Enantioselective nitro-Michael reactions catalyzed by short peptides on water

Simple unmodified N-proline-based di- and tripeptides in combination with sodium hydroxide additive catalyze the asymmetric Michael reaction of ketones with nitroolefins to furnish the corresponding gamma-nitroketones with up to 99% yield, 99:1 dr and 70% ee at room temperature and on water without...

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Veröffentlicht in:	Organic & biomolecular chemistry 2009-01, Vol.7 (20), p.4279-4284
Hauptverfasser:	Freund, Matthias, Schenker, Sebastian, Tsogoeva, Svetlana B
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Ketones - chemistry Oligopeptides - chemistry Proline Stereoisomerism Styrene - chemistry Substrate Specificity Water - chemistry
Online-Zugang:	Volltext
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