In patients with heart failure and non-ischemic heart disease, cardiac troponin T is a reliable predictor of long-term echocardiographic changes and adverse cardiac events
Summary Background The relationships between (1) serum concentration of cardiac troponin T (cTnT) and clinical hemodynamic profiles, (2) cTnT versus B-type natriuretic peptide (BNP) and long-term echocardiographic changes, and (3) cTnT versus BNP and echocardiographic changes, and rates of adverse c...
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| Veröffentlicht in: | Journal of cardiology 2009-10, Vol.54 (2), p.221-230 |
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| creator | Sato, Yukihito, MD, PhD, FJCC Nishi, Kiyoto, MD Taniguchi, Ryoji, MD, PhD Miyamoto, Tadashi, MD, PhD Fukuhara, Rei, MD Yamane, Keiichiro, MD Saijyo, Sayaka, MD Tanada, Yohei, MD Yamamoto, Erika, MD Goto, Taisuke, MD Takahashi, Naoki, MD Fujiwara, Hisayoshi, MD, PhD, FJCC Takatsu, Yoshiki, MD, PhD |
| description | Summary Background The relationships between (1) serum concentration of cardiac troponin T (cTnT) and clinical hemodynamic profiles, (2) cTnT versus B-type natriuretic peptide (BNP) and long-term echocardiographic changes, and (3) cTnT versus BNP and echocardiographic changes, and rates of adverse cardiac events, have not been well elucidated. Methods Retrospective analysis of 100 consecutive patients with heart failure, left ventricular ejection fraction |
| doi_str_mv | 10.1016/j.jjcc.2009.05.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734060831</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0914508709001774</els_id><sourcerecordid>734060831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-8fb4d5aa98a60d70985640a4dcf0a12b8cca62dc7784bce4befbbdb0854fe9803</originalsourceid><addsrcrecordid>eNp9ks2O1DAQhCMEYoeFF-CAfONChnYmiR0JIa1W_Ky0EgeWs9WxOxOHjB3sZNA-Ey-JszMCiQMnH1xVdvXXWfaSw5YDr98O22HQelsANFuotgDiUbbhUtR5KXbycbaBhpd5BVJcZM9iHABqaGT9NLvgjZBFUTWb7NeNYxPOltwc2U8796wnDDPr0I5LIIbOMOddbqPu6WD1-drYSBjpDdMYjEXN5uAn76xjd8xGhizQaLEdiU2BjNWzD8x3bPRun88UDox07x-8fh9w6lOw7tHtKT68iOZIIdKfdDqu_3uePelwjPTifF5m3z5-uLv-nN9--XRzfXWb6wrEnMuuLU2F2EiswYhUuapLwNLoDpAXrdQa68JoIWTZaipb6trWtCCrsqNGwu4ye33KnYL_sVCc1SHVp3FER36JSuzKNEm540lZnJQ6-BgDdWoK9oDhXnFQKyM1qJWRWhkpqFRilEyvzvFLeyDz13KGkgTvTgJKJY-Wgoo6AdJpkIH0rIy3_89__49dj9ZZjeN3uqc4-CW4ND7FVSwUqK_rlqxLAg0AF6Lc_QYj8Lv3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734060831</pqid></control><display><type>article</type><title>In patients with heart failure and non-ischemic heart disease, cardiac troponin T is a reliable predictor of long-term echocardiographic changes and adverse cardiac events</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Sato, Yukihito, MD, PhD, FJCC ; Nishi, Kiyoto, MD ; Taniguchi, Ryoji, MD, PhD ; Miyamoto, Tadashi, MD, PhD ; Fukuhara, Rei, MD ; Yamane, Keiichiro, MD ; Saijyo, Sayaka, MD ; Tanada, Yohei, MD ; Yamamoto, Erika, MD ; Goto, Taisuke, MD ; Takahashi, Naoki, MD ; Fujiwara, Hisayoshi, MD, PhD, FJCC ; Takatsu, Yoshiki, MD, PhD</creator><creatorcontrib>Sato, Yukihito, MD, PhD, FJCC ; Nishi, Kiyoto, MD ; Taniguchi, Ryoji, MD, PhD ; Miyamoto, Tadashi, MD, PhD ; Fukuhara, Rei, MD ; Yamane, Keiichiro, MD ; Saijyo, Sayaka, MD ; Tanada, Yohei, MD ; Yamamoto, Erika, MD ; Goto, Taisuke, MD ; Takahashi, Naoki, MD ; Fujiwara, Hisayoshi, MD, PhD, FJCC ; Takatsu, Yoshiki, MD, PhD</creatorcontrib><description>Summary Background The relationships between (1) serum concentration of cardiac troponin T (cTnT) and clinical hemodynamic profiles, (2) cTnT versus B-type natriuretic peptide (BNP) and long-term echocardiographic changes, and (3) cTnT versus BNP and echocardiographic changes, and rates of adverse cardiac events, have not been well elucidated. Methods Retrospective analysis of 100 