The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes

Abstract Aim Genome-wide association studies have shown that variation in the FTO gene predisposes to obesity and related traits that are common features of polycystic ovary syndrome (PCOS). The aim of the present study was to assess the effect of FTO variation on obesity, insulin sensitivity, and m...

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Veröffentlicht in:	Diabetes & metabolism 2009-09, Vol.35 (4), p.328-331
Hauptverfasser:	Kowalska, I, Malecki, M.T, Straczkowski, M, Skupien, J, Karczewska-Kupczewska, M, Nikolajuk, A, Szopa, M, Adamska, A, Wawrusiewicz-Kurylonek, N, Wołczynski, S, Sieradzki, J, Gorska, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity - genetics Adult Alpha-Ketoglutarate-Dependent Dioxygenase FTO Biological and medical sciences Body Composition - genetics Body Mass Index Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinology & Metabolism Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fat mass Female Female genital diseases FTO gene variation Gene Frequency Genetic Association Studies Glucose Clamp Technique Glucose Tolerance Test Gonadal Steroid Hormones - blood Gynecology. Andrology. Obstetrics Humans Insulin Resistance - genetics Insulin sensitivity Internal Medicine Masse grasse Medical sciences Non tumoral diseases Obesity - complications Poland Polycystic ovary syndrome Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - physiopathology Polymorphism, Genetic Polymorphismes du gène de FTO Proteins - genetics Proteins - physiology Sensibilité à l’insuline Syndrome des ovaires polykystiques Waist Circumference Young Adult
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