Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats

Present study was designed to explore roles of metabolic clearance in the disposition of berberine (BBR) in rats, with a focus on oxidative metabolism and subsequent glucuronidation. Plasma from rats after intravenous administration of BBR was collected to identify and quantify BBR and its major met...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2009-11, Vol.98 (11), p.4391-4401
Hauptverfasser:	Liu, Yitong, Hao, Haiping, Xie, Hongguang, Lv, Hua, Liu, Changxiao, Wang, Guangji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BBR Berberine - chemistry Berberine - metabolism Biological and medical sciences CYPs Cytochrome P-450 Enzyme System - metabolism enzyme kinetics General pharmacology Glucuronides - metabolism Glucuronosyltransferase - metabolism Kinetics Male Medical sciences metabolic clearance Metabolic Networks and Pathways microsomes Microsomes, Liver - metabolism Molecular Structure Oxidation-Reduction Pharmaceutical technology. Pharmaceutical industry pharmacokinetics Pharmacology. Drug treatments Rats Rats, Sprague-Dawley UGTs
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