Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non―Small Cell Lung Cancer Harboring K-RAS Mutations

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death worldwide. NSCLC often harbors oncogenic K-RAS mutations that lead to the aberrant activation of several intracellular networks including the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signal...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-10, Vol.69 (19), p.7644-7652
Hauptverfasser:	KONSTANTINIDOU, Georgia, BEY, Erik A, RABELLINO, Andrea, SCHUSTER, Katja, MAIRA, Michael S, GAZDAR, Adi F, AMICI, Augusto, BOOTHMAN, David A, SCAGLIONI, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis - drug effects Apoptosis - radiation effects Biological and medical sciences Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - therapy Cell Line, Tumor Combined Modality Therapy Female Genes, ras Humans Imidazoles - pharmacology Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - therapy Medical sciences Mice Mice, Nude Mutation Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Pneumology Protein Kinases - metabolism Quinolines - pharmacology Radiation-Sensitizing Agents - pharmacology TOR Serine-Threonine Kinases Tumors Tumors of the respiratory system and mediastinum Xenograft Model Antitumor Assays
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