Determination of MDL 201,012 at femtomole/millilitre levels in human plasma by liquid chromatography with electrochemical detection

A sensitive and selective liquid chromatographic method to quantitate MDL 201,012 in human plasma was developed and validated. MDL 201,012 (I), diethyl‐MDL 201,012 (internal standard, II) and desmethyldiol‐MDL 201,012 (masking agent, III) were isolated from basified plasma (2 mL) by solid phase extr...

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Veröffentlicht in:	Biomedical chromatography 1992-11, Vol.6 (6), p.295-299
Hauptverfasser:	Reynolds, Donald L., Eichmeier, Larry S., Giesing, Dennis H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - blood Amines Chromatography, High Pressure Liquid Cyclobutanes - blood Electrochemistry Electrodes Humans Hydrogen-Ion Concentration Indicators and Reagents Quality Control Solvents Spectrophotometry, Ultraviolet Urinary Bladder, Neurogenic - drug therapy
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