Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production

Neprilysin (NEP, neutral endopeptidase, EC3.4.24.11), a zinc metallopeptidase expressed on the surface of endothelial cells, influences vascular homeostasis primarily through regulated inactivation of natriuretic peptides and bradykinin. Earlier in vivo studies reporting on the anti-atherosclerotic...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2009-11, Vol.41 (11), p.2287-2294
Hauptverfasser:	Fitzpatrick, Paul A., Guinan, Anthony F., Walsh, Tony G., Murphy, Ronan P., Killeen, Maria T., Tobin, Nicholas P., Pierotti, Adrian R., Cummins, Philip M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Down-Regulation - genetics Endothelial Cells - cytology Endothelial Cells - enzymology Endothelium GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - metabolism Laminar shear stress NADPH oxidase NADPH Oxidases - metabolism Neprilysin Neprilysin - genetics Neprilysin - metabolism Protein-Tyrosine Kinases - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Stress, Mechanical
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