Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations
Coronary artery disease (CAD) and stroke are the major health problems in many countries because of their increasing prevalence and high mortality. It is well known that CAD and stroke are based on atherosclerosis and shared environmental and genetic risk factors. Recently, an association of a funct...
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| Veröffentlicht in: | Journal of human genetics 2009-09, Vol.54 (9), p.554-556 |
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| creator | Hinohara, Kunihiko Nakajima, Toshiaki Sasaoka, Taishi Sawabe, Motoji Lee, Bok-Soo Ban, Ji-Min Park, Jeong-Euy Izumi, Toru Kimura, Akinori |
| description | Coronary artery disease (CAD) and stroke are the major health problems in many countries because of their increasing prevalence and high mortality. It is well known that CAD and stroke are based on atherosclerosis and shared environmental and genetic risk factors. Recently, an association of a functional sequence variation −154G>A in the angiotensin receptor-like 1 (
AGTRL1
) with a susceptibility to stroke was reported. In this study, we investigated a total of 1479 CAD cases and 2062 controls from the Japanese and Korean populations to validate the association of
AGTRL1
with CAD. However, we obtained no evidence of the association in both the Japanese (odds ratio (OR)=0.95, 95% confidence interval (CI); 0.82–1.10,
P
=0.47, allele count model) and Korean (OR=0.90, 95% CI; 0.77–1.05,
P
=0.18, allele count model) populations. In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that
AGTRL1
did not contribute much to the atherosclerosis of the coronary artery. |
| doi_str_mv | 10.1038/jhg.2009.78 |
| format | Article |
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AGTRL1
) with a susceptibility to stroke was reported. In this study, we investigated a total of 1479 CAD cases and 2062 controls from the Japanese and Korean populations to validate the association of
AGTRL1
with CAD. However, we obtained no evidence of the association in both the Japanese (odds ratio (OR)=0.95, 95% confidence interval (CI); 0.82–1.10,
P
=0.47, allele count model) and Korean (OR=0.90, 95% CI; 0.77–1.05,
P
=0.18, allele count model) populations. In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that
AGTRL1
did not contribute much to the atherosclerosis of the coronary artery.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1038/jhg.2009.78</identifier><identifier>PMID: 19680269</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Alleles ; Angiotensin ; Apelin Receptors ; Arteriosclerosis ; Asian Continental Ancestry Group - genetics ; Atherosclerosis ; Biomedical and Life Sciences ; Biomedicine ; Cardiovascular disease ; Case-Control Studies ; Coronary artery ; Coronary Artery Disease - genetics ; Coronary vessels ; Female ; Gene Expression ; Gene Function ; Gene Therapy ; Health risk assessment ; Heart diseases ; Human Genetics ; Humans ; Korea ; Male ; Middle Aged ; Molecular Medicine ; Polymorphism, Genetic - genetics ; Population genetics ; Receptors, G-Protein-Coupled - genetics ; Risk factors ; short-communication ; Stroke</subject><ispartof>Journal of human genetics, 2009-09, Vol.54 (9), p.554-556</ispartof><rights>The Japan Society of Human Genetics 2009</rights><rights>The Japan Society of Human Genetics 2009.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-fc0698b4e3f5ada4de7786799214e376d835d504736a3582fc2788ac6549ce203</citedby><cites>FETCH-LOGICAL-c440t-fc0698b4e3f5ada4de7786799214e376d835d504736a3582fc2788ac6549ce203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhg.2009.78$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhg.2009.78$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19680269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hinohara, Kunihiko</creatorcontrib><creatorcontrib>Nakajima, Toshiaki</creatorcontrib><creatorcontrib>Sasaoka, Taishi</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Lee, Bok-Soo</creatorcontrib><creatorcontrib>Ban, Ji-Min</creatorcontrib><creatorcontrib>Park, Jeong-Euy</creatorcontrib><creatorcontrib>Izumi, Toru</creatorcontrib><creatorcontrib>Kimura, Akinori</creatorcontrib><title>Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>Coronary artery disease (CAD) and stroke are the major health problems in many countries because of their increasing prevalence and high mortality. It is well known that CAD and stroke are based on atherosclerosis and shared environmental and genetic risk factors. Recently, an association of a functional sequence variation −154G>A in the angiotensin receptor-like 1 (
AGTRL1
) with a susceptibility to stroke was reported. In this study, we investigated a total of 1479 CAD cases and 2062 controls from the Japanese and Korean populations to validate the association of
AGTRL1
