Antinociceptive properties of caffeic acid derivatives in mice

Ten ester derivatives from caffeic acid were synthesized, and their antinociceptive properties are evaluated in mice. The most active compound, dodecyl ester derivative, exhibited potent and dose-related activity against the writhing test, with a calculated ID 50 value of 15.1 (11.9–19.1) μmol/kg an...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-11, Vol.44 (11), p.4596-4602
Hauptverfasser:	de Campos Buzzi, Fátima, Franzoi, Caroline Liandra, Antonini, Graziele, Fracasso, Mauricio, Filho, Valdir Cechinel, Yunes, Rosendo Augusto, Niero, Rivaldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - chemistry Analgesics - therapeutic use Animals Antinociceptive action Biological and medical sciences Caffeic acid derivatives Caffeic Acids - chemistry Caffeic Acids - therapeutic use Medical sciences Mice Molecular Structure Neuropharmacology Pain - chemically induced Pain - drug therapy Pharmacology. Drug treatments Structure-Activity Relationship
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