Tumor necrosis factor-α in pediatric HIV-1 infection
To evaluate the diagnostic and prognostic value of serum tumor necrosis factor-alpha (TNF-alpha) levels in HIV-1-infected children. Serum levels of TNF-alpha were evaluated in 57 HIV-1-infected symptomatic children aged between 7 months and 8 years. TNF-alpha levels were determined by enzyme immunoa...
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| Veröffentlicht in: | AIDS (London) 1992-11, Vol.6 (11), p.1265-1268 |
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| creator | ELLAURIE, M RUBINSTEIN, A |
| description | To evaluate the diagnostic and prognostic value of serum tumor necrosis factor-alpha (TNF-alpha) levels in HIV-1-infected children.
Serum levels of TNF-alpha were evaluated in 57 HIV-1-infected symptomatic children aged between 7 months and 8 years.
TNF-alpha levels were determined by enzyme immunoassay. The sensitivity of the assay was 10 pg/ml.
TNF-alpha levels (mean +/- s.d.) were significantly elevated in HIV-1-infected patients (285 +/- 390 pg/ml), compared with HIV-1-uninfected age-matched controls (22.7 +/- 4.9 pg/ml). Among HIV-1-infected children the highest levels of TNF-alpha were noted in those with Mycobacterium avium intracellulare (MAI) infection and those with interstitial lymphoid pneumonitis (LIP). In contrast, patients with Pneumocystis carinii pneumonia, progressive encephalopathy or cachexia did not have markedly elevated TNF-alpha levels.
Serum TNF-alpha is increased in symptomatic HIV-1-infected children, with higher levels in children with LIP or MAI. Serum TNF-alpha levels are not diagnostic for cachexia or progressive encephalopathy. |
| doi_str_mv | 10.1097/00002030-199211000-00004 |
| format | Article |
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Serum levels of TNF-alpha were evaluated in 57 HIV-1-infected symptomatic children aged between 7 months and 8 years.
TNF-alpha levels were determined by enzyme immunoassay. The sensitivity of the assay was 10 pg/ml.
TNF-alpha levels (mean +/- s.d.) were significantly elevated in HIV-1-infected patients (285 +/- 390 pg/ml), compared with HIV-1-uninfected age-matched controls (22.7 +/- 4.9 pg/ml). Among HIV-1-infected children the highest levels of TNF-alpha were noted in those with Mycobacterium avium intracellulare (MAI) infection and those with interstitial lymphoid pneumonitis (LIP). In contrast, patients with Pneumocystis carinii pneumonia, progressive encephalopathy or cachexia did not have markedly elevated TNF-alpha levels.
Serum TNF-alpha is increased in symptomatic HIV-1-infected children, with higher levels in children with LIP or MAI. Serum TNF-alpha levels are not diagnostic for cachexia or progressive encephalopathy.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-199211000-00004</identifier><identifier>PMID: 1472332</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>AIDS Dementia Complex - blood ; AIDS Dementia Complex - complications ; AIDS-Related Opportunistic Infections - blood ; AIDS/HIV ; Biological and medical sciences ; Cachexia - blood ; Cachexia - complications ; Child ; Child, Preschool ; HIV Infections - blood ; HIV Infections - complications ; HIV Infections - diagnosis ; HIV-1 ; human immunodeficiency virus 1 ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant ; Medical sciences ; Mycobacterium avium-intracellulare Infection - blood ; Mycobacterium avium-intracellulare Infection - complications ; Pneumonia, Pneumocystis - blood ; Pneumonia, Pneumocystis - complications ; Prognosis ; Pulmonary Fibrosis - blood ; Pulmonary Fibrosis - complications ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>AIDS (London), 1992-11, Vol.6 (11), p.1265-1268</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-f7f01d3dec439fcb3a6adbeac41dc2d4f5880929aabd2ad192cceb668b17823a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4410921$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1472332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ELLAURIE, M</creatorcontrib><creatorcontrib>RUBINSTEIN, A</creatorcontrib><title>Tumor necrosis factor-α in pediatric HIV-1 infection</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To evaluate the diagnostic and prognostic value of serum tumor necrosis factor-alpha (TNF-alpha) levels in HIV-1-infected children.
Serum levels of TNF-alpha were evaluated in 57 HIV-1-infected symptomatic children aged between 7 months and 8 years.
TNF-alpha levels were determined by enzyme immunoassay. The sensitivity of the assay was 10 pg/ml.
TNF-alpha levels (mean +/- s.d.) were significantly elevated in HIV-1-infected patients (285 +/- 390 pg/ml), compared with HIV-1-uninfected age-matched controls (22.7 +/- 4.9 pg/ml). Among HIV-1-infected children the highest levels of TNF-alpha were noted in those with Mycobacterium avium intracellulare (MAI) infection and those with interstitial lymphoid pneumonitis (LIP). In contrast, patients with Pneumocystis carinii pneumonia, progressive encephalopathy or cachexia did not have markedly elevated TNF-alpha levels.
