Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives

A series of new S-adenosyl-L-homocysteine (AdoHcy) analogues with modifications to amino acid and nucleoside moieties was prepared via condensation of appropriate nucleoside precursors and suitably protected L-homocystine derivatives. The AdoHcy derivatives as well as the nucleoside precursors were...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-11, Vol.35 (24), p.4576-4583
Hauptverfasser:	Serafinowski, Pawel, Dorland, Erwin, Harrap, Kenneth R, Balzarini, Jan, De Clercq, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Cell Line HIV-1 - drug effects Humans Methyltransferases - antagonists & inhibitors Molecular Structure Rabbits S-Adenosylhomocysteine - analogs & derivatives Simplexvirus - drug effects Vaccinia virus - drug effects Vesicular stomatitis Indiana virus - drug effects
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