BCG promotes cord blood monocyte-derived dendritic cell maturation with nuclear Rel-B up-regulation and cytosolic IκB α and β degradation

Mycobacterium bovis bacillus Calmette-Guerin (BCG) is given to millions of neonates in developing countries as a vaccine against Mycobacterium tuberculosis; however, little is known about the initiation of response in neonatal dendritic cells (DCs) to BCG. To address this issue, the interaction of B...

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Veröffentlicht in:	Pediatric research 2003-07, Vol.54 (1), p.105-112
Hauptverfasser:	ENMEI LIU, LAW, Helen K. W, LAU, Yu-Lung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies - pharmacology Bacterial Proteins - pharmacology Biological and medical sciences CD4-Positive T-Lymphocytes - metabolism Cell Differentiation Cell Division Cell Nucleus - metabolism Chaperonin 60 Chaperonins - pharmacology Cytosol - metabolism Delivery. Postpartum. Lactation Dendritic Cells - cytology Dendritic Cells - metabolism Down-Regulation Fetal Blood Gynecology. Andrology. Obstetrics Histocompatibility Antigens Class II - metabolism Humans I-kappa B Proteins - metabolism Interferon-gamma - metabolism Interleukin-10 - blood Interleukin-12 - blood Interleukin-4 - metabolism Maternal, fetal and perinatal monitoring Medical sciences Monocytes - cytology Mycobacterium bovis NF-KappaB Inhibitor alpha Protein Subunits - blood Proto-Oncogene Proteins - metabolism Transcription Factor RelB Transcription Factors - metabolism Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Up-Regulation
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