New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in stimulated RAW 264.7 murine macrophage

The reaction of 2-acetyl-5,6,7,8-tetrahydronaphthalene 1 with some aldehydes was conducted in the presence of ethyl cyanoacetate and ammonium acetate, yielded the cyanopyridones 2a– c, which react with phosphorous pentasulphide to afford the corresponding thioxopyridine derivatives 3a– c, respective...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-11, Vol.44 (11), p.4547-4556
Hauptverfasser:	Hamdy, Nehal A., Gamal-Eldeen, Amira M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase Animals Anti-inflammatory Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Arachidonate 5-Lipoxygenase - metabolism Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cell Line Cell Proliferation - drug effects Cyclooxygenase 2 - metabolism Cycloxygenase-2 Macrophages - drug effects Medical sciences Mice Phagocytosis - drug effects Pharmacology. Drug treatments Pyrazolopyridine Pyridine Pyridines - chemistry Pyridines - pharmacology Pyridone Pyridones - chemistry Pyridones - pharmacology Reactive Oxygen Species - metabolism Superoxides - metabolism Thioxopyridine
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