Two-dimensional LC–MS/MS determination of antiretroviral drugs in rat serum and urine

A simple, rapid, reliable and highly sensitive on-line two-dimensional reversed-phase liquid chromatography–tandem mass spectrometric (2D-LC/MS/MS) method to determine antiretroviral drugs viz., abacavir (ABC), nevirapine (NVP) and indinavir (IDV) in rat serum and urine was developed and validated....

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2009-12, Vol.50 (5), p.994-999
Hauptverfasser:	Nageswara Rao, R., Shinde, Dhananjay D.
Format:	Artikel
Sprache:	eng
Schlagworte:	2D-LC/MS/MS Analysis Analytical, structural and metabolic biochemistry Animals Anti-Retroviral Agents - blood Anti-Retroviral Agents - urine Antiretrovirals Biological and medical sciences Calibration Chromatography, Liquid - methods Dideoxynucleosides - blood Dideoxynucleosides - urine Drug Monitoring - methods Equipment Design Fundamental and applied biological sciences. Psychology General pharmacology Medical sciences Models, Chemical Nevirapine - blood Nevirapine - urine Pharmacokinetics Pharmacology. Drug treatments Rat serum Rats Rats, Wistar Reproducibility of Results Restricted access medium (RAM) Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Time Factors
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