Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women
Acceleration of bone remodelling increases the risk of fragility fractures. The objective of the present study was to explore in elderly women whether a vitamin D and Ca-fortified dairy product providing about 17–25 % of the recommended intakes in vitamin D, Ca and proteins would reduce secondary hy...
Gespeichert in:
| Veröffentlicht in: | British journal of nutrition 2009-10, Vol.102 (7), p.962-966 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 966 |
|---|---|
| container_issue | 7 |
| container_start_page | 962 |
| container_title | British journal of nutrition |
| container_volume | 102 |
| creator | Bonjour, Jean-Philippe Benoit, Valérie Pourchaire, Olivier Ferry, Monique Rousseau, Brigitte Souberbielle, Jean-Claude |
| description | Acceleration of bone remodelling increases the risk of fragility fractures. The objective of the present study was to explore in elderly women whether a vitamin D and Ca-fortified dairy product providing about 17–25 % of the recommended intakes in vitamin D, Ca and proteins would reduce secondary hyperparathyroidism and bone remodelling in a way that may attenuate age-related bone loss in the long term. Thirty-seven institutionalised women, aged 84·8 (sd 8·1) years, with low serum 25-hydroxyvitamin D (5·5 (sd 1·7) ng/ml) were enrolled into a multicentre open trial to consume during 1 month two servings of soft plain cheese made of semi-skimmed milk providing daily 686 kJ (164 kcal), 2·5 μg vitamin D, 302 mg Ca and 14·2 g proteins. The primary endpoint was the change in serum carboxy terminal cross-linked telopeptide of type I collagen (CTX), selected as a marker of bone resorption. Thirty-five subjects remained compliant. Mean serum changes were: 25-hydroyvitamin D, +14·5 % (P = 0·0051); parathyroid hormone (PTH), − 12·3 % (P = 0·0011); CTX, − 7·5 % (P = 0·01); tartrate-resistant acid phosphatase isoform 5b (TRAP 5b), − 9·9 % (P |
| doi_str_mv | 10.1017/S0007114509371743 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734062665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0007114509371743</cupid><sourcerecordid>1914174421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c585t-bf08b221d2fbec0558340033b3e7735a190f6a3aeae52c3e9514eadc56b1569c3</originalsourceid><addsrcrecordid>eNp90cFu1DAQBuAIgehSeAAuECEBp4DHjuP4iApdCpUQWiqOluOMW5ckTu0E2KfglXHYpZVAcIqj-fxLvyfLHgJ5AQTEyw0hRACUnEgmQJTsVraCUvCCVhW9na2WcbHMD7J7MV6m3xqIvJsdgOQgpeCr7MfJcOEaNzk_5N7mvQ5fMMTl2PgB84DRh_HXtNnmxg9x7sff-KubdO-G_HWuhzY3ujNu7gvrw-SswzaP3k752OlEzAVixCXDDXFy07xk6M7FxLBrMXTb_Jvvcbif3bG6i_hg_z3Mzo7ffDp6W5x-WJ8cvTotDK_5VDSW1A2l0FLboCGc16wkhLGGoRCMa5DEVppp1MipYZj6lqhbw6sGeCUNO8ye73LH4K9mjJPqXTTYdXpAP0clUl6VnpEn-ey_kgLQSrIFPvkDXvo5pJaLYTWtOSsTgh0ywccY0KoxuPTqWwVELUtVfy013Xm0D56bHtubG_stJvB0D3RMa7BBD8bFa0dB1iUHklyxcy5O-P16nnauKsEEV9X6o3rPjj-_I-VGrZN_vPNWe6XPQ8o821ACjEAlRVnWSbB9Hd03wbXneFP634V-Aov90oM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213828534</pqid></control><display><type>article</type><title>Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Cambridge Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Bonjour, Jean-Philippe ; Benoit, Valérie ; Pourchaire, Olivier ; Ferry, Monique ; Rousseau, Brigitte ; Souberbielle, Jean-Claude</creator><creatorcontrib>Bonjour, Jean-Philippe ; Benoit, Valérie ; Pourchaire, Olivier ; Ferry, Monique ; Rousseau, Brigitte ; Souberbielle, Jean-Claude</creatorcontrib><description>Acceleration of bone remodelling increases the risk of fragility fractures. The objective of the present study was to explore in elderly women whether a vitamin D and Ca-fortified dairy product providing about 17–25 % of the recommended intakes in vitamin D, Ca and proteins would reduce secondary hyperparathyroidism and bone remodelling in a way that may attenuate age-related bone loss in the long term. Thirty-seven institutionalised women, aged 84·8 (sd 8·1) years, with low serum 25-hydroxyvitamin D (5·5 (sd 1·7) ng/ml) were enrolled into a multicentre open trial to consume during 1 month two servings of soft plain cheese made of semi-skimmed milk providing daily 686 kJ (164 kcal), 2·5 μg vitamin D, 302 mg Ca and 14·2 g proteins. The primary endpoint was the change in serum carboxy terminal cross-linked telopeptide of type I collagen (CTX), selected as a marker of bone resorption. Thirty-five subjects remained compliant. Mean serum changes were: 25-hydroyvitamin D, +14·5 % (P = 0·0051); parathyroid hormone (PTH), − 12·3 % (P = 0·0011); CTX, − 7·5 % (P = 0·01); tartrate-resistant acid phosphatase isoform 5b (TRAP 5b), − 9·9 % (P < 0·0001); albumin, +6·2 % (P < 0·0001); insulin-like growth factor-I (IGF-I),+16·9 % (P < 0·0001); osteocalcin, +8·3 % (P = 0·0166); amino-terminal propeptide of type 1 procollagen (P1NP),+19·3 % (P = 0·0031). The present open trial suggests that fortified soft plain cheese consumed by elderly women with vitamin D insufficiency can reduce bone resorption markers by positively influencing Ca and protein economy, as expressed by decreased PTH and increased IGF-I, respectively. The rise in the bone formation marker P1NP could be explained by a protein-mediated increase in IGF-I. Thus, such a dietary intervention might uncouple, at least transiently, bone resorption from bone formation and thereby attenuate age-related bone loss.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114509371743</identifier><identifier>PMID: 19519975</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject><![CDATA[Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Bone density ; bone resorption ; Bone Resorption - blood ; Bone Resorption - prevention & control ; Bone resorption and formation markers ; calcium ; Calcium and protein intakes ; Calcium, Dietary - administration & dosage ; Calcium, Dietary - therapeutic use ; Cheese ; Cheese - analysis ; Collagen Type I - blood ; Dairy products ; Diet ; dietary minerals ; dietary supplements ; elderly ; elderly nutrition ; Feeding. Feeding behavior ; Female ; Food, Fortified ; Fortified cheese ; fortified foods ; Fundamental and applied biological sciences. Psychology ; Homes for the Aged ; Humans ; Hyperparathyroidism, Secondary - etiology ; Hyperparathyroidism, Secondary - prevention & control ; inhibitors ; Insulin-like growth factor-I ; Nursing Homes ; Nutrition research ; Older people ; Peptides - blood ; Secondary hyperparathyroidism ; soft cheeses ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - therapeutic use ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - diet therapy ; Vitamins - administration & dosage ; Women]]></subject><ispartof>British journal of nutrition, 2009-10, Vol.102 (7), p.962-966</ispartof><rights>Copyright © The Authors 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-bf08b221d2fbec0558340033b3e7735a190f6a3aeae52c3e9514eadc56b1569c3</citedby><cites>FETCH-LOGICAL-c585t-bf08b221d2fbec0558340033b3e7735a190f6a3aeae52c3e9514eadc56b1569c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114509371743/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21984510$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19519975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonjour, Jean-Philippe</creatorcontrib><creatorcontrib>Benoit, Valérie</creatorcontrib><creatorcontrib>Pourchaire, Olivier</creatorcontrib><creatorcontrib>Ferry, Monique</creatorcontrib><creatorcontrib>Rousseau, Brigitte</creatorcontrib><creatorcontrib>Souberbielle, Jean-Claude</creatorcontrib><title>Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Acceleration of bone remodelling increases the risk of fragility fractures. The objective of the present study was to explore in elderly women whether a vitamin D and Ca-fortified dairy product providing about 17–25 % of the recommended intakes in vitamin D, Ca and proteins would reduce secondary hyperparathyroidism and bone remodelling in a way that may attenuate age-related bone loss in the long term. Thirty-seven institutionalised women, aged 84·8 (sd 8·1) years, with low serum 25-hydroxyvitamin D (5·5 (sd 1·7) ng/ml) were enrolled into a multicentre open trial to consume during 1 month two servings of soft plain cheese made of semi-skimmed milk providing daily 686 kJ (164 kcal), 2·5 μg vitamin D, 302 mg Ca and 14·2 g proteins. The primary endpoint was the change in serum carboxy terminal cross-linked telopeptide of type I collagen (CTX), selected as a marker of bone resorption. Thirty-five subjects remained compliant. Mean serum changes were: 25-hydroyvitamin D, +14·5 % (P = 0·0051); parathyroid hormone (PTH), − 12·3 % (P = 0·0011); CTX, − 7·5 % (P = 0·01); tartrate-resistant acid phosphatase isoform 5b (TRAP 5b), − 9·9 % (P < 0·0001); albumin, +6·2 % (P < 0·0001); insulin-like growth factor-I (IGF-I),+16·9 % (P < 0·0001); osteocalcin, +8·3 % (P = 0·0166); amino-terminal propeptide of type 1 procollagen (P1NP),+19·3 % (P = 0·0031). The present open trial suggests that fortified soft plain cheese consumed by elderly women with vitamin D insufficiency can reduce bone resorption markers by positively influencing Ca and protein economy, as expressed by decreased PTH and increased IGF-I, respectively. The rise in the bone formation marker P1NP could be explained by a protein-mediated increase in IGF-I. Thus, such a dietary intervention might uncouple, at least transiently, bone resorption from bone formation and thereby attenuate age-related bone loss.