Identification of 3-hydroxy-β-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity

Structural comparison of apple constituents with known inducers of phase two cytoprotective enzymes led to the identification of 3-hydroxy-β-damascone and related carotenoid derived aroma compounds as potent inducers of NAD(P)H:quinone reductase (QR) activity. Damascone-related compounds were found...

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Veröffentlicht in:	Molecular nutrition & food research 2009-10, Vol.53 (10), p.1237-1244
Hauptverfasser:	Gerhäuser, Clarissa, Klimo, Karin, Hümmer, Wolfgang, Hölzer, Jana, Petermann, Astrid, Garreta-Rufas, Antonio, Böhmer, Frank-D, Schreier, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anticarcinogenic Agents - pharmacology Apple juice Apples Cancer chemoprevention Carotenoid-derived aroma compounds Cell Line Cell Survival Fruit - chemistry Humans Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Malus - chemistry Metabolic Detoxication, Phase II Mice NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism NAD(P)H:quinone oxidoreductase NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-E2-Related Factor 2 - physiology Nitric Oxide Synthase Type II - metabolism Norisoprenoids - pharmacology Volatile Organic Compounds - pharmacology
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