consecutive patients with heart failure, left ventricular ejection fraction <50%, and non-ischemic heart disease was performed. Results Baseline cTnT was ≥0.01 ng/ml in 30 patients. By multiple variable logistic regression analysis, diabetes mellitus [DM; odds ratio (OR) 7.5; p = 0.014], serum creatinine (OR 25.9; p = 0.0157), and pulmonary capillary wedge pressure (PCWP; OR 1.12; p = 0.0214) were independent predictors of baseline elevation of cTnT. At a follow-up of 40.6 ± 20.6 months, echocardiograms and cTnT and BNP measurements were available in 93 patients, of whom 23 experienced an adverse cardiac event. By multiple variable analyses, elevated cTnT at follow-up was negatively correlated with echocardiographic improvements in cardiac function (OR 0.10; p = 0.019), and was a significant predictor of adverse cardiac events after adjustment for covariables, including follow-up BNP and echocardiographic changes (hazard ratio 5.6; p = 0.0046). Conclusions DM, serum creatinine, and PCWP were correlated with elevated baseline serum cTnT concentrations. cTnT concentration during follow-up might be a surrogate marker of heart failure.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2009.05.007</identifier><identifier>PMID: 19782259</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; Biomarkers - blood ; Cardiovascular ; Creatinine - blood ; Diabetes Mellitus ; Echocardiography ; Female ; Follow-Up Studies ; Heart failure ; Heart Failure - diagnosis ; Humans ; Logistic Models ; Male ; Middle Aged ; Natriuretic peptide ; Natriuretic Peptide, Brain - blood ; Predictive Value of Tests ; Pulmonary Wedge Pressure ; Remodeling ; Retrospective Studies ; Surrogate marker ; Troponin ; Troponin T - blood</subject><ispartof>Journal of cardiology, 2009-10, Vol.54 (2), p.221-230</ispartof><rights>Japanese College of Cardiology</rights><rights>2009 Japanese College of Cardiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-8fb4d5aa98a60d70985640a4dcf0a12b8cca62dc7784bce4befbbdb0854fe9803</citedby><cites>FETCH-LOGICAL-c507t-8fb4d5aa98a60d70985640a4dcf0a12b8cca62dc7784bce4befbbdb0854fe9803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0914508709001774$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19782259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Yukihito, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Nishi, Kiyoto, MD</creatorcontrib><creatorcontrib>Taniguchi, Ryoji, MD, PhD</creatorcontrib><creatorcontrib>Miyamoto, Tadashi, MD, PhD</creatorcontrib><creatorcontrib>Fukuhara, Rei, MD</creatorcontrib><creatorcontrib>Yamane, Keiichiro, MD</creatorcontrib><creatorcontrib>Saijyo, Sayaka, MD</creatorcontrib><creatorcontrib>Tanada, Yohei, MD</creatorcontrib><creatorcontrib>Yamamoto, Erika, MD</creatorcontrib><creatorcontrib>Goto, Taisuke, MD</creatorcontrib><creatorcontrib>Takahashi, Naoki, MD</creatorcontrib><creatorcontrib>Fujiwara, Hisayoshi, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Takatsu, Yoshiki, MD, PhD</creatorcontrib><title>In patients with heart failure and non-ischemic heart disease, cardiac troponin T is a reliable predictor of long-term echocardiographic changes and adverse cardiac events</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Summary Background The relationships between (1) serum concentration of cardiac troponin T (cTnT) and clinical hemodynamic profiles, (2) cTnT versus B-type natriuretic peptide (BNP) and long-term echocardiographic changes, and (3) cTnT versus BNP and echocardiographic changes, and rates of adverse cardiac events, have not been well elucidated. Methods Retrospective analysis of 100 consecutive patients with heart failure, left ventricular ejection fraction <50%, and non-ischemic heart disease was performed. Results Baseline cTnT was ≥0.01 ng/ml in 30 patients. By