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bone density</subject><subject>bone resorption</subject><subject>Bone Resorption - blood</subject><subject>Bone Resorption - prevention & control</subject><subject>Bone resorption and formation markers</subject><subject>calcium</subject><subject>Calcium and protein intakes</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Calcium, Dietary - therapeutic use</subject><subject>Cheese</subject><subject>Cheese - analysis</subject><subject>Collagen Type I - blood</subject><subject>Dairy products</subject><subject>Diet</subject><subject>dietary minerals</subject><subject>dietary supplements</subject><subject>elderly</subject><subject>elderly nutrition</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food, Fortified</subject><subject>Fortified cheese</subject><subject>fortified foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homes for the Aged</subject><subject>Humans</subject><subject>Hyperparathyroidism, Secondary - etiology</subject><subject>Hyperparathyroidism, Secondary - prevention & control</subject><subject>inhibitors</subject><subject>Insulin-like growth factor-I</subject><subject>Nursing Homes</subject><subject>Nutrition research</subject><subject>Older people</subject><subject>Peptides - blood</subject><subject>Secondary hyperparathyroidism</subject><subject>soft cheeses</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - therapeutic use</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - diet therapy</subject><subject>Vitamins - administration & dosage</subject><subject>Women</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90cFu1DAQBuAIgehSeAAuECEBp4DHjuP4iApdCpUQWiqOluOMW5ckTu0E2KfglXHYpZVAcIqj-fxLvyfLHgJ5AQTEyw0hRACUnEgmQJTsVraCUvCCVhW9na2WcbHMD7J7MV6m3xqIvJsdgOQgpeCr7MfJcOEaNzk_5N7mvQ5fMMTl2PgB84DRh_HXtNnmxg9x7sff-KubdO-G_HWuhzY3ujNu7gvrw-SswzaP3k752OlEzAVixCXDDXFy07xk6M7FxLBrMXTb_Jvvcbif3bG6i_hg_z3Mzo7ffDp6W5x-WJ8cvTotDK_5VDSW1A2l0FLboCGc16wkhLGGoRCMa5DEVppp1MipYZj6lqhbw6sGeCUNO8ye73LH4K9mjJPqXTTYdXpAP0clUl6VnpEn-ey_kgLQSrIFPvkDXvo5pJaLYTWtOSsTgh0ywccY0KoxuPTqWwVELUtVfy013Xm0D56bHtubG_stJvB0D3RMa7BBD8bFa0dB1iUHklyxcy5O-P16nnauKsEEV9X6o3rPjj-_I-VGrZN_vPNWe6XPQ8o821ACjEAlRVnWSbB9Hd03wbXneFP634V-Aov90oM</recordid><startdate>20091014</startdate><enddate>20091014</enddate><creator>Bonjour, Jean-Philippe</creator><creator>Benoit, Valérie</creator><creator>Pourchaire, Olivier</creator><creator>Ferry, Monique</creator><creator>Rousseau, Brigitte</creator><creator>Souberbielle, Jean-Claude</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20091014</creationdate><title>Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women</title><author>Bonjour, Jean-Philippe ; Benoit, Valérie ; Pourchaire, Olivier ; Ferry, Monique ; Rousseau, Brigitte ; Souberbielle, Jean-Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-bf08b221d2fbec0558340033b3e7735a190f6a3aeae52c3e9514eadc56b1569c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Bone density</topic><topic>bone resorption</topic><topic>Bone Resorption - blood</topic><topic>Bone Resorption - prevention & control</topic><topic>Bone resorption and formation markers</topic><topic>calcium</topic><topic>Calcium and protein intakes</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Calcium, Dietary - therapeutic use</topic><topic>Cheese</topic><topic>Cheese - analysis</topic><topic>Collagen Type I - blood</topic><topic>Dairy products</topic><topic>Diet</topic><topic>dietary minerals</topic><topic>dietary supplements</topic><topic>elderly</topic><topic>elderly nutrition</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food, Fortified</topic><topic>Fortified cheese</topic><topic>fortified foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Homes for the Aged</topic><topic>Humans</topic><topic>Hyperparathyroidism, Secondary - etiology</topic><topic>Hyperparathyroidism, Secondary - prevention & control</topic><topic>inhibitors</topic><topic>Insulin-like growth factor-I</topic><topic>Nursing Homes</topic><topic>Nutrition research</topic><topic>Older people</topic><topic>Peptides - blood</topic><topic>Secondary hyperparathyroidism</topic><topic>soft cheeses</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - therapeutic use</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - diet therapy</topic><topic>Vitamins - administration & dosage</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonjour, Jean-Philippe</creatorcontrib><creatorcontrib>Benoit, Valérie</creatorcontrib><creatorcontrib>Pourchaire, Olivier</creatorcontrib><creatorcontrib>Ferry, Monique</creatorcontrib><creatorcontrib>Rousseau, Brigitte</creatorcontrib><creatorcontrib>Souberbielle, Jean-Claude</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonjour, Jean-Philippe</au><au>Benoit, Valérie</au><au>Pourchaire, Olivier</au><au>Ferry, Monique</au><au>Rousseau, Brigitte</au><au>Souberbielle, Jean-Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2009-10-14</date><risdate>2009</risdate><volume>102</volume><issue>7</issue><spage>962</spage><epage>966</epage><pages>962-966</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Acceleration of bone remodelling increases the risk of fragility fractures. The objective of the present study was to explore in elderly women whether a vitamin D and Ca-fortified dairy product providing about 17–25 % of the recommended intakes in vitamin D, Ca and proteins would reduce secondary hyperparathyroidism and bone remodelling in a way that may attenuate age-related bone loss in the long term. Thirty-seven institutionalised women, aged 84·8 (sd 8·1) years, with low serum 25-hydroxyvitamin D (5·5 (sd 1·7) ng/ml) were enrolled into a multicentre open trial to consume during 1 month two servings of soft plain cheese made of semi-skimmed milk providing daily 686 kJ (164 kcal), 2·5 μg vitamin D, 302 mg Ca and 14·2 g proteins. The primary endpoint was the change in serum carboxy terminal cross-linked telopeptide of type I collagen (CTX), selected as a marker of bone resorption. Thirty-five subjects remained compliant. Mean serum changes were: 25-hydroyvitamin D, +14·5 % (P = 0·0051); parathyroid hormone (PTH), − 12·3 % (P = 0·0011); CTX, − 7·5 % (P = 0·01); tartrate-resistant acid phosphatase isoform 5b (TRAP 5b), − 9·9 % (P < 0·0001); albumin, +6·2 % (P < 0·0001); insulin-like growth factor-I (IGF-I),+16·9 % (P < 0·0001); osteocalcin, +8·3 % (P = 0·0166); amino-terminal propeptide of type 1 procollagen (P1NP),+19·3 % (P = 0·0031). The present open trial suggests that fortified soft plain cheese consumed by elderly women with vitamin D insufficiency can reduce bone resorption markers by positively influencing Ca and protein economy, as expressed by decreased PTH and increased IGF-I, respectively. The rise in the bone formation marker P1NP could be explained by a protein-mediated increase in IGF-I. Thus, such a dietary intervention might uncouple, at least transiently, bone resorption from bone formation and thereby attenuate age-related bone loss.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>19519975</pmid><doi>10.1017/S0007114509371743</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2009-10, Vol.102 (7), p.962-966 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734062665 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cambridge Journals; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Biological and medical sciences Biomarkers Biomarkers - blood Bone density bone resorption Bone Resorption - blood Bone Resorption - prevention & control Bone resorption and formation markers calcium Calcium and protein intakes Calcium, Dietary - administration & dosage Calcium, Dietary - therapeutic use Cheese Cheese - analysis Collagen Type I - blood Dairy products Diet dietary minerals dietary supplements elderly elderly nutrition Feeding. Feeding behavior Female Food, Fortified Fortified cheese fortified foods Fundamental and applied biological sciences. Psychology Homes for the Aged Humans Hyperparathyroidism, Secondary - etiology Hyperparathyroidism, Secondary - prevention & control inhibitors Insulin-like growth factor-I Nursing Homes Nutrition research Older people Peptides - blood Secondary hyperparathyroidism soft cheeses Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - therapeutic use Vitamin D Deficiency - complications Vitamin D Deficiency - diet therapy Vitamins - administration & dosage Women |
| title | Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T02%3A20%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibition%20of%20markers%20of%20bone%20resorption%20by%20consumption%20of%20vitamin%20D%20and%20calcium-fortified%20soft%20plain%20cheese%20by%20institutionalised%20elderly%20women&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Bonjour,%20Jean-Philippe&rft.date=2009-10-14&rft.volume=102&rft.issue=7&rft.spage=962&rft.epage=966&rft.pages=962-966&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114509371743&rft_dat=%3Cproquest_cross%3E1914174421%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213828534&rft_id=info:pmid/19519975&rft_cupid=10_1017_S0007114509371743&rfr_iscdi=true |