Preparation and characterization of β-tricalcium phosphate co-doped with monovalent and divalent antibacterial metal ions
Ag + and Zn 2+ or Cu 2+ ions were co-doped with β-tricalcium phosphate (AgZn–TCP and AgCu–TCP), and their substitution models, antimicrobial activities, mechanisms and cytotoxicities were investigated. The lattice constants ( a-axis and c-axis) of AgZn–TCP and AgCu–TCP decreased linearly with the am...
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| Veröffentlicht in: | Acta biomaterialia 2009-10, Vol.5 (8), p.3157-3164 |
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| creator | Matsumoto, N. Sato, K. Yoshida, K. Hashimoto, K. Toda, Y. |
| description | Ag
+ and Zn
2+ or Cu
2+ ions were co-doped with β-tricalcium phosphate (AgZn–TCP and AgCu–TCP), and their substitution models, antimicrobial activities, mechanisms and cytotoxicities were investigated. The lattice constants (
a-axis and
c-axis) of AgZn–TCP and AgCu–TCP decreased linearly with the amount of Zn
2+ or Cu
2+ ions up to 9.09
mol.%, which indicated that Ag
+ ions were doped at the Ca(4) site and a vacancy in the β-TCP structure, and Zn
2+ or Cu
2+ ions were doped at the Ca(5) site. Antibacterial activities of AgZn–TCP and AgCu–TCP on
Escherichia coli and
Staphylococcus aureus were higher than those of Ag
+ ions-doped β-TCP (Ag–TCP) and pure β-TCP. These antimicrobial activities suggested that an interaction occurred between bacteria and Ag
+, Zn
2+ and Cu
2+ ions eluted from AgZn–TCP and AgCu–TCP and between bacteria and the free radicals generated by antibacterial agents or in bacterial cells. AgZn–TCP and AgCu–TCP can be used over long periods of time with high antimicrobial activity, because the rate at which Ag
+ ions are released from AgZn–TCP and AgCu–TCP is slower than that at which Ag
+ ions are released from Ag–TCP. However, it is necessary to determine the suitable amounts of Ag
+, Zn
2+ and Cu
2+ ions in AgZn–TCP and AgCu–TCP by considering both their antimicrobial activities and cytotoxicities, because β-TCP doped with a large amount of these metal ions exhibits cytotoxicity. Furthermore, AgZn–TCP and AgCu–TCP are considered to be promising materials for use in various fields. |
| doi_str_mv | 10.1016/j.actbio.2009.04.010 |
| format | Article |
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+ and Zn
2+ or Cu
2+ ions were co-doped with β-tricalcium phosphate (AgZn–TCP and AgCu–TCP), and their substitution models, antimicrobial activities, mechanisms and cytotoxicities were investigated. The lattice constants (
a-axis and
c-axis) of AgZn–TCP and AgCu–TCP decreased linearly with the amount of Zn
2+ or Cu
2+ ions up to 9.09
mol.%, which indicated that Ag
+ ions were doped at the Ca(4) site and a vacancy in the β-TCP structure, and Zn
2+ or Cu
2+ ions were doped at the Ca(5) site. Antibacterial activities of AgZn–TCP and AgCu–TCP on
Escherichia coli and
Staphylococcus aureus were higher than those of Ag
+ ions-doped β-TCP (Ag–TCP) and pure β-TCP. These antimicrobial activities suggested that an interaction occurred between bacteria and Ag
+, Zn
2+ and Cu
2+ ions eluted from AgZn–TCP and AgCu–TCP and between bacteria and the free radicals generated by antibacterial agents or in bacterial cells. AgZn–TCP and AgCu–TCP can be used over long periods of time with high antimicrobial activity, because the rate at which Ag
+ ions are released from AgZn–TCP and AgCu–TCP is slower than that at which Ag
+ ions are released from Ag–TCP. However, it is necessary to determine the suitable amounts of Ag
+, Zn
2+ and Cu