multiple variable logistic regression analysis, diabetes mellitus [DM; odds ratio (OR) 7.5; p = 0.014], serum creatinine (OR 25.9; p = 0.0157), and pulmonary capillary wedge pressure (PCWP; OR 1.12; p = 0.0214) were independent predictors of baseline elevation of cTnT. At a follow-up of 40.6 ± 20.6 months, echocardiograms and cTnT and BNP measurements were available in 93 patients, of whom 23 experienced an adverse cardiac event. By multiple variable analyses, elevated cTnT at follow-up was negatively correlated with echocardiographic improvements in cardiac function (OR 0.10; p = 0.019), and was a significant predictor of adverse cardiac events after adjustment for covariables, including follow-up BNP and echocardiographic changes (hazard ratio 5.6; p = 0.0046). Conclusions DM, serum creatinine, and PCWP were correlated with elevated baseline serum cTnT concentrations. cTnT concentration during follow-up might be a surrogate marker of heart failure.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular</subject><subject>Creatinine - blood</subject><subject>Diabetes Mellitus</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic peptide</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Predictive Value of Tests</subject><subject>Pulmonary Wedge Pressure</subject><subject>Remodeling</subject><subject>Retrospective Studies</subject><subject>Surrogate marker</subject><subject>Troponin</subject><subject>Troponin T - blood</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks2O1DAQhCMEYoeFF-CAfONChnYmiR0JIa1W_Ky0EgeWs9WxOxOHjB3sZNA-Ey-JszMCiQMnH1xVdvXXWfaSw5YDr98O22HQelsANFuotgDiUbbhUtR5KXbycbaBhpd5BVJcZM9iHABqaGT9NLvgjZBFUTWb7NeNYxPOltwc2U8796wnDDPr0I5LIIbOMOddbqPu6WD1-drYSBjpDdMYjEXN5uAn76xjd8xGhizQaLEdiU2BjNWzD8x3bPRun88UDox07x-8fh9w6lOw7tHtKT68iOZIIdKfdDqu_3uePelwjPTifF5m3z5-uLv-nN9--XRzfXWb6wrEnMuuLU2F2EiswYhUuapLwNLoDpAXrdQa68JoIWTZaipb6trWtCCrsqNGwu4ye33KnYL_sVCc1SHVp3FER36JSuzKNEm540lZnJQ6-BgDdWoK9oDhXnFQKyM1qJWRWhkpqFRilEyvzvFLeyDz13KGkgTvTgJKJY-Wgoo6AdJpkIH0rIy3_89__49dj9ZZjeN3uqc4-CW4ND7FVSwUqK_rlqxLAg0AF6Lc_QYj8Lv3</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Sato, Yukihito, MD, PhD, FJCC</creator><creator>Nishi, Kiyoto, MD</creator><creator>Taniguchi, Ryoji, MD, PhD</creator><creator>Miyamoto, Tadashi, MD, PhD</creator><creator>Fukuhara, Rei, MD</creator><creator>Yamane, Keiichiro, MD</creator><creator>Saijyo, Sayaka, MD</creator><creator>Tanada, Yohei, MD</creator><creator>Yamamoto, Erika, MD</creator><creator>Goto, Taisuke, MD</creator><creator>Takahashi, Naoki, MD</creator><creator>Fujiwara, Hisayoshi, MD, PhD, FJCC</creator><creator>Takatsu, Yoshiki, MD, PhD</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>In patients with heart failure and non-ischemic heart disease, cardiac troponin T is a reliable predictor of long-term echocardiographic changes and adverse cardiac events</title><author>Sato, Yukihito, MD, PhD, FJCC ; Nishi, Kiyoto, MD ; Taniguchi, Ryoji, MD, PhD ; Miyamoto, Tadashi, MD, PhD ; Fukuhara, Rei, MD ; Yamane, Keiichiro, MD ; Saijyo, Sayaka, MD ; Tanada, Yohei, MD ; Yamamoto, Erika, MD ; Goto, Taisuke, MD ; Takahashi, Naoki, MD ; Fujiwara, Hisayoshi, MD, PhD, FJCC ; Takatsu, Yoshiki, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-8fb4d5aa98a60d70985640a4dcf0a12b8cca62dc7784bce4befbbdb0854fe9803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular</topic><topic>Creatinine - blood</topic><topic>Diabetes Mellitus</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic peptide</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Predictive Value of Tests</topic><topic>Pulmonary Wedge Pressure</topic><topic>Remodeling</topic><topic>Retrospective Studies</topic><topic>Surrogate