Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of lipid in the aorta, (2) on the level of plasma lipids, and (3) on the number of adherent intimal monocytes and foam cells. Seventy Wistar rats were assigned to one of the following groups: (1) regular diet, (2...

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Veröffentlicht in:	Experimental and molecular pathology 1992-12, Vol.57 (3), p.193-204
Hauptverfasser:	Nunnari, John J., Fisher, Marc, White, Stanley D.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - chemistry Aorta - metabolism Aorta - physiology Biological and medical sciences Blood Pressure - physiology Body Weight - physiology Calcium Channel Blockers - blood Calcium Channel Blockers - pharmacology Cardiovascular system Cell Adhesion - physiology Cell Count Cholesterol - pharmacology Cholic Acids - pharmacology Diet, Atherogenic Diltiazem - analogs & derivatives Diltiazem - blood Diltiazem - pharmacology Heart Rate - physiology Hypercholesterolemia - metabolism Hypercholesterolemia - pathology Hypercholesterolemia - physiopathology Lipid Metabolism Lipids - analysis Lipids - blood Male Medical sciences Miscellaneous Models, Biological Monocytes - cytology Monocytes - physiology Pharmacology. Drug treatments Rats Rats, Wistar Thiouracil - pharmacology
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