Evidence for potential functionality of nuclearly-encoded humanin isoforms

Humanin (HN) is a recently identified neuroprotective and antiapoptotic peptide derived from a portion of the mitochondrial MT-RNR2 gene. We provide bioinformatic and expression data suggesting the existence of 13 MT-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2009-10, Vol.94 (4), p.247-256
Hauptverfasser:	Bodzioch, Marek, Lapicka-Bodzioch, Katarzyna, Zapala, Barbara, Kamysz, Wojciech, Kiec-Wilk, Beata, Dembinska-Kiec, Aldona
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Ageing, cell death Amino Acid Motifs Amino Acid Sequence Amino Acid Substitution Animals Apoptosis Apoptosis - genetics beta Carotene - pharmacology Beta-carotene Biological and medical sciences Cell Nucleus - genetics Cell physiology Cells, Cultured Chromosomes, Human Chromosomes, Mammalian Computational Biology - methods Consensus Sequence DNA, Complementary Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Genes. Genome Genetic variation Genetics of eukaryotes. Biological and molecular evolution Genome, Human Heterozygote Homozygote Humanin Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Isoleucine - metabolism Mitochondria - metabolism Mitochondrial function Molecular and cellular biology Molecular genetics Molecular Sequence Data Neuroprotective Agents - pharmacology Open Reading Frames - genetics Pan troglodytes Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Mapping Phylogeny Protein Isoforms - genetics Protein Isoforms - metabolism Rhodamines - metabolism Sequence Homology, Amino Acid Staurosporine - pharmacology Time Factors Umbilical Veins - cytology
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