2+ ions in AgZn–TCP and AgCu–TCP by considering both their antimicrobial activities and cytotoxicities, because β-TCP doped with a large amount of these metal ions exhibits cytotoxicity. Furthermore, AgZn–TCP and AgCu–TCP are considered to be promising materials for use in various fields.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2009.04.010</identifier><identifier>PMID: 19435618</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial metal ions ; Bacterial Physiological Phenomena - drug effects ; Bone Substitutes - chemistry ; Bone Substitutes - pharmacology ; Calcium Phosphates - chemistry ; Calcium Phosphates - pharmacology ; Cell Survival - drug effects ; Free radicals ; Ions ; Materials Testing ; Metals - chemistry ; Metals - pharmacology ; Solid solution ; Surface Properties ; β-Tricalcium phosphate</subject><ispartof>Acta biomaterialia, 2009-10, Vol.5 (8), p.3157-3164</ispartof><rights>2009 Acta Materialia Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-46fa27be66d64e2a597638b42c3e829f45a98c0f81cb118ad70dbf0035fc324b3</citedby><cites>FETCH-LOGICAL-c361t-46fa27be66d64e2a597638b42c3e829f45a98c0f81cb118ad70dbf0035fc324b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706109001627$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19435618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, N.</creatorcontrib><creatorcontrib>Sato, K.</creatorcontrib><creatorcontrib>Yoshida, K.</creatorcontrib><creatorcontrib>Hashimoto, K.</creatorcontrib><creatorcontrib>Toda, Y.</creatorcontrib><title>Preparation and characterization of β-tricalcium phosphate co-doped with monovalent and divalent antibacterial metal ions</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Ag
+ and Zn
2+ or Cu
2+ ions were co-doped with β-tricalcium phosphate (AgZn–TCP and AgCu–TCP), and their substitution models, antimicrobial activities, mechanisms and cytotoxicities were investigated. The lattice constants (
a-axis and
c-axis) of AgZn–TCP and AgCu–TCP decreased linearly with the amount of Zn
2+ or Cu
2+ ions up to 9.09
mol.%, which indicated that Ag
+ ions were doped at the Ca(4) site and a vacancy in the β-TCP structure, and Zn
2+ or Cu
2+ ions were doped at the Ca(5) site. Antibacterial activities of AgZn–TCP and AgCu–TCP on
Escherichia coli and
Staphylococcus aureus were higher than those of Ag
+ ions-doped β-TCP (Ag–TCP) and pure β-TCP. These antimicrobial activities suggested that an interaction occurred between bacteria and Ag
+, Zn
2+ and Cu
2+ ions eluted from AgZn–TCP and AgCu–TCP and between bacteria and the free radicals generated by antibacterial agents or in bacterial cells. AgZn–TCP and AgCu–TCP can be used over long periods of time with high antimicrobial activity, because the rate at which Ag
+ ions are released from AgZn–TCP and AgCu–TCP is slower than that at which Ag
+ ions are released from Ag–TCP. However, it is necessary to determine the suitable amounts of Ag
+, Zn
2+ and Cu
2+ ions in AgZn–TCP and AgCu–TCP by considering both their antimicrobial activities and cytotoxicities, because β-TCP doped with a large amount of these metal ions exhibits cytotoxicity. Furthermore, AgZn–TCP and AgCu–TCP are considered to be promising materials for use in various fields.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial metal ions</subject><subject>Bacterial Physiological Phenomena - drug effects</subject><subject>Bone Substitutes - chemistry</subject><subject>Bone Substitutes - pharmacology</subject><subject>Calcium Phosphates - chemistry</subject><subject>Calcium Phosphates - pharmacology</subject><subject>Cell Survival - drug effects</subject><subject>Free radicals</subject><subject>Ions</subject><subject>Materials Testing</subject><subject>Metals - chemistry</subject><subject>Metals - pharmacology</subject><subject>Solid solution</subject><subject>Surface Properties</subject><subject>β-Tricalcium phosphate</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxTAQhoMo3t9ApDtXrUmTpulGEPEGgi50HdJkysmhbWqSo-hj-SA-k9EedOdmbvzzD_MhdERwQTDhp8tC6dhaV5QYNwVmBSZ4A-0SUYu8rrjYTHXNyrzGnOygvRCWGFNBSrGNdkjDaMWJ2EXvDx4m5VW0bszUaDK9SJ2O4O37PHRd9vmRR2-16rVdDdm0cGFaqAiZdrlxE5js1cZFNrjRvagexvhjZOxvE207W6o-GyCmmIzDAdrqVB_gcJ330dPV5ePFTX53f317cX6Xa8pJzBnvVFm3wLnhDEpVNTWnomWlpiDKpmOVaoTGnSC6JUQoU2PTdunXqtO0ZC3dRyez7-Td8wpClIMNGvpejeBWQdaU4YpTwpOSzUrtXQgeOjl5Oyj_JgmW39DlUs7Q5Td0iZlM0NPa8frAqh3A_C2tKSfB2SyA9OaLBS-DtjBqMNaDjtI4-_-FL1ZcmEA</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Matsumoto, N.</creator><creator>Sato, K.</creator><creator>Yoshida, K.</creator><creator>Hashimoto, K.