Serum TNF-alpha is increased in symptomatic HIV-1-infected children, with higher levels in children with LIP or MAI. Serum TNF-alpha levels are not diagnostic for cachexia or progressive encephalopathy.</description><subject>AIDS Dementia Complex - blood</subject><subject>AIDS Dementia Complex - complications</subject><subject>AIDS-Related Opportunistic Infections - blood</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cachexia - blood</subject><subject>Cachexia - complications</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - diagnosis</subject><subject>HIV-1</subject><subject>human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Mycobacterium avium-intracellulare Infection - blood</subject><subject>Mycobacterium avium-intracellulare Infection - complications</subject><subject>Pneumonia, Pneumocystis - blood</subject><subject>Pneumonia, Pneumocystis - complications</subject><subject>Prognosis</subject><subject>Pulmonary Fibrosis - blood</subject><subject>Pulmonary Fibrosis - complications</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtOwzAQhi0EKqVwBKQsEDuDx3YSe4kqSitVYlPYRo4fklEexU4WHIuLcCZcWsoSbyz_882M_CGUAbkDIst7kg4ljGCQkgKkF95F_ARNgZcM53kJp2hKaCGxZCU5RxcxviUiJ0JM0CRBlDE6RflmbPuQdVaHPvqYOaWHPuCvz8x32dYar4bgdbZcvWJIkbN68H13ic6caqK9Otwz9LJ43MyXeP38tJo_rLFOOwfsSkfAMGM1Z9LpmqlCmdoqzcFoarjLhSCSSqVqQ5UBSbW2dVGIGkpBmWIzdLufuw39-2jjULU-ats0qrP9GKuScVIIIf4FoeA0T5oSKPbg7r8xWFdtg29V-KiAVDu11a_a6qj2J-Kp9fqwY6xba_4a9y5T_eZQV1GrxgXVaR-PGOdpPAX2DXJCgGQ</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>ELLAURIE, M</creator><creator>RUBINSTEIN, A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19921101</creationdate><title>Tumor necrosis factor-α in pediatric HIV-1 infection</title><author>ELLAURIE, M ; RUBINSTEIN, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-f7f01d3dec439fcb3a6adbeac41dc2d4f5880929aabd2ad192cceb668b17823a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>AIDS Dementia Complex - blood</topic><topic>AIDS Dementia Complex - complications</topic><topic>AIDS-Related Opportunistic Infections - blood</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cachexia - blood</topic><topic>Cachexia - complications</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - diagnosis</topic><topic>HIV-1</topic><topic>human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Mycobacterium avium-intracellulare Infection - blood</topic><topic>Mycobacterium avium-intracellulare Infection - complications</topic><topic>Pneumonia, Pneumocystis - blood</topic><topic>Pneumonia, Pneumocystis - complications</topic><topic>Prognosis</topic><topic>Pulmonary Fibrosis - blood</topic><topic>Pulmonary Fibrosis - complications</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ELLAURIE, M</creatorcontrib><creatorcontrib>RUBINSTEIN, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ELLAURIE, M</au><au>RUBINSTEIN, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor necrosis factor-α in pediatric HIV-1 infection</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>6</volume><issue>11</issue><spage>1265</spage><epage>1268</epage><pages>1265-1268</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>To evaluate the diagnostic and prognostic value of serum tumor necrosis factor-alpha (TNF-alpha) levels in HIV-1-infected children.
Serum levels of TNF-alpha were evaluated in 57 HIV-1-infected symptomatic children aged between 7 months and 8 years.
TNF-alpha levels were determined by enzyme immunoassay. The sensitivity of the assay was 10 pg/ml.
TNF-alpha levels (mean +/- s.d.) were significantly elevated in HIV-1-infected patients (285 +/- 390 pg/ml), compared with HIV-1-uninfected age-matched controls (22.7 +/- 4.9 pg/ml). Among HIV-1-infected children the highest levels of TNF-alpha were noted in those with Mycobacterium avium intracellulare (MAI) infection and those with interstitial lymphoid pneumonitis (LIP). In contrast, patients with Pneumocystis carinii pneumonia, progressive encephalopathy or cachexia did not have markedly elevated TNF-alpha levels.
Serum TNF-alpha is increased in symptomatic HIV-1-infected children, with higher levels in children with LIP or MAI. Serum TNF-alpha levels are not diagnostic for cachexia or progressive encephalopathy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>1472332</pmid><doi>10.1097/00002030-199211000-00004</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 1992-11, Vol.6 (11), p.1265-1268 |
| issn | 0269-9370 1473-5571 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | AIDS Dementia Complex - blood AIDS Dementia Complex - complications AIDS-Related Opportunistic Infections - blood AIDS/HIV Biological and medical sciences Cachexia - blood Cachexia - complications Child Child, Preschool HIV Infections - blood HIV Infections - complications HIV Infections - diagnosis HIV-1 human immunodeficiency virus 1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant Medical sciences Mycobacterium avium-intracellulare Infection - blood Mycobacterium avium-intracellulare Infection - complications Pneumonia, Pneumocystis - blood Pneumonia, Pneumocystis - complications Prognosis Pulmonary Fibrosis - blood Pulmonary Fibrosis - complications Tumor Necrosis Factor-alpha - metabolism |
| title | Tumor necrosis factor-α in pediatric HIV-1 infection |
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