with CAD. However, we obtained no evidence of the association in both the Japanese (odds ratio (OR)=0.95, 95% confidence interval (CI); 0.82–1.10,
P
=0.47, allele count model) and Korean (OR=0.90, 95% CI; 0.77–1.05,
P
=0.18, allele count model) populations. In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that
AGTRL1
did not contribute much to the atherosclerosis of the coronary artery.</description><subject>Aged</subject><subject>Alleles</subject><subject>Angiotensin</subject><subject>Apelin Receptors</subject><subject>Arteriosclerosis</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Atherosclerosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Function</subject><subject>Gene Therapy</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Korea</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Population genetics</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Risk factors</subject><subject>short-communication</subject><subject>Stroke</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc9LHDEUx0OxVGt78i4BDx7a2ebXJJmjiLWtC4LY0lvIZt64s8wkYzJDEfzjm9ldEMTTS14-fPJ4X4ROKFlQwvW3zfphwQipFkq_Q0dU8LJgnP092J5FUVJJD9HHlDaEEM4U-4AOaSU1YbI6Qs9_bNfWdmyDx6HB4xqwTSm4dtdawfgPwOOL6_u7JcVD6J76EId1m3psfY1diMHb-IRtHCGXuk1gE-DWb1W_7GA95PvM3oQI1mfHMHVbe_qE3je2S_B5X4_R7-9X95c_iuXt9c_Li2XhhCBj0TgiK70SwJvS1lbUoJSWqqoYzT0la83LuiRCcWl5qVnjmNLaOlmKygEj_Bid77xDDI8TpNH0bXLQdXm4MCWjuCCSCz2TZ6_ITZiiz8MZJljesqjITH3ZUS6GlCI0Zohtn9dgKDFzJiZnYuZMjNKZPt07p1UP9Qu7DyEDX3dAyk_-AeLLp2_5_gPFY5Zh</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Hinohara, Kunihiko</creator><creator>Nakajima, Toshiaki</creator><creator>Sasaoka, Taishi</creator><creator>Sawabe, Motoji</creator><creator>Lee, Bok-Soo</creator><creator>Ban, Ji-Min</creator><creator>Park, Jeong-Euy</creator><creator>Izumi, Toru</creator><creator>Kimura, Akinori</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations</title><author>Hinohara, Kunihiko ; Nakajima, Toshiaki ; Sasaoka, Taishi ; Sawabe, Motoji ; Lee, Bok-Soo ; Ban, Ji-Min ; Park, Jeong-Euy ; Izumi, Toru ; Kimura, Akinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-fc0698b4e3f5ada4de7786799214e376d835d504736a3582fc2788ac6549ce203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Angiotensin</topic><topic>Apelin Receptors</topic><topic>Arteriosclerosis</topic><topic>Asian Continental Ancestry Group - 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Academic</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hinohara, Kunihiko</au><au>Nakajima, Toshiaki</au><au>Sasaoka, Taishi</au><au>Sawabe, Motoji</au><au>Lee, Bok-Soo</au><au>Ban, Ji-Min</au><au>Park, Jeong-Euy</au><au>Izumi, Toru</au><au>Kimura, Akinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations</atitle><jtitle>Journal of human genetics</jtitle><stitle>J Hum Genet</stitle><addtitle>J Hum Genet</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>54</volume><issue>9</issue><spage>554</spage><epage>556</epage><pages>554-556</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Coronary artery disease (CAD) and stroke are the major health problems in many countries because of their increasing prevalence and high mortality. It is well known that CAD and stroke are based on atherosclerosis and shared environmental and genetic risk factors. Recently, an association of a functional sequence variation −154G>A in the angiotensin receptor-like 1 (
AGTRL1
) with a susceptibility to stroke was reported. In this study, we investigated a total of 1479 CAD cases and 2062 controls from the Japanese and Korean populations to validate the association of
AGTRL1
with CAD. However, we obtained no evidence of the association in both the Japanese (odds ratio (OR)=0.95, 95% confidence interval (CI); 0.82–1.10,
P
=0.47, allele count model) and Korean (OR=0.90, 95% CI; 0.77–1.05,
P
=0.18, allele count model) populations. In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that
AGTRL1
did not contribute much to the atherosclerosis of the coronary artery.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19680269</pmid><doi>10.1038/jhg.2009.78</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of human genetics, 2009-09, Vol.54 (9), p.554-556 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Aged Alleles Angiotensin Apelin Receptors Arteriosclerosis Asian Continental Ancestry Group - genetics Atherosclerosis Biomedical and Life Sciences Biomedicine Cardiovascular disease Case-Control Studies Coronary artery Coronary Artery Disease - genetics Coronary vessels Female Gene Expression Gene Function Gene Therapy Health risk assessment Heart diseases Human Genetics Humans Korea Male Middle Aged Molecular Medicine Polymorphism, Genetic - genetics Population genetics Receptors, G-Protein-Coupled - genetics Risk factors short-communication Stroke |
| title | Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations |
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