</creator><creator>Toda, Y.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Preparation and characterization of β-tricalcium phosphate co-doped with monovalent and divalent antibacterial metal ions</title><author>Matsumoto, N. ; Sato, K. ; Yoshida, K. ; Hashimoto, K. ; Toda, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-46fa27be66d64e2a597638b42c3e829f45a98c0f81cb118ad70dbf0035fc324b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial metal ions</topic><topic>Bacterial Physiological Phenomena - drug effects</topic><topic>Bone Substitutes - chemistry</topic><topic>Bone Substitutes - pharmacology</topic><topic>Calcium Phosphates - chemistry</topic><topic>Calcium Phosphates - pharmacology</topic><topic>Cell Survival - drug effects</topic><topic>Free radicals</topic><topic>Ions</topic><topic>Materials Testing</topic><topic>Metals - chemistry</topic><topic>Metals - pharmacology</topic><topic>Solid solution</topic><topic>Surface Properties</topic><topic>β-Tricalcium phosphate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, N.</creatorcontrib><creatorcontrib>Sato, K.</creatorcontrib><creatorcontrib>Yoshida, K.</creatorcontrib><creatorcontrib>Hashimoto, K.</creatorcontrib><creatorcontrib>Toda, Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, N.</au><au>Sato, K.</au><au>Yoshida, K.</au><au>Hashimoto, K.</au><au>Toda, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and characterization of β-tricalcium phosphate co-doped with monovalent and divalent antibacterial metal ions</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>5</volume><issue>8</issue><spage>3157</spage><epage>3164</epage><pages>3157-3164</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>Ag
+ and Zn
2+ or Cu
2+ ions were co-doped with β-tricalcium phosphate (AgZn–TCP and AgCu–TCP), and their substitution models, antimicrobial activities, mechanisms and cytotoxicities were investigated. The lattice constants (
a-axis and
c-axis) of AgZn–TCP and AgCu–TCP decreased linearly with the amount of Zn
2+ or Cu
2+ ions up to 9.09
mol.%, which indicated that Ag
+ ions were doped at the Ca(4) site and a vacancy in the β-TCP structure, and Zn
2+ or Cu
2+ ions were doped at the Ca(5) site. Antibacterial activities of AgZn–TCP and AgCu–TCP on
Escherichia coli and
Staphylococcus aureus were higher than those of Ag
+ ions-doped β-TCP (Ag–TCP) and pure β-TCP. These antimicrobial activities suggested that an interaction occurred between bacteria and Ag
+, Zn
2+ and Cu
2+ ions eluted from AgZn–TCP and AgCu–TCP and between bacteria and the free radicals generated by antibacterial agents or in bacterial cells. AgZn–TCP and AgCu–TCP can be used over long periods of time with high antimicrobial activity, because the rate at which Ag
+ ions are released from AgZn–TCP and AgCu–TCP is slower than that at which Ag
+ ions are released from Ag–TCP. However, it is necessary to determine the suitable amounts of Ag
+, Zn
2+ and Cu
2+ ions in AgZn–TCP and AgCu–TCP by considering both their antimicrobial activities and cytotoxicities, because β-TCP doped with a large amount of these metal ions exhibits cytotoxicity. Furthermore, AgZn–TCP and AgCu–TCP are considered to be promising materials for use in various fields.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19435618</pmid><doi>10.1016/j.actbio.2009.04.010</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Acta biomaterialia, 2009-10, Vol.5 (8), p.3157-3164 |
| issn | 1742-7061 1878-7568 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial metal ions Bacterial Physiological Phenomena - drug effects Bone Substitutes - chemistry Bone Substitutes - pharmacology Calcium Phosphates - chemistry Calcium Phosphates - pharmacology Cell Survival - drug effects Free radicals Ions Materials Testing Metals - chemistry Metals - pharmacology Solid solution Surface Properties β-Tricalcium phosphate |
| title | Preparation and characterization of β-tricalcium phosphate co-doped with monovalent and divalent antibacterial metal ions |
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