Pharmacological effects of carvedilol on T-type calcium current in murine HL-1 cells

Carvedilol is widely used in the treatment of cardiovascular diseases including atrial fibrillation. T-type Ca 2+ channels have been recognized recently in the mechanisms underlying atrial arrhythmias. However, it is unclear whether carvedilol may affect the T-type Ca 2+ channel. The present study e...

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Veröffentlicht in:	European journal of pharmacology 2009-10, Vol.621 (1), p.19-25
Hauptverfasser:	Deng, Chunyu, Rao, Fang, Wu, Shulin, Kuang, Sujuan, Liu, Xiaoying, Zhou, Zhiling, Shan, Zhixin, Lin, Qiuxiong, Qian, Weimin, Yang, Min, Geng, Qingshan, Zhang, Youyi, Yu, Xiyong, Lin, Shuguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Calcium Channels, T-Type - metabolism Carbazoles - pharmacology Carvedilol Cell Line Electric Conductivity HL-1 cells Isoquinolines - metabolism Kinetics Medical sciences Mice Patch-Clamp Techniques Pharmacology. Drug treatments Propanolamines - pharmacology Sulfonamides - metabolism T-type Calcium Current ( ICa,T) Whole-cell patch–clamp technique
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