Enantioselective Chemoenzymatic Synthesis of trans-Aziridines

A straightforward, five-step procedure for the synthesis of enantiomerically pure 2,3-disubstituted trans-aziridines has been developed starting from commercially available aldehydes. Hydroxynitrile lyase-mediated cyanohydrin formation provided cyanohydrins in excellent enantioselectivities and good...

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Veröffentlicht in:	Journal of organic chemistry 2009-10, Vol.74 (19), p.7548-7551
Hauptverfasser:	Ritzen, Bas, van Oers, Matthijs C. M, van Delft, Floris L, Rutjes, Floris P. J. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde-Lyases - chemistry Aldehyde-Lyases - metabolism Aldehydes - chemistry Aziridines - chemical synthesis Aziridines - chemistry Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Methods. Procedures. Technologies Molecular Structure Organic chemistry Organometallic Compounds - chemistry Preparations and properties Stereoisomerism
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