ATP Binding Modulates the Nucleic Acid Affinity of Hepatitis C Virus Helicase

The helicase of hepatitis C virus (HCV) unwinds nucleic acid using the energy of ATP hydrolysis. The ATPase cycle is believed to induce protein conformational changes to drive helicase translocation along the length of the nucleic acid. We have investigated the energetics of nucleic acid binding by...

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Veröffentlicht in:	The Journal of biological chemistry 2003-06, Vol.278 (26), p.23311-23316
Hauptverfasser:	Levin, Mikhail K, Gurjar, Madhura M, Patel, Smita S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Allosteric Regulation Binding Sites DNA - metabolism DNA, Single-Stranded - metabolism Hepacivirus - enzymology Kinetics Models, Molecular Molecular Motor Proteins Nucleic Acids - metabolism Protein Conformation RNA - metabolism Spectrometry, Fluorescence Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism
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