Treatment of MRSA Infections in an African-American Male with G6PD Deficiency
Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency affecting erythrocytes is the most common enzymopathy in humans. It requires caution with the intake of oxidizing substances (e.g., medications and foods) because of the threat of hemolysis. Less recognized is the threat of a deficiency in...
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| Veröffentlicht in: | The Journal of emergency medicine 2009-10, Vol.37 (3), p.273-278 |
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| container_title | The Journal of emergency medicine |
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| creator | Paek, David S., MD Nadkarni, Milan, MD Singla, Manav, MD |
| description | Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency affecting erythrocytes is the most common enzymopathy in humans. It requires caution with the intake of oxidizing substances (e.g., medications and foods) because of the threat of hemolysis. Less recognized is the threat of a deficiency in G6PD that alters neutrophil function, which can compromise the killing of microbes by the oxidative burst mechanism. This results from a secondary alteration in the NADPH oxidase pathway. Methicillin-resistant Staphylococcus aureus (MRSA) infection, which is usually observed after exposure in the hospital setting, is becoming increasingly common in a community setting. Here we show the risk of MRSA and G6PD deficiency and discuss the pitfalls of G6PD deficiency. |
| doi_str_mv | 10.1016/j.jemermed.2007.10.049 |
| format | Article |
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It requires caution with the intake of oxidizing substances (e.g., medications and foods) because of the threat of hemolysis. Less recognized is the threat of a deficiency in G6PD that alters neutrophil function, which can compromise the killing of microbes by the oxidative burst mechanism. This results from a secondary alteration in the NADPH oxidase pathway. Methicillin-resistant Staphylococcus aureus (MRSA) infection, which is usually observed after exposure in the hospital setting, is becoming increasingly common in a community setting. 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It requires caution with the intake of oxidizing substances (e.g., medications and foods) because of the threat of hemolysis. Less recognized is the threat of a deficiency in G6PD that alters neutrophil function, which can compromise the killing of microbes by the oxidative burst mechanism. This results from a secondary alteration in the NADPH oxidase pathway. Methicillin-resistant Staphylococcus aureus (MRSA) infection, which is usually observed after exposure in the hospital setting, is becoming increasingly common in a community setting. 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Nadkarni, Milan, MD ; Singla, Manav, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-e2ee4132fc23da823a9b9e70249737d5b2250624145af133eb4d920dfb71f3df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>African Americans</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Child, Preschool</topic><topic>chronic granulomatous disease (CGD)</topic><topic>Clindamycin - therapeutic use</topic><topic>Emergency</topic><topic>Emergency Service, Hospital</topic><topic>glucose-6-phosphate dehydrogenase (G6PD)</topic><topic>Glucosephosphate Dehydrogenase Deficiency - complications</topic><topic>Glucosephosphate Dehydrogenase Deficiency - diagnosis</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>methicillin-resistant Staphylococcus aureus (MRSA)</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>Recurrence</topic><topic>Soft Tissue Infections - complications</topic><topic>Soft Tissue Infections - drug therapy</topic><topic>Soft Tissue Infections - ethnology</topic><topic>Staphylococcal Infections - complications</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - ethnology</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paek, David S., MD</creatorcontrib><creatorcontrib>Nadkarni, Milan, MD</creatorcontrib><creatorcontrib>Singla, Manav, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paek, David S., MD</au><au>Nadkarni, Milan, MD</au><au>Singla, Manav, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of MRSA Infections in an African-American Male with G6PD Deficiency</atitle><jtitle>The Journal of emergency medicine</jtitle><addtitle>J Emerg Med</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>37</volume><issue>3</issue><spage>273</spage><epage>278</epage><pages>273-278</pages><issn>0736-4679</issn><eissn>2352-5029</eissn><abstract>Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency affecting erythrocytes is the most common enzymopathy in humans. It requires caution with the intake of oxidizing substances (e.g., medications and foods) because of the threat of hemolysis. Less recognized is the threat of a deficiency in G6PD that alters neutrophil function, which can compromise the killing of microbes by the oxidative burst mechanism. This results from a secondary alteration in the NADPH oxidase pathway. Methicillin-resistant Staphylococcus aureus (MRSA) infection, which is usually observed after exposure in the hospital setting, is becoming increasingly common in a community setting. Here we show the risk of MRSA and G6PD deficiency and discuss the pitfalls of G6PD deficiency.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18450407</pmid><doi>10.1016/j.jemermed.2007.10.049</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of emergency medicine, 2009-10, Vol.37 (3), p.273-278 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | African Americans Anti-Bacterial Agents - therapeutic use Child, Preschool chronic granulomatous disease (CGD) Clindamycin - therapeutic use Emergency Emergency Service, Hospital glucose-6-phosphate dehydrogenase (G6PD) Glucosephosphate Dehydrogenase Deficiency - complications Glucosephosphate Dehydrogenase Deficiency - diagnosis Humans Infant Male methicillin-resistant Staphylococcus aureus (MRSA) Methicillin-Resistant Staphylococcus aureus - isolation & purification Recurrence Soft Tissue Infections - complications Soft Tissue Infections - drug therapy Soft Tissue Infections - ethnology Staphylococcal Infections - complications Staphylococcal Infections - drug therapy Staphylococcal Infections - ethnology Staphylococcus aureus |
| title | Treatment of MRSA Infections in an African-American Male with G6PD Deficiency |
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