marker</topic><topic>Troponin</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Yukihito, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Nishi, Kiyoto, MD</creatorcontrib><creatorcontrib>Taniguchi, Ryoji, MD, PhD</creatorcontrib><creatorcontrib>Miyamoto, Tadashi, MD, PhD</creatorcontrib><creatorcontrib>Fukuhara, Rei, MD</creatorcontrib><creatorcontrib>Yamane, Keiichiro, MD</creatorcontrib><creatorcontrib>Saijyo, Sayaka, MD</creatorcontrib><creatorcontrib>Tanada, Yohei, MD</creatorcontrib><creatorcontrib>Yamamoto, Erika, MD</creatorcontrib><creatorcontrib>Goto, Taisuke, MD</creatorcontrib><creatorcontrib>Takahashi, Naoki, MD</creatorcontrib><creatorcontrib>Fujiwara, Hisayoshi, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Takatsu, Yoshiki, MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Yukihito, MD, PhD, FJCC</au><au>Nishi, Kiyoto, MD</au><au>Taniguchi, Ryoji, MD, PhD</au><au>Miyamoto, Tadashi, MD, PhD</au><au>Fukuhara, Rei, MD</au><au>Yamane, Keiichiro, MD</au><au>Saijyo, Sayaka, MD</au><au>Tanada, Yohei, MD</au><au>Yamamoto, Erika, MD</au><au>Goto, Taisuke, MD</au><au>Takahashi, Naoki, MD</au><au>Fujiwara, Hisayoshi, MD, PhD, FJCC</au><au>Takatsu, Yoshiki, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In patients with heart failure and non-ischemic heart disease, cardiac troponin T is a reliable predictor of long-term echocardiographic changes and adverse cardiac events</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>54</volume><issue>2</issue><spage>221</spage><epage>230</epage><pages>221-230</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Summary Background The relationships between (1) serum concentration of cardiac troponin T (cTnT) and clinical hemodynamic profiles, (2) cTnT versus B-type natriuretic peptide (BNP) and long-term echocardiographic changes, and (3) cTnT versus BNP and echocardiographic changes, and rates of adverse cardiac events, have not been well elucidated. Methods Retrospective analysis of 100 consecutive patients with heart failure, left ventricular ejection fraction <50%, and non-ischemic heart disease was performed. Results Baseline cTnT was ≥0.01 ng/ml in 30 patients. By multiple variable logistic regression analysis, diabetes mellitus [DM; odds ratio (OR) 7.5; p = 0.014], serum creatinine (OR 25.9; p = 0.0157), and pulmonary capillary wedge pressure (PCWP; OR 1.12; p = 0.0214) were independent predictors of baseline elevation of cTnT. At a follow-up of 40.6 ± 20.6 months, echocardiograms and cTnT and BNP measurements were available in 93 patients, of whom 23 experienced an adverse cardiac event. By multiple variable analyses, elevated cTnT at follow-up was negatively correlated with echocardiographic improvements in cardiac function (OR 0.10; p = 0.019), and was a significant predictor of adverse cardiac events after adjustment for covariables, including follow-up BNP and echocardiographic changes (hazard ratio 5.6; p = 0.0046). Conclusions DM, serum creatinine, and PCWP were correlated with elevated baseline serum cTnT concentrations. cTnT concentration during follow-up might be a surrogate marker of heart failure.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>19782259</pmid><doi>10.1016/j.jjcc.2009.05.007</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers - blood Cardiovascular Creatinine - blood Diabetes Mellitus Echocardiography Female Follow-Up Studies Heart failure Heart Failure - diagnosis Humans Logistic Models Male Middle Aged Natriuretic peptide Natriuretic Peptide, Brain - blood Predictive Value of Tests Pulmonary Wedge Pressure Remodeling Retrospective Studies Surrogate marker Troponin Troponin T - blood |
| title | In patients with heart failure and non-ischemic heart disease, cardiac troponin T is a reliable predictor of long-term echocardiographic changes and adverse cardiac events |
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