><creatorcontrib>Jiang, Shuwei</creatorcontrib><creatorcontrib>Sharpe, Arlene H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbas, Abul K</au><au>Lohr, Jens</au><au>Knoechel, Birgit</au><au>Jiang, Shuwei</au><au>Sharpe, Arlene H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>4</volume><issue>7</issue><spage>664</spage><epage>669</epage><pages>664-669</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>When antigen-presenting cells (APCs) encounter inflammatory stimuli, they up-regulate their expression of B7. A small amount of B7 is also constitutively expressed on resting APCs, but its function is unclear. Here we show that initiation of T cell responses requires the expression of B7 on immunizing APCs, but the responses are much greater in the absence of basal B7 expression. Transfer of antigen-specific CD4
+
CD25
+
cells reverses the increased responsiveness, and tolerance to a self-protein is broken by immunization in the absence of basal B7, thereby inducing autoimmunity. Similar loss of self-tolerance is seen on depletion of CD25
+
cells. Thus, constitutively expressed B7 costimulators function to suppress T cell activation and maintain self-tolerance, principally by sustaining a population of regulatory T cells.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>12766766</pmid><doi>10.1038/ni939</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Abatacept Animals Antigens, CD Antigens, Differentiation - physiology Autoantigens - immunology Autoimmunity B7-1 Antigen - physiology Biomedical and Life Sciences Biomedicine CTLA-4 Antigen Female Immunization Immunoconjugates Immunology Infectious Diseases Male Mice Mice, Inbred BALB C Ovalbumin - immunology Receptors, Interleukin-2 - analysis T-Lymphocytes - immunology T-Lymphocytes, Helper-Inducer - immunology |
| title | The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens |
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